Pharmacokinetics and acetylation of sulfamethoxazole in turbot Scophthalmus maximus after intravascular administration

Zhiqiang Chang; Fei Liu; Chun’ang Lian; Qianqian Zhai; Jian Li

doi:10.1007/s00343-016-4310-3

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Pharmacokinetics and acetylation of sulfamethoxazole in turbot Scophthalmus maximus after intravascular administration

Updated：2023-05-16

- Pharmacokinetics and acetylation of sulfamethoxazole in turbot Scophthalmus maximus after intravascular administration
- Journal of Oceanology and Limnology Vol. 34, Issue 4, Pages: 789-794(2016)
- Affiliations：
  
  1. Key Laboratory of Sustainable Development of Marine Fisheries Ministry of Agriculture Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences
  2. College of Fisheries and Life Sciences Shanghai Ocean University
- Author bio：
- Funds：
- DOI：10.1007/s00343-016-4310-3
  CLC：
- Online First：19 November 2015，
  
  Published：2016
- Accepted：
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Chang, Z., Liu, F., Lian, C. et al. Pharmacokinetics and acetylation of sulfamethoxazole in turbot Scophthalmus maximus after intravascular administration., Chin. J. Ocean. Limnol. 34, 789–794 (2016). https://doi.org/10.1007/s00343-016-4310-3
DOI：

Chang, Z., Liu, F., Lian, C. et al. Pharmacokinetics and acetylation of sulfamethoxazole in turbot Scophthalmus maximus after intravascular administration., Chin. J. Ocean. Limnol. 34, 789–794 (2016). https://doi.org/10.1007/s00343-016-4310-3 DOI：

摘要

Abstract

The pharmacokinetic profiles and sulfamethoxazole (SMX) acetylation process in turbot reared at 18°C were investigated. Either SMX (parent drug) or its acetylized metabolite

N4-acetylsulfamethoxazole (AcSMX)

was administered intravascularly to turbot at a dosage of 50 mg/kg BW. Serum concentrations of the parent drug and its metabolite were both measured by HPLC

and the changes in concentration over time were analyzed in two- and non-compartment models because SMX treatment produced multiple peaks. The results demonstrated that the elimination half-life of the parent drugs

SMX and AcSMX

were 159.2 and 5.9 h

respectively. The apparent volume of distribution was 0.2 and 0.8 L/kg

and the clearance was 0.038 and 0.222 L/(h·kg)

for SMX and AcSMX

respectively. SMX acetylation in turbot was 2.8%

and the deacetylation of AcSMX was 0.2%. These findings may be useful in optimizing SMX dosage regimens in turbot aquaculture.

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references

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