Antiaging activity of low molecular weight peptide from Paphia undulate

Xin Chen; Bingna Cai; Hua Chen; Jianyu Pan; Deke Chen; Huili Sun

doi:10.1007/s00343-013-2222-z

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Antiaging activity of low molecular weight peptide from Paphia undulate

OriginalPaper | Updated：2023-05-16

- Antiaging activity of low molecular weight peptide from Paphia undulate
- Antiaging activity of low molecular weight peptide from Paphia undulate
- 海洋湖沼学报（英文） 2013年31卷第3期页码：570-580
- Affiliations：
  
  1. Science School of Foshan University
  2. Key Laboratory of Marine Bio-resources Sustainable Utilization South China Sea Institute of Oceanology Chinese Academy of Sciences
  3. Graduate University of Chinese Academy of Sciences
- Author bio：
- Funds：
  
  Supported by the Knowledge Innovation Program of Chinese Academy of Sciences (No. KZCX2-EW-Q214), the Comprehensive Strategic Cooperation Programs between Guangdong Province and Chinese Academy of Sciences (Nos. 2011A090100008, 2009B091300018, 2010B090300027), and the Marine Fisheries Technology Promotion Special Program of Guangdong Province, China (No. A2009009-035(a))
- DOI：10.1007/s00343-013-2222-z
  中图分类号：
- 网络首发：2013-05-08，
  
  纸质出版：2013
- Accepted：
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Antiaging activity of low molecular weight peptide from Paphia undulate[J]. 海洋湖沼学报（英文）, 2013,31(3):570-580.

Chen, X., Cai, B., Chen, H. et al. Antiaging activity of low molecular weight peptide from Paphia undulate, ., Chin. J. Ocean. Limnol. 31, 570–580 (2013). https://doi.org/10.1007/s00343-013-2222-z
Antiaging activity of low molecular weight peptide from Paphia undulate[J]. 海洋湖沼学报（英文）, 2013,31(3):570-580. DOI： 10.1007/s00343-013-2222-z.

Chen, X., Cai, B., Chen, H. et al. Antiaging activity of low molecular weight peptide from Paphia undulate, ., Chin. J. Ocean. Limnol. 31, 570–580 (2013). https://doi.org/10.1007/s00343-013-2222-z DOI：

摘要

Abstract

Low molecular weight peptide (LMWP) was prepared from clam Paphia undulate and its antiaging effect on D-galactose-induced acute aging in rats

aged Kunming mice

ultraviolet-exposed rats

and thermally injured rats was investigated. P. undulate flesh was homogenized and digested using papain under optimal conditions

then subjected to Sephadex G-25 chromatography to isolate the LMWP. Administration of LMWP significantly reversed D-galactose-induced oxidative stress by increasing the activities of glutathione peroxidase (GPx) and catalase (CAT)

and by decreasing the level of malondialdehyde (MDA). This process was accompanied by increased collagen synthesis. The LMWP prevented photoaging and promoted dermis recovery and remission of elastic fiber hyperplasia. Furthermore

treatment with the LMWP helped to regenerate elastic fibers and the collagen network

increased superoxide dismutase (SOD) in the serum and significantly decreased MDA. Thermal scald-induced inflammation and edema were also relieved by the LWMP

while wound healing in skin was promoted. These results suggest that the LMWP from P. undulate could serve as a new antiaging substance in cosmetics.

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