Antitumor and immune regulation activities of the extracts of some Chinese marine invertebrates

Zhang Lixin; Fan Xiao; Han Lijun

doi:10.1007/BF02845151

Your Location：

Home >

Browse articles >

Antitumor and immune regulation activities of the extracts of some Chinese marine invertebrates

OriginalPaper | Updated：2023-05-16

- Antitumor and immune regulation activities of the extracts of some Chinese marine invertebrates
- Antitumor and immune regulation activities of the extracts of some Chinese marine invertebrates
- 海洋湖沼学报（英文） 2005年23卷第1期页码：110-117
- Affiliations：
  
  1. Institute of Oceanology Chinese Academy of Sciences
  2. College of Chemistry Engineering Qingdao University
  3. Graduated School of the Chinese Academy of Sciences
- Author bio：
- Funds：
  
  Supported by HTRDPC Projects (2001 AA620403, 503) and Key Innovative Project of the Chinese Academy of Sciences (KZCX3-SW-215).
- DOI：10.1007/BF02845151
  中图分类号：
- 纸质出版：2005
- Accepted：
Scan QR Code
Antitumor and immune regulation activities of the extracts of some Chinese marine invertebrates[J]. 海洋湖沼学报（英文）, 2005,23(1):110-117.

Lixin, Z., Xiao, F. & Lijun, H. Antitumor and immune regulation activities of the extracts of some Chinese marine invertebrates., Chin. J. Ocean. Limnol. 23, 110–117 (2005). https://doi.org/10.1007/BF02845151
Antitumor and immune regulation activities of the extracts of some Chinese marine invertebrates[J]. 海洋湖沼学报（英文）, 2005,23(1):110-117. DOI： 10.1007/BF02845151.

Lixin, Z., Xiao, F. & Lijun, H. Antitumor and immune regulation activities of the extracts of some Chinese marine invertebrates., Chin. J. Ocean. Limnol. 23, 110–117 (2005). https://doi.org/10.1007/BF02845151 DOI：

摘要

Abstract

Extracts of 21 marine invertebrates belonging to Coelenterata

Mollusca

Annelida

Bryozoa

Echiura

Arthropoda

Echinodermata and Urochordata were screened for the studies on their antitumor and immune regulation activities. Antitumor activity was determined by MTT method and immune regulation activity was studied using T- and B-lymphocytes in mice spleenin vitro. It was found that the n-butanol part ofAsterina pectinifera

the acetic ether part ofTubuaria marina

95% ethanol extract ofAcanthochiton rubrolineatus have a high inhibition rate of 96.7%

63.9% and 50.5% respectively on tumor cell line HL-60 at the concentration of 0.063 mg/ml. The inhibition rate of the acetic ether part ofTubuaria marina on the tumor cell line A-549 is 65.4% at concentration of 0.063 mg/mL. The 95% ethanol extract ofMeretrix meretrix has so outstanding promoting effect on T-lymphocytes that their multiplication increases 25% when the sample concentration is only 1 μg/ml. On B-lymphocytes

the 95% extract ofRapana venosa

at concentration of 100 μg/ml

has a promotion percentage of 60%. On the other hand

under the condition of no cytotoxic effect

the 95% ethanol extracts ofAcanthochiton rubrolineatus andCellana toreum can reach 92% inhibition rate on T lymphocyte at concentration of 100 μg/ml

while the inhibition rate on B lymphocyte of the 95% extract ofAcanthochiton rubrolineatus reaches 92% at the same concentration.

关键词

Keywords

references

Dou, C. G., F. Huang and L. S. Huang, 1999. An experimental study on the effects ofMeretrix polysaccharide on antineoplastic and immunoregulation.Chinese Marine Drug 2:15 (in Chinese).

Choi, D. H., S. Shin and I. K. Park, 1999. Characterization of antimicrobial agents extracted fromAsterina pectinifera.International Journal of Antimicrobial Agents 11:65.

Han, R., 1991. Chemoprophylaxis and Medication of Tumor. United Publishing Company of Beijing Medical University and Chinese Xiehe Medical University, Beijing. 16p.

Towle, M. J., K. A. Salvato and J. Budrow, 2001. In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B.Cancer Res. 61(3):1013–1021.

Jia, Y. H., 1995. Chinese Marine Pharmacology. Xueyuan Publishing Company, Beijing, China. 120p. (in Chinese)

Jiang, F. W. and Y. S. Zhang, 1994. Chinese Marine Drug Dictionary. Ocean Publishing Company, 271p. (in Chinese)

Kraft, A. S., S. Woodley, G. R. Pettit, F. Gao, J. C. Coll and F. Wagner, 1996. Comparison of the antitumor activity of bryostatins 1, 5, and 8.Cancer Chemother. Pharmacol. 37:271–178.

Luo, Y. M., D. M. Wu and D. S. Ni, 1996. Pharmacologic effects of flesh of the clamMeretrix meretrix.Chinese Marine Drug 2:14 (in Chinese).

Mohammad, R. M., M. L. Varterasean, V. P. Almatchy, G. N. Hannoudi, G. R. Pettit and A. Al-Katib, 1998. Successful treatment of human chronic lymphocytic leukemia xenografts with combination biological agents auristatin PE and bryostatin 1.Clin. Cancer res. 4:1337–1343.

Yang, D. J. and Y. L. Wang, 1996. Chinese Northern Marine Invertebrates. High Education Publishing Company, Beijing.

Yu, Z. L., C. G. Dou and W. J. Jiang, 1994. Anti-mutation activity ofMeretrix meretrix.Chinese Marine Drug 2:34. (in Chinese)

Zhou, P., Q. Q. Gu and C. Y. Wang, 2000. The development of starfish and other activity components.Marine Sciences 24:35.

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Genome-wide evolution of MAPKs family and their expression in response to bacterial infection in seahorse Hippocampus erectus

Isolation and pharmacological activities of bromophenols fromRhodomela confervoides

Roles of polysaccharide from Branchiostoma belcheri in anti-DNA oxidation and anti-tumor activity in S180 mice

The antitumor effect of bromophenol derivatives in vitro and Leathesia nana extract in vivo

导流锥结构参数对燃气弹射筒内压力冲击平滑效果影响研究