Study on extraction of agaropectin from Gelidium amansii and its anticoagulant activity

Huimin Qi; Daxin Li; Jingjing Zhang; Li Liu; Quanbin Zhang

doi:10.1007/s00343-008-0186-1

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Study on extraction of agaropectin from Gelidium amansii and its anticoagulant activity

OriginalPaper | Updated：2023-05-16

- Study on extraction of agaropectin from Gelidium amansii and its anticoagulant activity
- Study on extraction of agaropectin from Gelidium amansii and its anticoagulant activity
- 海洋湖沼学报（英文） 2008年26卷第2期页码：186-189
- Affiliations：
  
  1. Institute of Oceanology Chinese Academy of Sciences
  2. Weifang Medical University
  3. Shandong Provincial Pharmaceutical Co
- Author bio：
- Funds：
  
  Supported by the Innovative Key Project of Chinese Academy of Sciences (KZCX2-YW-209) and the Department of Science and Technology of Shandong Province (2007BS07004)
- DOI：10.1007/s00343-008-0186-1
  中图分类号：
- 网络首发：2008-05-28，
  
  纸质出版：2008
- Accepted：
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Study on extraction of agaropectin from Gelidium amansii and its anticoagulant activity[J]. 海洋湖沼学报（英文）, 2008,26(2):186-189.

Qi, H., Li, D., Zhang, J. et al. Study on extraction of agaropectin from Gelidium amansii and its anticoagulant activity., Chin. J. Ocean. Limnol. 26, 186–189 (2008). https://doi.org/10.1007/s00343-008-0186-1
Study on extraction of agaropectin from Gelidium amansii and its anticoagulant activity[J]. 海洋湖沼学报（英文）, 2008,26(2):186-189. DOI： 10.1007/s00343-008-0186-1.

Qi, H., Li, D., Zhang, J. et al. Study on extraction of agaropectin from Gelidium amansii and its anticoagulant activity., Chin. J. Ocean. Limnol. 26, 186–189 (2008). https://doi.org/10.1007/s00343-008-0186-1 DOI：

摘要

Abstract

Gelidium amansii agar was fractionated on DEAE-cellulose and four fractions were obtained sequentially. The yields of 1.0 mol/L NaCl fraction and 2.5 mol/L NaCl fraction were 2.80% and 2.03%. They are highly sulfated agar

and named as agaropectin with sulfate content being 22.8% and 32.5%

respectively. The anticoagulant experiment results show that agaropectin could effectively prolong the coagulation time in a dose-dependent manner in vitro. Agaropection could be absorbed and effectively prolong the plasma coagulation time in vivo. After intragastric administration at the doses of 100

200

and 400 mg/kg·d in rats for 15 days

TT (thrombin time)

CT (coagulation time)

PT (prothrombin time)

and APTT (activated partial thromboplastin time) could be effectively prolonged and the plasma Fib level could be significantly lowered.

关键词

Keywords

references

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