Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor

Dayong Shi; Xiaohong Li; Jing Li; Shuju Guo; Hua Su; Xiao Fan

doi:10.1007/s00343-010-9213-0

Your Location：

Home >

Browse articles >

Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor

OriginalPaper | Updated：2023-05-16

- Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor
- Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor
- 海洋湖沼学报（英文） 2010年28卷第1期页码：96-98
- Affiliations：
  
  1. Institute of Oceanology Chinese Academy of Sciences
  2. Qingdao Municipal Hospital
- Author bio：
- Funds：
  
  Supported by the National High Technology Research and Development Program of China (863 Program) (No. 2007AA09Z410) and the National Major Research Program of China “The Creation for Significant Innovative Drugs” (No. 2009ZX09103-148)
- DOI：10.1007/s00343-010-9213-0
  中图分类号：
- 网络首发：2010-01-27，
  
  纸质出版：2010
- Accepted：
Scan QR Code
Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor[J]. 海洋湖沼学报（英文）, 2010,28(1):96-98.

Shi, D., Li, X., Li, J. et al. Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor., Chin. J. Ocean. Limnol. 28, 96–98 (2010). https://doi.org/10.1007/s00343-010-9213-0
Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor[J]. 海洋湖沼学报（英文）, 2010,28(1):96-98. DOI： 10.1007/s00343-010-9213-0.

Shi, D., Li, X., Li, J. et al. Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor., Chin. J. Ocean. Limnol. 28, 96–98 (2010). https://doi.org/10.1007/s00343-010-9213-0 DOI：

摘要

Abstract

Thrombin

the ultimate proteinase of the coagulation cascade

is an attractive target for the treatment of a variety of cardiovascular diseases. A bromophenol derivative named (+)-3-(2

3-dibromo-4

5-dihydroxy-phenyl)-4-bromo-5

6-dihydroxy-1

3-dihydroiso-benzofuran 1

isolated from the brown alga Leathesia nana exhibited significant thrombin inhibitory activity. In this study

we investigated the inhibition of human thrombin in vitro with this bromophenol derivative

and its antithrombotic efficacy in vivo using the arteriovenous shunt model and the ferric chloride-induced arterial thrombosis model in rats. The results show that the bromophenol derivative is a potential inhibitor of thrombin (IC50=1.03 nmol/L). In antithrombotic experiments in vivo

the bromophenol derivative also shows good effect comparing with the control group. These data indicate that the bromophenol derivative is a potential drug for prophylaxis and the treatment of thrombotic diseases.

关键词

Keywords

references

DiMaio J, Gibbs B, Munn D, et al. 1990. Bifunctional thrombin inhibitors based on the sequence of hirudin 45–65. J. Biol. Chem., 265: 21 698–21 703.

Fan X, Xu N J, Shi J G. 2003a. Bromophenols from the red alga Rhodomela confervoides. J. Nat. Prod., 66:455–458.

Fan X, Xu N J, Shi J G. 2003b. Two new bromophenols from red alga Rhodomela confervoids. Chin. Chem. Lett., 14(9): 939–941.

Kurz K D, Main B W, Sandusky G E. 1990. Rat model of arterial thrombosis induced by ferric chloride. Thromb. Res., 60: 269–280.

Umetsu T, Sanai K. 1978. Effect of 1-methyl-2-mercapto-5-(3-pyridyl)-imidazole (KC-6141), anti-aggregating compound, on experimental thrombosis in rats. Thromb. Haemost., 39: 74–83.

Vlasuk G P. 1993. Structural and functional characterization of tick anticoagulant peptide (TAP) a potent and selective inhibitor of blood coagulation factor Xa. Thromb. Haemost., 70: 212–216.

Xu X L, Song F H, Wang S J, et al. 2004. Dibenzyl bromophenols with diverse dimerization patterns from the brown alga Leathesia nana. J. Nat. Prod., 67: 1 661–1 666.

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

暂无数据