Alkaloids from an algicolous strain of Talaromyces sp.

Haibin Yang; Fang Li; Naiyun Ji

doi:10.1007/s00343-015-4316-2

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Alkaloids from an algicolous strain of Talaromyces sp.

Updated：2023-05-16

- Alkaloids from an algicolous strain of Talaromyces sp.
- Journal of Oceanology and Limnology Vol. 34, Issue 2, Pages: 367-371(2016)
- Affiliations：
  
  1. College of Chemistry and Molecular Engineering Qingdao University of Science & Technology
  2. Key Laboratory of Coastal Biology and Bioresource Utilization Yantai Institute of Coastal Zone Research Chinese Academy of Sciences
- Author bio：
- Funds：
- DOI：10.1007/s00343-015-4316-2
  CLC：
- Online First：29 September 2015，
  
  Published：2016
- Accepted：
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Yang, H., Li, F. & Ji, N. Alkaloids from an algicolous strain of Talaromyces sp.., Chin. J. Ocean. Limnol. 34, 367–371 (2016). https://doi.org/10.1007/s00343-015-4316-2
DOI：

Yang, H., Li, F. & Ji, N. Alkaloids from an algicolous strain of Talaromyces sp.., Chin. J. Ocean. Limnol. 34, 367–371 (2016). https://doi.org/10.1007/s00343-015-4316-2 DOI：

摘要

Abstract

Compounds isolated and identified in a culture of the alga-endophytic fungus Talaromyces sp. cf-16 included two naturally occurring alkaloids

2-[(S)-hydroxy(phenyl)methyl]-3-methylquinazolin-4(3H)-one (1a) and 2-[(R)-hydroxy(phenyl)methyl]-3-methylquinazolin-4(3H)-one (1b)

that were identified for the first time. In addition

seven known compounds (2–8) were obtained from the culture. Following chiral column chromatography

compounds 1a and 1b were identified as enantiomers by spectroscopic analyses and quantum chemical calculations. Bioassay results showed that 5 was more toxic to brine shrimp than the other compounds

and that 3–6 could inhibit Staphylococcus aureus.

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references

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