The role of phosphatidylinositol signaling pathway in regulating serotonin-induced oocyte maturation in Mercenaria mercenaria

Qing Wang; Tao Zhang

doi:10.1007/s00343-011-0155-y

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The role of phosphatidylinositol signaling pathway in regulating serotonin-induced oocyte maturation in Mercenaria mercenaria

OriginalPaper | Updated：2023-05-16

- The role of phosphatidylinositol signaling pathway in regulating serotonin-induced oocyte maturation in Mercenaria mercenaria
- The role of phosphatidylinositol signaling pathway in regulating serotonin-induced oocyte maturation in Mercenaria mercenaria
- 海洋湖沼学报（英文） 2011年29卷第3期页码：568-575
- Affiliations：
  
  1. Institute of Oceanology Chinese Academy of Sciences
  2. Graduate University of Chinese Academy of Sciences
- Author bio：
- Funds：
  
  Supported by the National High Tecnhology Research and Development Program of China (863 Program) (No. 2004AA603810)
- DOI：10.1007/s00343-011-0155-y
  中图分类号：
- 网络首发：2011-05-15，
  
  纸质出版：2011
- Accepted：
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The role of phosphatidylinositol signaling pathway in regulating serotonin-induced oocyte maturation in Mercenaria mercenaria[J]. 海洋湖沼学报（英文）, 2011,29(3):568-575.

Wang, Q., Zhang, T. The role of phosphatidylinositol signaling pathway in regulating serotonin-induced oocyte maturation in Mercenaria mercenaria, ., Chin. J. Ocean. Limnol. 29, 568–575 (2011). https://doi.org/10.1007/s00343-011-0155-y
The role of phosphatidylinositol signaling pathway in regulating serotonin-induced oocyte maturation in Mercenaria mercenaria[J]. 海洋湖沼学报（英文）, 2011,29(3):568-575. DOI： 10.1007/s00343-011-0155-y.

Wang, Q., Zhang, T. The role of phosphatidylinositol signaling pathway in regulating serotonin-induced oocyte maturation in Mercenaria mercenaria, ., Chin. J. Ocean. Limnol. 29, 568–575 (2011). https://doi.org/10.1007/s00343-011-0155-y DOI：

摘要

Abstract

Serotonin (5-HT) has been found to stimulate meiotic maturation of oocytes in many molluscs. During maturation

several signaling pathways are involved

especially the phosphatidylinositol and cAMP pathways. In order to examine the possible role of the phosphatidylinositol signaling pathway in regulating oocyte maturation in Mercenaria mercenaria

the effects of the activator/inhibitor of phospholipase (PLC) and protein kinase C (PKC) on serotonin-induced maturation were studied. Results show that high-concentrations of neomycin (inhibitor of PLC) blocked oocyte maturation

while 9

10-dimethyl-1

2-benzanthracene (DMBA

activator of PLC) promoted oocyte maturation in the presence of serotonin. It was also found that in the presence of serotonin

phorbol 12-myristate 13-acetate (PMA

activator of PKC) inhibited oocyte maturation

while sphingosine (inhibitor of PKC) stimulated oocyte maturation. These results indicate that serotonin-induced oocyte maturation requires the activation of the phosphatidylinositol pathway. Decrease of PLC inhibited serotonin-induced oocyte maturation

whereas a decrease of PKC stimulated the maturation. Thus

our study indicates that serotonin promotes maturation of M. mercenaria oocytes through PLC stimulated increase in calcium ion concentration via inositol-1

5-trisphosphate (IP3) but not PKC.

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references

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