Polymorphisms in the Myostatin-1 gene and their association with growth traits in Ancherythroculter nigrocauda

Yanhong Sun; Qing Li; Guiying Wang; Dongmei Zhu; Jian Chen; Pei Li; Jingou Tong

doi:10.1007/s00343-017-5317-0

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Polymorphisms in the Myostatin-1 gene and their association with growth traits in Ancherythroculter nigrocauda

Updated：2023-05-16

- Polymorphisms in the Myostatin-1 gene and their association with growth traits in Ancherythroculter nigrocauda
- Journal of Oceanology and Limnology Vol. 35, Issue 3, Pages: 597-602(2017)
- Affiliations：
  
  1. Wuhan Aquaculture Science Research Institute
  2. State Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences
- Author bio：
- Funds：
- DOI：10.1007/s00343-017-5317-0
  CLC：
- Online First：26 May 2016，
  
  Published：2017
- Accepted：
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Sun, Y., Li, Q., Wang, G. et al. Polymorphisms in the Myostatin-1 gene and their association with growth traits in Ancherythroculter nigrocauda, ., Chin. J. Ocean. Limnol. 35, 597–602 (2017). https://doi.org/10.1007/s00343-017-5317-0
DOI：

Sun, Y., Li, Q., Wang, G. et al. Polymorphisms in the Myostatin-1 gene and their association with growth traits in Ancherythroculter nigrocauda, ., Chin. J. Ocean. Limnol. 35, 597–602 (2017). https://doi.org/10.1007/s00343-017-5317-0 DOI：

摘要

Abstract

Myostatin (MSTN) is a member of the transforming growth factor-β gene superfamily that negatively regulates skeletal muscle development and growth. In the present study

partial genomic fragments of Myostatin-1 (MSTN-1) in two commercial hatchery populations of Ancherythroculter nigrocauda

an economically important freshwater fish

were screened for single nucleotide polymorphisms (SNPs) and then genotyped by direct sequencing of PCR products. Five SNPs were identified in intron 1 and exon 2

including a non-synonymous mutation causing an amino acid change (Val to Ile) at position 180. Association analyses based on 300 individuals revealed that the g.1129T>C SNP locus was significantly associated with total length (TL)

body length (BL)

body height (BH) and body weight (BW) in 6- and 18-month-old populations

while the g.1289G>A locus was significantly associated with BH and BW in the 6-month-old population. Haplotype analyses revealed that fish with the genotype combinations TC/TC or TC/GA showed better growth performance. Our results suggest that g.1129T>C and g.1289G>A have positive effects on growth traits and may be candidate gene markers for marker-assisted selection in A. nigrocauda.

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references

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