Studies on the antitumor activity and isolation of the glycoprotein from the gonad ofChlamys (Azumapecten) farreri

Gu Qian-qun; Fang Yu-chun; Wang Chang-yun; Xiao Hang; Qin Yu-qing

doi:10.1007/BF02844933

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Studies on the antitumor activity and isolation of the glycoprotein from the gonad ofChlamys (Azumapecten) farreri

OriginalPaper | Updated：2023-05-16

- Studies on the antitumor activity and isolation of the glycoprotein from the gonad ofChlamys (Azumapecten) farreri
- Studies on the antitumor activity and isolation of the glycoprotein from the gonad ofChlamys (Azumapecten) farreri
- 海洋湖沼学报（英文） 1998年16卷第4期页码：359-363
- Affiliations：
  
  Institute of Marine Drugs and Foods
- Author bio：
- Funds：
- DOI：10.1007/BF02844933
  中图分类号：
- 纸质出版：1998
- Accepted：
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Studies on the antitumor activity and isolation of the glycoprotein from the gonad ofChlamys (Azumapecten) farreri[J]. 海洋湖沼学报（英文）, 1998,16(4):359-363.

Qian-qun, G., Yu-chun, F., Chang-yun, W. et al. Studies on the antitumor activity and isolation of the glycoprotein from the gonad ofChlamys (Azumapecten) farreri, ., Chin. J. Ocean. Limnol. 16, 359–363 (1998). https://doi.org/10.1007/BF02844933
Studies on the antitumor activity and isolation of the glycoprotein from the gonad ofChlamys (Azumapecten) farreri[J]. 海洋湖沼学报（英文）, 1998,16(4):359-363. DOI： 10.1007/BF02844933.

Qian-qun, G., Yu-chun, F., Chang-yun, W. et al. Studies on the antitumor activity and isolation of the glycoprotein from the gonad ofChlamys (Azumapecten) farreri, ., Chin. J. Ocean. Limnol. 16, 359–363 (1998). https://doi.org/10.1007/BF02844933 DOI：

摘要

Abstract

After being degreased with acetone

the female gonad ofChlamys (Azumapecten) farreri was extracted with water

and then subjected to DEAE—cellulose column chromatography and purified by Sephadex G-100 chromatography to obtain a pure female gonad glycoprotein (FGGP). The IR spectra

electrophoresis and chemical analysis of FGGP indicated that it was a kind of acid glycoprotein and that the content of total protein and sugar were 54.8% and 40%

respectively. Pharmacological tests showed that FGGP could inhibit (inhibition rate of 40.87%) the growth of Sarcoma 180 of mice.

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references

Dong Qun, 1996. Modified phenol-sulfuric acid method for determination of the content of oligo-and polysaccharide.Chinese Pharmaceutical Journal 31(92): 550–553. (in Chinese, with English abstract)

Gu Qianqun, 1996. Preliminary studies on the antitumor activity of glycoprotein fromChlamys (Azumapecten) farreri. 1st National Symposium on Marine Bioactive Substances and Natural Medicines. p. 502–504. (in Chinese, with English abstract)

Huang Weikun, 1991. Analysis and Inspection of Food. Shanghai Science Press, Shanghai, p. 66–68.

Kamiya H., Muramoto K., 1988. Studies on bioactive marine metabolites-VII characterization of the antibacterial and antineoplastic glycoprotein in a sea hareAplysia juliana.Nippon Susan Gakkaishi 54(5):737–777.

Kisugi J., Ohye H., Kamiya H., 1989. Biopolymers from marine invertebrates, X. mode of action of an antibacterial glycoprotein, aplysianin E, from eggs of a sea hare,Aplysia kurodal, Chem. Pharm. Bull. 37(11):3050–3053.

Kobata A, 1992. Structure of glycoprotein and effect on living organism.Modern Chemistry.8: 14–19. (in Japanese)

Takuma S., Hiroyuki U., Noriko A., 1987. Antitumor activity and immunomo-dulatory effect of glycoprotein fraction from scallopPatinopecten yessoensis.Nippon Susan Gakkaish 53(2):267–272.

Takuma S., Noriko A., Hiroyuki U., 1985. Antitumor activity of aqueous extracts of marine animals.J. Pharmacobio-Dyn. 8:996–974.

Wan Jianrong, 1989. Clinical analysis of aquatic product food. Light Industry Press, Beijing, p. 51–52.

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