Application of first order rate kinetics to explain changes in bloom toxicity-the importance of understanding cell toxin quotas

ORR Philip T.; WILLIS Anusuya; BURFORD Michele A.

doi:10.1007/s00343-019-7188-z

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Application of first order rate kinetics to explain changes in bloom toxicity-the importance of understanding cell toxin quotas

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- Application of first order rate kinetics to explain changes in bloom toxicity-the importance of understanding cell toxin quotas
- Application of first order rate kinetics to explain changes in bloom toxicity-the importance of understanding cell toxin quotas
- 海洋湖沼学报（英文） 2018年36卷第4期页码：1063-1074
- Affiliations：
  
  Australian Rivers Institute, Griffith University, 170 Kessels Rd, Nathan, Qld 4111, Australia
- Author bio：
  
  Philip T. ORR, p.orr@griffith.edu.au
- Funds：
  
  Supported by the Griffith University
- DOI：10.1007/s00343-019-7188-z
  中图分类号：
- 收稿：2017-06-28，
  
  录用：2017-7-24，
  
  网络首发：2017-11-08，
  
  纸质出版：2018-07
- Accepted：
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Application of first order rate kinetics to explain changes in bloom toxicity-the importance of understanding cell toxin quotas[J]. 海洋湖沼学报（英文）, 2018,36(4):1063-1074.

ORR Philip T., WILLIS Anusuya, BURFORD Michele A.. Application of first order rate kinetics to explain changes in bloom toxicity-the importance of understanding cell toxin quotas[J]. Chinese Journal of Oceanology and Limnology, 2018, 36(4): 1063-1074.
Application of first order rate kinetics to explain changes in bloom toxicity-the importance of understanding cell toxin quotas[J]. 海洋湖沼学报（英文）, 2018,36(4):1063-1074. DOI： 10.1007/s00343-019-7188-z.

ORR Philip T., WILLIS Anusuya, BURFORD Michele A.. Application of first order rate kinetics to explain changes in bloom toxicity-the importance of understanding cell toxin quotas[J]. Chinese Journal of Oceanology and Limnology, 2018, 36(4): 1063-1074. DOI： 10.1007/s00343-019-7188-z.

摘要

Abstract

Cyanobacteria are oxygenic photosynthetic Gram-negative bacteria that can form potentially toxic blooms in eutrophic and slow flowing aquatic ecosystems. Bloom toxicity varies spatially and temporally

but understanding the mechanisms that drive these changes remains largely a mystery. Changes in bloom toxicity may result from changes in intracellular toxin pool sizes of cyanotoxins with differing molecular toxicities

and/or from changes in the cell concentrations of toxic and non-toxic cyanobacterial species or strains within bloom populations. We show here how first-order rate kinetics at the cellular level can be used to explain how environmental conditions drive changes in bloom toxicity at the ecological level. First order rate constants can be calculated for changes in cell concentration (

:specific cell division rate) or the volumetric biomass concentration (

:specific growth rate) between short time intervals throughout the cell cycle. Similar first order rate constants can be calculated for changes in nett volumetric cyanotoxin concentration (

tox

:specific cyanotoxin production rate) over similar time intervals. How

(or

) covaries with

tox

over the cell cycle shows conclusively when cyanotoxins are being produced and metabolised

and how the toxicity of cells change in response to environment stressors. When

tox

cyanotoxin cell quotasincrease and individual cells become more toxic because the nett cyanotoxin production rate is higher than the cell division rate. When

tox

cell cyanotoxin quotas remains fixed because the nett cyanotoxin production rate matches the cell division rate. When

tox

the cyanotoxin cell quota decreases because either the nett cyanotoxin production rate is lower than the cell division rate

or metabolic breakdown and/or secretion of cyanotoxins is occurring. These fundamental equations describe cyanotoxin metabolism dynamics at the cellular level and provide the necessary physiological background to understand how environmental stressors drive changes in bloom toxicity.

关键词

Keywords

references

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