In vivo effects of 17-β-estradiol on plasma immunoglobulin levels and leukocyte density in zebrafish Danio rerio

Lei Li; Shicui Zhang; Zhou Tong; Jia Liu

doi:10.1007/s00343-009-9048-8

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In vivo effects of 17-β-estradiol on plasma immunoglobulin levels and leukocyte density in zebrafish Danio rerio

OriginalPaper | Updated：2023-05-16

- In vivo effects of 17-β-estradiol on plasma immunoglobulin levels and leukocyte density in zebrafish Danio rerio
- In vivo effects of 17-β-estradiol on plasma immunoglobulin levels and leukocyte density in zebrafish Danio rerio
- 海洋湖沼学报（英文） 2010年28卷第3期页码：527-532
- Affiliations：
  
  Department of Marine Biology Ocean University of China
- Author bio：
- Funds：
  
  Supported by the Natural Science Foundation of Shandong Province (No. 2007ZRB02238), and the Natural Science Foundation of Qingdao Municipality (No. 06-2-2-15-jch)
- DOI：10.1007/s00343-009-9048-8
  中图分类号：
- 网络首发：2010-05-20，
  
  纸质出版：2010
- Accepted：
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In vivo effects of 17-β-estradiol on plasma immunoglobulin levels and leukocyte density in zebrafish Danio rerio[J]. 海洋湖沼学报（英文）, 2010,28(3):527-532.

Li, L., Zhang, S., Tong, Z. et al. In vivo effects of 17-β-estradiol on plasma immunoglobulin levels and leukocyte density in zebrafish Danio rerio, ., Chin. J. Ocean. Limnol. 28, 527–532 (2010). https://doi.org/10.1007/s00343-009-9048-8
In vivo effects of 17-β-estradiol on plasma immunoglobulin levels and leukocyte density in zebrafish Danio rerio[J]. 海洋湖沼学报（英文）, 2010,28(3):527-532. DOI： 10.1007/s00343-009-9048-8.

Li, L., Zhang, S., Tong, Z. et al. In vivo effects of 17-β-estradiol on plasma immunoglobulin levels and leukocyte density in zebrafish Danio rerio, ., Chin. J. Ocean. Limnol. 28, 527–532 (2010). https://doi.org/10.1007/s00343-009-9048-8 DOI：

摘要

Abstract

Estradiol

or 17-β-estradiol (E2)

the most potent naturally occurring estrogen

is involved in the hormone-immune system interaction in both mammals and fish. However

in vivo studies are largely limited

and little is known about whether E2 exerts similar effects on both female and male zebrafish (Danio rerio). Here

we show exposure of both sexes of D. rerio to 20 nmol/L E2 resulted in a significant increase in Vg1 expression

but caused little damage to the hepatocytes

suggesting that this is the optimum E2 concentration. Also

exposure to 20 nmol/L E2 for 20 days caused a marked increase in plasma IgM levels

but had little influence on the peripheral leukocyte density

providing the first evidence of a hormone-immune system interaction in this species.

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references

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