Effects of dietary genistein on GH/IGF-I axis of Nile tilapia Oreochromis niloticus

Dong Chen; Wei Wang; Shaoguo Ru

doi:10.1007/s00343-016-4386-9

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Effects of dietary genistein on GH/IGF-I axis of Nile tilapia Oreochromis niloticus

Updated：2023-05-16

- Effects of dietary genistein on GH/IGF-I axis of Nile tilapia Oreochromis niloticus
- Journal of Oceanology and Limnology Vol. 34, Issue 5, Pages: 1004-1012(2016)
- Affiliations：
  
  1. College of Marine Life Sciences Ocean University of China
  2. School of Environmental and Municipal Engineering Qingdao Technological University
- Author bio：
- Funds：
- DOI：10.1007/s00343-016-4386-9
  CLC：
- Online First：28 January 2016，
  
  Published：2016
- Accepted：
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Chen, D., Wang, W. & Ru, S. Effects of dietary genistein on GH/IGF-I axis of Nile tilapia Oreochromis niloticus, ., Chin. J. Ocean. Limnol. 34, 1004–1012 (2016). https://doi.org/10.1007/s00343-016-4386-9
DOI：

Chen, D., Wang, W. & Ru, S. Effects of dietary genistein on GH/IGF-I axis of Nile tilapia Oreochromis niloticus, ., Chin. J. Ocean. Limnol. 34, 1004–1012 (2016). https://doi.org/10.1007/s00343-016-4386-9 DOI：

摘要

Abstract

There is considerable concern that isoflavones

such as genistein in fish feed composed of soybean protein

aff ects somatic growth in fish. Our previous works demonstrated that 30 and 300 μg/g dietary genistein had no significant eff ect on growth performance in Nile tilapia (Oreochromis niloticus)

but the higher level of genistein (3 000 μg/g) significantly depressed growth. This study was conducted to further examine the eff ects of dietary genistein on the endocrine disruption on growth hormone/insulin-like growth factor-I (GH/IGF-I) axis in Nile tilapia (O. niloticus). Juvenile fish were fed by hand twice daily to satiation with one of four isonitrogenous and isoenergetic diets

each containing either 0

300 or 3 000 μg/g genistein. Following an 8-week feeding period

plasma GH and IGF-I levels were investigated by radioimmunoassay and gene expression levels of gh

ghrelin

gnrhs

ghr

npy

npyrs

pacap

ghrs

igf-I

igf-Ir

and igfbp3 were examined by real-time PCR. The results show that no significant change in plasma GH and IGF-I levels in fish fed with diets containing 30 μg/g and 300 μg/g genistein. mRNA expression of genes along the GH/IGF-I axis remained unaff ected

except for igf-Ir

which was stimulated by the 300 μg/g genistein diet. While in fish fed the 3 000 μg/g genistein diet

the plasma GH and IGF-I levels decreased

and mRNA expression of gh

ghr2

npyr1

igf-I

and igf-Ir were also significantly depressed. In contrast

npy and igfbp3 mRNA expression were enhanced. This study provides convincing evidence for growth impediment by genistein by disturbing the GH/IGF-I axis in Nile tilapia O. niloticus.

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