Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118

Zhuo Shang; Xiaoming Li; Li Meng; Chunshun Li; Shushan Gao; Caiguo Huang; Bingui Wang

doi:10.1007/s00343-012-1075-1

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Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118

OriginalPaper | Updated：2023-05-16

- Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118
- Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118
- 海洋湖沼学报（英文） 2012年30卷第2期页码：305-314
- Affiliations：
  
  1. Key Laboratory of Experimental Marine Biology Institute of Oceanology Chinese Academy of Sciences
  2. Graduate University of Chinese Academy of Sciences
  3. Department of Biochemistry and Molecular Biology Second Military Medical University
- Author bio：
- Funds：
  
  Supported by the Ministry of Science and Technology (No. 2010CB833802), the Knowledge Innovation Program of Chinese Academy of Sciences (No. KSCX2-EW-G-12B), and the National Natural Science Foundation of China (No. 30910103914)
- DOI：10.1007/s00343-012-1075-1
  中图分类号：
- 网络首发：2012-03-01，
  
  纸质出版：2012
- Accepted：
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Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118[J]. 海洋湖沼学报（英文）, 2012,30(2):305-314.

Shang, Z., Li, X., Meng, L. et al. Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118., Chin. J. Ocean. Limnol. 30, 305–314 (2012). https://doi.org/10.1007/s00343-012-1075-1
Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118[J]. 海洋湖沼学报（英文）, 2012,30(2):305-314. DOI： 10.1007/s00343-012-1075-1.

Shang, Z., Li, X., Meng, L. et al. Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118., Chin. J. Ocean. Limnol. 30, 305–314 (2012). https://doi.org/10.1007/s00343-012-1075-1 DOI：

摘要

Abstract

Bioassay-guided fractionation of the crude extract from Penicillium commune SD-118

a fungus obtained from a deep-sea sediment sample

resulted in the isolation of a known antibacterial compound

xanthocillin X (1)

and 14 other known compounds comprising three steroids (2–4)

two ceramides (5 and 6)

six aromatic compounds (7–12)

and three alkaloids (13–15). Xanthocillin X (1) was isolated for the first time from a marine fungus. In the bioassay

xanthocillin X (1) displayed remarkable antimicrobial activity against Staphylococcus aureus and Escherichia coli

and significant cytotoxicity against MCF-7

HepG2

H460

Hela

Du145

and MDA-MB-231 cell lines. Meleagrin (15) exhibited cytotoxicity against HepG2

Hela

Du145

and MDA-MB-231 cell lines. This is the first report of the cytotoxicity of xanthocillin X (1).

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references

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