Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice

Dong Xia; Bing Liu; Xiying Luan; Junyan Sun; Nana Liu; Song Qin; Zhenning Du

doi:10.1007/s00343-015-4312-6

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Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice

OriginalPaper | Updated：2023-05-16

- Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice
- Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice
- 海洋湖沼学报（英文） 2016年34卷第2期页码：399-404
- Affiliations：
  
  1. School of Pharmacy Yantai University
  2. Key Laboratory of Coastal Biology and Bioresource Utilization Yantai institute of Coastal Zone Research Chinese Academy of Sciences
  3. School of Basic Medical Binzhou Medical University
- Author bio：
- Funds：
  
  Supported by the National Special Research Fund for Non-Profit Marine Sector (No. 201205027) and the Taishan Scholar Program of Shandong Province
- DOI：10.1007/s00343-015-4312-6
  中图分类号：
- 网络首发：2015-08-01，
  
  纸质出版：2016
- Accepted：
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Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice[J]. 海洋湖沼学报（英文）, 2016,34(2):399-404.

Xia, D., Liu, B., Luan, X. et al. Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice., Chin. J. Ocean. Limnol. 34, 399–404 (2016). https://doi.org/10.1007/s00343-015-4312-6
Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice[J]. 海洋湖沼学报（英文）, 2016,34(2):399-404. DOI： 10.1007/s00343-015-4312-6.

Xia, D., Liu, B., Luan, X. et al. Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice., Chin. J. Ocean. Limnol. 34, 399–404 (2016). https://doi.org/10.1007/s00343-015-4312-6 DOI：

摘要

Abstract

Excessive alcohol consumption leads to liver disease. Extensive evidence suggests that C-phycocyanin (C-PC)

a chromophore phycocyanobilin derived from Spirulina platensis

exerts protective effects against chemical-induced organ damage. In this study

we investigated whether C-PC could protect against ethanol-induced acute liver injury. Serum alanine aminotransferase (ALT)

aspartate aminotransferase (AST)

triglyceride (TG)

total cholesterol (CHOL)

low-density lipoprotein (LDL)

liver homogenate malondialdehyde (MDA)

superoxide dismutase (SOD) content were measured

and pathological examination of liver sections were examined. C-PC showed obvious inhibitory effects on serum ALT

AST

CHOL

LDL and MDA

and SOD content significantly increased in the liver. The structure of hepatic lobules was clear

liver sinus returned to normal

and liver cell cords were arranged in neat rows. Cloudiness

swelling

inflammatory cell infiltration and spotty necrosis of liver cells were significantly reduced. Therefore

C-PC can significantly protect against ethanol-induced acute liver injury.

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references

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