Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms

Fei Li; Huifeng Wu; Qing Wang; Xuehua Li; Jianmin Zhao

doi:10.1007/s00343-015-4127-5

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Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms

Updated：2023-05-16

- Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms
- Journal of Oceanology and Limnology Vol. 33, Issue 3, Pages: 705-713(2015)
- Affiliations：
  
  1. Key Laboratory of Coastal Zone Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone Research (YIC) Chinese Academy of Sciences Shandong Provincial Key Laboratory of Coastal Zone Environmental Processes
  2. Key Laboratory of Industrial Ecology and Environmental Engineering (MOE) School of Environmental Science and Technology Dalian University of Technology
- Author bio：
- Funds：
- DOI：10.1007/s00343-015-4127-5
  CLC：
- Online First：08 January 2015，
  
  Published：2015
- Accepted：
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Li, F., Wu, H., Wang, Q. et al. Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms., Chin. J. Ocean. Limnol. 33, 705–713 (2015). https://doi.org/10.1007/s00343-015-4127-5
DOI：

Li, F., Wu, H., Wang, Q. et al. Glutathione S-transferase (GST) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms., Chin. J. Ocean. Limnol. 33, 705–713 (2015). https://doi.org/10.1007/s00343-015-4127-5 DOI：

摘要

Abstract

Glutathione S-transferases (GSTs) are phase II enzymes that facilitate the detoxification of xenobiotics and play important roles in antioxidant defense. We investigated the expression patterns of seven Venerupis philippinarum GSTs (VpGSTs) and four Mytilus galloprovincialis GSTs (MgGSTs) following exposure to BDE-47. Differential expressions of the seven VpGSTs and four Mg GSTs transcripts were observed

with differences between the hepatopancreas and gills. Among these GSTs

the sigma classes (VpGSTS1

VpGSTS2

VpGSTS3

MgGST1

and MgGST3) were highly expressed in response to BDE-47 exposure

demonstrating their potential as molecular biomarkers for environmental biomonitoring studies. We obtained the three-dimensional crystal structures of VpGSTs and MgGSTs by homologous modeling. A model to elucidate the binding interactions between the ligands and receptors was defined by molecular docking. Hydrophobic and π were the most often observed interactions between BDE-47 and the GSTs.

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references

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