Evaluation of mouse bioassay results in an inter-laboratory comparison for paralytic shellfish poisoning toxins

Jijuan Cao; Jiang Zheng; Bing Yu; Qiuyan Wang; Junyi Xu; Aifeng Li

doi:10.1007/s00343-011-0521-9

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Evaluation of mouse bioassay results in an inter-laboratory comparison for paralytic shellfish poisoning toxins

OriginalPaper | Updated：2023-05-16

- Evaluation of mouse bioassay results in an inter-laboratory comparison for paralytic shellfish poisoning toxins
- Evaluation of mouse bioassay results in an inter-laboratory comparison for paralytic shellfish poisoning toxins
- 海洋湖沼学报（英文） 2011年29卷第4期页码：912-916
- Affiliations：
  
  1. Liaoning Entry-Exit Inspection and Quarantine Bureau
  2. Key Laboratory of Marine Environment and Ecology Ocean University of China Ministry of Education
- Author bio：
- Funds：
  
  Supported by a thesis research project of General Administration of Quality Supervision, Inspection and Quarantine of China (No. 2010IK168)
- DOI：10.1007/s00343-011-0521-9
  中图分类号：
- 网络首发：2011-07-10，
  
  纸质出版：2011
- Accepted：
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Evaluation of mouse bioassay results in an inter-laboratory comparison for paralytic shellfish poisoning toxins[J]. 海洋湖沼学报（英文）, 2011,29(4):912-916.

Cao, J., Zheng, J., Yu, B. et al. Evaluation of mouse bioassay results in an inter-laboratory comparison for paralytic shellfish poisoning toxins., Chin. J. Ocean. Limnol. 29, 912–916 (2011). https://doi.org/10.1007/s00343-011-0521-9
Evaluation of mouse bioassay results in an inter-laboratory comparison for paralytic shellfish poisoning toxins[J]. 海洋湖沼学报（英文）, 2011,29(4):912-916. DOI： 10.1007/s00343-011-0521-9.

Cao, J., Zheng, J., Yu, B. et al. Evaluation of mouse bioassay results in an inter-laboratory comparison for paralytic shellfish poisoning toxins., Chin. J. Ocean. Limnol. 29, 912–916 (2011). https://doi.org/10.1007/s00343-011-0521-9 DOI：

摘要

Abstract

An inter-laboratory comparison of the AOAC mouse bioassay for paralytic shellfish poisoning (PSP) toxicity in shellfish was carried out among 25 Chinese laboratories to examine the overall performance for PSP testing in China

and to analyze the main factors affecting the performance of this method. The toxic scallop Patinopecten yessoensis collected from coast of Bohai Sea

China

was used as a test sample in the comparison study. The results were reported and evaluated using robust statistical methods. The z scores showed that 80%

and 12% of laboratories reported satisfactory results

unsatisfactory results

and questionable results

respectively. This evaluation demonstrates that the PSP mouse bioassay is an appropriate method for screening and testing PSP toxicity in shellfish. However

it was found that the experience and skill of technicians

as well as the body weight and health status of mice being used significantly affected the accuracy of the method.

关键词

Keywords

references

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