Protective effect of topically applied polypeptide fromChlamys farreri against ultraviolet radiation-induced chronic skin damage in guinea pig

Chi Mingliang; Cao Pengli; Yu Guoying; Zhu Li; Wang Yuejun; Wang Chunbo

doi:10.1007/BF02860426

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Protective effect of topically applied polypeptide fromChlamys farreri against ultraviolet radiation-induced chronic skin damage in guinea pig

OriginalPaper | Updated：2023-05-16

- Protective effect of topically applied polypeptide fromChlamys farreri against ultraviolet radiation-induced chronic skin damage in guinea pig
- Protective effect of topically applied polypeptide fromChlamys farreri against ultraviolet radiation-induced chronic skin damage in guinea pig
- 海洋湖沼学报（英文） 2003年21卷第4期页码：319-323
- Affiliations：
  
  Medical College Qingdao University
- Author bio：
- Funds：
  
  Project No. 39970638 supported by the NSFC, and the Science and Technology Bureau of Qingdao (No. 2001-28-50).
- DOI：10.1007/BF02860426
  中图分类号：
- 网络首发：2013-01-31，
  
  纸质出版：2003
- Accepted：
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Protective effect of topically applied polypeptide fromChlamys farreri against ultraviolet radiation-induced chronic skin damage in guinea pig[J]. 海洋湖沼学报（英文）, 2003,21(4):319-323.

Mingliang, C., Pengli, C., Guoying, Y. et al. Protective effect of topically applied polypeptide fromChlamys farreri against ultraviolet radiation-induced chronic skin damage in guinea pig., Chin. J. Ocean. Limnol. 21, 319–323 (2003). https://doi.org/10.1007/BF02860426
Protective effect of topically applied polypeptide fromChlamys farreri against ultraviolet radiation-induced chronic skin damage in guinea pig[J]. 海洋湖沼学报（英文）, 2003,21(4):319-323. DOI： 10.1007/BF02860426.

Mingliang, C., Pengli, C., Guoying, Y. et al. Protective effect of topically applied polypeptide fromChlamys farreri against ultraviolet radiation-induced chronic skin damage in guinea pig., Chin. J. Ocean. Limnol. 21, 319–323 (2003). https://doi.org/10.1007/BF02860426 DOI：

摘要

Abstract

Polypeptide fromChlamys farreri (PCF)

a topical polypeptide isolated fromChlamys farreri

was used in this experiment aimed to investigate the photoprotective effect of PCF against chronic skin damage induced by ultraviolet A (UVA) and ultraviolet B (UVB) radiation. The chronic ultraviolet-irradiated guinea pig model was established

and visible changes in the skin including wrinkling

sagging and erythema were observed. Malondialdehyde (MDA) and antioxidant enzymes including superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) in the dorsal skin were determined using biochemical methods. The results showed: (1) PCF (5 % and 20%) could greatly protect the dorsal skin of guinea pig against wrinkling

sagging and erythema induced by UV radiation in a concentration-dependent manner. (2) PCF could reduce MDA formation in the dorsal skin caused by UV irradiation

while increasing the activities of SOD and GSH-px. (3) The differences among the PCF groups and UV model group were significant (P<0.05

P<0.01). These results indicated that topical application

of PCF provided broad solar UV spectrum photoprotection; and that the antioxidant property of PCF might play a role in photoprotection.

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references

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