Sulfated polysaccharides with antioxidant and anticoagulant activity from the sea cucumber Holothuria fuscogliva

Rongfeng Li; Huahua Yu; Yang Yue; Song Liu; Rong’e Xing; Xiaolin Chen; Pengcheng Li

doi:10.1007/s00343-017-5339-7

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Sulfated polysaccharides with antioxidant and anticoagulant activity from the sea cucumber Holothuria fuscogliva

OriginalPaper | Updated：2023-05-16

- Sulfated polysaccharides with antioxidant and anticoagulant activity from the sea cucumber Holothuria fuscogliva
- Sulfated polysaccharides with antioxidant and anticoagulant activity from the sea cucumber Holothuria fuscogliva
- 海洋湖沼学报（英文） 2017年35卷第4期页码：763-769
- Affiliations：
  
  1. Key Laboratory of Experimental Marine Biology Institute of Oceanology Chinese Academy of Sciences
  2. University of Chinese Academy of Sciences
- Author bio：
- Funds：
  
  Supported by the Science and Technology Service Network Program of Chinese Academy of Sciences (No. KFJ-EW-STS-060), the National Special Research Fund for Non-Profit Marine Sector (No. 201405038-2), and the Scientific and Technological Innovation Project Financially Supported by Qingdao National Laboratory for Marine Science and Technology (No.2015ASKJ02)
- DOI：10.1007/s00343-017-5339-7
  中图分类号：
- 网络首发：2016-08-12，
  
  纸质出版：2017
- Accepted：
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Sulfated polysaccharides with antioxidant and anticoagulant activity from the sea cucumber Holothuria fuscogliva[J]. 海洋湖沼学报（英文）, 2017,35(4):763-769.

Li, R., Yu, H., Yue, Y. et al. Sulfated polysaccharides with antioxidant and anticoagulant activity from the sea cucumber Holothuria fuscogliva, ., Chin. J. Ocean. Limnol. 35, 763–769 (2017). https://doi.org/10.1007/s00343-017-5339-7
Sulfated polysaccharides with antioxidant and anticoagulant activity from the sea cucumber Holothuria fuscogliva[J]. 海洋湖沼学报（英文）, 2017,35(4):763-769. DOI： 10.1007/s00343-017-5339-7.

Li, R., Yu, H., Yue, Y. et al. Sulfated polysaccharides with antioxidant and anticoagulant activity from the sea cucumber Holothuria fuscogliva, ., Chin. J. Ocean. Limnol. 35, 763–769 (2017). https://doi.org/10.1007/s00343-017-5339-7 DOI：

摘要

Abstract

Sea cucumber is a traditional nutritional food and medicinal resource with many bioactive components in China. Holothuria fuscogliva is a big sea cucumber with a rich of bioactive polysaccharides. To investigate the bioactivities of the polysaccharides from sea cucumber H. fuscogliva

we prepared the sulfated polysaccharides (HfP) from sea cucumber H. fuscogliva using a protease hydrolysis method. Antioxidant activities of HfP were investigated

including hydroxyl radical scavenging activity and superoxide radical scavenging activity. And

the anticoagulant activities of HfP were studied

including the activated partial thromboplastin time (APTT)

prothrombin time (PT) and thrombin time (TT). The average molecular weight was 1 867.1 Da

with a sulfate content of 20.7%. In addition

the molar ratio of monosaccharide composition of HfP was Man: Rha: Glc A: Glc: Gal: Xyl: Fuc=0.083 6: 0.437: 0.134: 0:1.182: 0.748: 1. It had a strong antioxidant activity

the hydroxyl and superoxide radical scavenging activity EC50 of HfP was 3.74 and 0.037 mg/mL

respectively. It also showed a good anticoagulant activity in our study. The APTT of HfP was much higher than that of heparin sodium

and the PT and TT of HfP was close to that of heparin sodium at a low concentration. Therefore

HfP shows a good antioxidant and anticoagulant activity and it may become a potential candidate of the natural antioxidant and anticoagulant and will have a good application future in health product or medicine industry.

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references

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