Preparation and biological efficacy of haddock bone calcium tablets

Jiancong Huo; Shanggui Deng; Chao Xie; Guozhong Tong

doi:10.1007/s00343-010-9019-0

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Preparation and biological efficacy of haddock bone calcium tablets

OriginalPaper | Updated：2023-05-16

- Preparation and biological efficacy of haddock bone calcium tablets
- Preparation and biological efficacy of haddock bone calcium tablets
- 海洋湖沼学报（英文） 2010年28卷第2期页码：371-378
- Affiliations：
  
  College of Food and Pharmacology Zhejiang Ocean University
- Author bio：
- Funds：
  
  Supported by the Major Technology Project of Zhejiang Province (No. 2007C12013).
- DOI：10.1007/s00343-010-9019-0
  中图分类号：
- 网络首发：2010-03-20，
  
  纸质出版：2010
- Accepted：
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Preparation and biological efficacy of haddock bone calcium tablets[J]. 海洋湖沼学报（英文）, 2010,28(2):371-378.

Huo, J., Deng, S., Xie, C. et al. Preparation and biological efficacy of haddock bone calcium tablets., Chin. J. Ocean. Limnol. 28, 371–378 (2010). https://doi.org/10.1007/s00343-010-9019-0
Preparation and biological efficacy of haddock bone calcium tablets[J]. 海洋湖沼学报（英文）, 2010,28(2):371-378. DOI： 10.1007/s00343-010-9019-0.

Huo, J., Deng, S., Xie, C. et al. Preparation and biological efficacy of haddock bone calcium tablets., Chin. J. Ocean. Limnol. 28, 371–378 (2010). https://doi.org/10.1007/s00343-010-9019-0 DOI：

摘要

Abstract

To investigate the possible use of waste products obtained after processing haddock

the present study prepared haddock bone calcium powder by NaOH and ethanol soaking (alkalinealcohol method) and prepared haddock bone calcium tablets using the powder in combination with appropriate excipients. The biological efficacy of the haddock bone calcium tablets was investigated using Wistar rats as an experiment model. Results show that the optimal parameters for the alkalinealcohol method are: NaOH concentration 1 mol/L

immersion time 30 h; ethanol concentration 60%

immersion time 15 h. A mixture of 2% polyvinylpyrrolidone in ethanol was used as an excipient at a ratio of 1:2 to full-cream milk powder

without the use of a disintegrating agent. This process provided satisfactory tablets in terms of rigidity and taste. Animal studies showed that the haddock bone calcium tablets at a dose of 2 g·kg−1·d−1 or 5g·kg−1·d−1 significantly increased blood calcium and phosphorus levels and bone calcium content in rats. Therefore

these tablets could be used for calcium supplementation and prevent osteoporosis. Although the reasons of high absorption in the rats fed with haddock bone calcium tablets are unclear

it is suggested that there are some factors

such as treatment with method of alkaline-alcohol or the added milk

may play positive roles in increasing absorption ratio.

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references

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