Optimized water vapor permeability of sodium alginate films using response surface methodology

Qing Zhang; Jiachao Xu; Xin Gao; Xiaoting Fu

doi:10.1007/s00343-013-2125-z

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Optimized water vapor permeability of sodium alginate films using response surface methodology

OriginalPaper | Updated：2023-05-16

- Optimized water vapor permeability of sodium alginate films using response surface methodology
- Optimized water vapor permeability of sodium alginate films using response surface methodology
- 海洋湖沼学报（英文） 2013年31卷第6期页码：1196-1203
- Affiliations：
  
  College of Food Science and Engineering Ocean University of China
- Author bio：
- Funds：
  
  Supported by the Program for Transformation of Scientific and Technological Achievements of Jiangsu Province, China (No. BA2009088)
- DOI：10.1007/s00343-013-2125-z
  中图分类号：
- 网络首发：2013-07-27，
  
  纸质出版：2013
- Accepted：
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Optimized water vapor permeability of sodium alginate films using response surface methodology[J]. 海洋湖沼学报（英文）, 2013,31(6):1196-1203.

Zhang, Q., Xu, J., Gao, X. et al. Optimized water vapor permeability of sodium alginate films using response surface methodology., Chin. J. Ocean. Limnol. 31, 1196–1203 (2013). https://doi.org/10.1007/s00343-013-2125-z
Optimized water vapor permeability of sodium alginate films using response surface methodology[J]. 海洋湖沼学报（英文）, 2013,31(6):1196-1203. DOI： 10.1007/s00343-013-2125-z.

Zhang, Q., Xu, J., Gao, X. et al. Optimized water vapor permeability of sodium alginate films using response surface methodology., Chin. J. Ocean. Limnol. 31, 1196–1203 (2013). https://doi.org/10.1007/s00343-013-2125-z DOI：

摘要

Abstract

The water vapor permeability (WVP) of films is important when developing pharmaceutical applications. Films are frequently used as coatings

and as such directly influence the quality of the medicine. The optimization of processing conditions for sodium alginate films was investigated using response surface methodology. Single-factor tests and Box-Behnken experimental design were employed. WVP was selected as the response variable

and the operating parameters for the single-factor tests were sodium alginate concentration

carboxymethyl cellulose (CMC) concentration and CaCl2 solution immersion time. The coefficient of determination (R 2) was 0.97

indicating statistical significance. A minimal WVP of 0.389 8 g·mm/(m2·h·kPa) was achieved under the optimum conditions. These were found to be a sodium alginate concentration

CMC concentration and CaCl2 solution immersion time at 8.04%

0.13%

and 12 min

respectively. This provides a reference for potential applications in manufacturing film-coated hard capsule shells.

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references

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