Comparative study of the hemolytic and cytotoxic activities of nematocyst venoms from the jellyfish <italic style="font-style: italic">Cyanea nozakii</italic> Kishinouye and <italic style="font-style: italic">Nemopilema nomurai</italic> Kishinouye

Min PANG; Jintao XU; Yunlong LIU; Xuelei ZHANG

doi:10.1007/s00343-018-7104-y

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Comparative study of the hemolytic and cytotoxic activities of nematocyst venoms from the jellyfish Cyanea nozakii Kishinouye and Nemopilema nomurai Kishinouye

Updated：2023-05-19

- Comparative study of the hemolytic and cytotoxic activities of nematocyst venoms from the jellyfish Cyanea nozakii Kishinouye and Nemopilema nomurai Kishinouye
- Chinese Journal of Oceanology and Limnology Vol. 36, Issue 4, Pages: 1255-1265(2018)
- Affiliations：
  
  1.Key Laboratary of Science and Engineering for Marine Ecology and Environment, First Institute of Oceanography, State Oceanic Administration, Qingdao 266003, China
  2.Laboratory of Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266200, China
  3.Qinhuangdao Marine Environmental Monitoring Central Station of SOA, Qinhuangdao 066000, China
  4.Chinese Research Academy of Environmental Sciences, Beijing 100012, China
- Author bio：
  
  ZHANG Xuelei, zhangxl@fio.org.cn
- Funds：
- DOI：10.1007/s00343-018-7104-y
  CLC：
- Received：30 March 2017，
  
  Accepted：27 May 2017，
  
  Online First：13 July 2017，
  
  Published：2018-07
- Accepted：
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Min PANG, Jintao XU, Yunlong LIU, et al. Comparative study of the hemolytic and cytotoxic activities of nematocyst venoms from the jellyfish Cyanea nozakii Kishinouye and Nemopilema nomurai Kishinouye[J]. Chinese Journal of Oceanology and Limnology, 2018, 36(4): 1255-1265.
DOI：

Min PANG, Jintao XU, Yunlong LIU, et al. Comparative study of the hemolytic and cytotoxic activities of nematocyst venoms from the jellyfish Cyanea nozakii Kishinouye and Nemopilema nomurai Kishinouye[J]. Chinese Journal of Oceanology and Limnology, 2018, 36(4): 1255-1265. DOI： 10.1007/s00343-018-7104-y.

摘要

Abstract

Two species of jellyfish

Cyanea nozakii

Kishinouye and

Nemopilema nomurai

Kishinouye

have occurred off coastal areas of the northeastern China Sea

Yellow Sea

and Bohai Sea in recent years. They influence marine ecosystem safety and fishery production

and also pose a risk to human health. The current study examined the hemolytic and cytotoxic activities of crude venoms extracted from the nematocysts of

C. nozakii

and

N. nomurai

. The results showed that there were more nematocysts on tentacles from

C. nozakii

than on tentacles of the same length from

N. nomurai

. The protein concentration per nematocyst extracted from

N. nomurai

was higher than that from

C. nozakii

. Both nematocyst venoms showed dose- and timedependent hemolytic activity on erythrocytes from chicken

pigeon

and sheep

with sheep erythrocytes being the most sensitive

with EC

values of 69.69 and 63.62 μg/mL over a 30-min exposure with

N. nomurai

and

C. nozakii

nematocyst venoms

respectively. A cytotoxic assay of both jellyfish venoms on A431 human epidermal carcinoma cells resulted in IC

values of 68.6 and 40.9 μg/mL after 24-h incubation

respectively

with venom from

C. nozakii

showing stronger cytotoxic activity than that from

N. nomurai

. The results of current study indicate that nematocyst venom from

C. nozakii

had stronger hemolytic and cytotoxic activities than that from

N. nomurai

and

thus

C. nozakii

might be more harmful to the health of humans and other species than are

N. nomurai

when they appear in coastal waters.

关键词

Keywords

references

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⁰

Comparative study of the hemolytic and cytotoxic activities of nematocyst venoms from the jellyfish Cyanea nozakii Kishinouye and Nemopilema nomurai Kishinouye

DOI：10.1007/s00343-018-7104-y

摘要

Abstract

关键词

Keywords

references