Phenylquinolinones with antitumor activity from the Indian Ocean-derived fungus Aspergillus versicolor Y31-2

Peihai Li; Yaqin Fan; Hao Chen; Yaxi Chao; Ning Du; Junhui Chen

doi:10.1007/s00343-016-5097-y

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Phenylquinolinones with antitumor activity from the Indian Ocean-derived fungus Aspergillus versicolor Y31-2

OriginalPaper | Updated：2023-05-16

- Phenylquinolinones with antitumor activity from the Indian Ocean-derived fungus Aspergillus versicolor Y31-2
- Phenylquinolinones with antitumor activity from the Indian Ocean-derived fungus Aspergillus versicolor Y31-2
- 海洋湖沼学报（英文） 2016年34卷第5期页码：1072-1075
- Affiliations：
  
  Key Lab of Marine Bioactive Substances First Institute of Oceanography State Oceanic Administration (SOA)
- Author bio：
- Funds：
  
  Supported by the National Basic Research Program of China (973 Program) (No. 2015CB755906), the National High Technology Research and Development Program of China (863 Program) (No. 2013AA092901-2), the China Ocean Mineral Resources Research and Development Association (No. DY125-15-T-07), the Public Welfare Project of SOA (No. 201205027), and the Basic Scientific Fund for National Public Research Institutes of China (No. GY0213G12);LI Peihai and FAN Yaqin contributed equally to this work.
- DOI：10.1007/s00343-016-5097-y
  中图分类号：
- 网络首发：2016-02-05，
  
  纸质出版：2016
- Accepted：
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Phenylquinolinones with antitumor activity from the Indian Ocean-derived fungus Aspergillus versicolor Y31-2[J]. 海洋湖沼学报（英文）, 2016,34(5):1072-1075.

Li, P., Fan, Y., Chen, H. et al. Phenylquinolinones with antitumor activity from the Indian Ocean-derived fungus Aspergillus versicolor Y31-2., Chin. J. Ocean. Limnol. 34, 1072–1075 (2016). https://doi.org/10.1007/s00343-016-5097-y
Phenylquinolinones with antitumor activity from the Indian Ocean-derived fungus Aspergillus versicolor Y31-2[J]. 海洋湖沼学报（英文）, 2016,34(5):1072-1075. DOI： 10.1007/s00343-016-5097-y.

Li, P., Fan, Y., Chen, H. et al. Phenylquinolinones with antitumor activity from the Indian Ocean-derived fungus Aspergillus versicolor Y31-2., Chin. J. Ocean. Limnol. 34, 1072–1075 (2016). https://doi.org/10.1007/s00343-016-5097-y DOI：

摘要

Abstract

Two phenylquinolinones

including one new compound (1) and a previously isolated compound (2)

were isolated from the ethyl acetate extracts of the fungus Aspergillus versicolor Y31-2

which was obtained from seawater samples collected from the Indian Ocean. The structures of these compounds were established by spectroscopic analyses. 4-(3-Hydroxyphenyl)-3-methoxyquinolin-2(1H)-one (1) exhibited moderate cytotoxicity against MCF-7 (human breast carcinoma cell line) and SMMC-7721 (human liver cancer cell line) cells with IC50 values of 16.6 and 18.2 μmol/L

respectively. To the best of our knowledge

this study represents the first reported account of the isolation of compounds 1 and 2 as the secondary metabolites of the seawater derived fungus Aspergillus versicolor from the Indian Ocean.

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references

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