Differences in MITF gene expression and histology between albino and normal sea cucumbers (Apostichopus japonicus Selenka)

Heling Zhao; Hongsheng Yang; Huan Zhao; Shilin Liu; Tianming Wang

doi:10.1007/s00343-012-1043-9

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Differences in MITF gene expression and histology between albino and normal sea cucumbers (Apostichopus japonicus Selenka)

OriginalPaper | Updated：2023-05-16

- Differences in MITF gene expression and histology between albino and normal sea cucumbers (Apostichopus japonicus Selenka)
- Differences in MITF gene expression and histology between albino and normal sea cucumbers (Apostichopus japonicus Selenka)
- 海洋湖沼学报（英文） 2012年30卷第1期页码：80-91
- Affiliations：
  
  1. Graduate University of Chinese Academy of Sciences
  2. Key Laboratory of Marine Ecology and Environmental Sciences Institute of Oceanology Chinese Academy of Sciences
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 40976089), the National Marine Public Welfare Research Project (No. 200805069), the National Science and Technology Support Program of China (No. 2011BAD13B02), and the Breeding Project of Shandong Province (China)
- DOI：10.1007/s00343-012-1043-9
  中图分类号：
- 网络首发：2012-11-15，
  
  纸质出版：2012
- Accepted：
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Differences in MITF gene expression and histology between albino and normal sea cucumbers (Apostichopus japonicus Selenka)[J]. 海洋湖沼学报（英文）, 2012,30(1):80-91.

Zhao, H., Yang, H., Zhao, H. et al. Differences in MITF gene expression and histology between albino and normal sea cucumbers (Apostichopus japonicus Selenka)., Chin. J. Ocean. Limnol. 30, 80–91 (2012). https://doi.org/10.1007/s00343-012-1043-9
Differences in MITF gene expression and histology between albino and normal sea cucumbers (Apostichopus japonicus Selenka)[J]. 海洋湖沼学报（英文）, 2012,30(1):80-91. DOI： 10.1007/s00343-012-1043-9.

Zhao, H., Yang, H., Zhao, H. et al. Differences in MITF gene expression and histology between albino and normal sea cucumbers (Apostichopus japonicus Selenka)., Chin. J. Ocean. Limnol. 30, 80–91 (2012). https://doi.org/10.1007/s00343-012-1043-9 DOI：

摘要

Abstract

Albino Apostichopus japonicus occur both in the wild and in captivity. The offspring of albino A. japonicus also suffer from albinism. The formation of melanin in the melanocytes is dependant on microphthalmia-associated transcription factor (MITF). To investigate the role of MITF in controlling albinism

we cloned the full-length MITF cDNA from A. japonicus and compared MITF mRNA expression in albino and normal A. japonicus. In addition

we used light and electron microscopy to compare histological samples of normal and albino A. japonicus. The body wall of albino adults was characterized by significantly lower levels of MITF expression and lower numbers of epidermal melanocytes

which also contained less melanin. In albino juvenile offspring

MITF expression levels were significantly lower 32 d after fertilization and there were fewer

and less developed

epidermal melanocytes. Thus

we conclude that albino A. japonicus have fewer melanocytes and a reduced ability to synthesize melanin

likely because of lower expression of MITF.

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references

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