Effects of BPA and E2 on expression profiles of genes related to hypothalamic-pituitary-gonadal axis of half-smooth tongue sole Cynoglossus semilaevis

Fengling Li; Zhaoxin Li; Qingyin Wang; Yuxiu Zhai

doi:10.1007/s00343-013-2232-x

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Effects of BPA and E2 on expression profiles of genes related to hypothalamic-pituitary-gonadal axis of half-smooth tongue sole Cynoglossus semilaevis

Updated：2023-05-16

- Effects of BPA and E2 on expression profiles of genes related to hypothalamic-pituitary-gonadal axis of half-smooth tongue sole Cynoglossus semilaevis
- Journal of Oceanology and Limnology Vol. 31, Issue 3, Pages: 598-608(2013)
- Affiliations：
  
  Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences
- Author bio：
- Funds：
- DOI：10.1007/s00343-013-2232-x
  CLC：
- Online First：08 May 2013，
  
  Published：2013
- Accepted：
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Li, F., Li, Z., Wang, Q. et al. Effects of BPA and E2 on expression profiles of genes related to hypothalamic-pituitary-gonadal axis of half-smooth tongue sole Cynoglossus semilaevis, ., Chin. J. Ocean. Limnol. 31, 598–608 (2013). https://doi.org/10.1007/s00343-013-2232-x
DOI：

Li, F., Li, Z., Wang, Q. et al. Effects of BPA and E2 on expression profiles of genes related to hypothalamic-pituitary-gonadal axis of half-smooth tongue sole Cynoglossus semilaevis, ., Chin. J. Ocean. Limnol. 31, 598–608 (2013). https://doi.org/10.1007/s00343-013-2232-x DOI：

摘要

Abstract

Endocrine disrupting chemicals (EDCs) are increasingly viewed as persistent pollutants

similar to natural hormones in function. This paper describes the expression profiles of 7 genes (DMRT

VTG GnRHR FSHR CYP17A CYP19A

and CYP19B) involved in sex steroid synthesis and action as well as sexual development in adult male and female Cynoglossus semilaevis

after exposure to different concentrations of Bisphenol A (BPA) and 17β-estradiol (E2). Both BPA (1

125

and 250 mg/kg) and E2 (0.5

and 10 mg/kg) induced changes in target gene expression

although the estrogenic effects of E2 as a model estrogen were stronger. Among the 7 genes

VTG CYP17A and CYP19 responded strongly to BPA or E2 exposure and can thus serve as reference biomarkers for estrogenic EDCs exposure in marine teleosts. These data will provide a window to establish a hypothalamic-pituitary-gonadal model in C. semilaevis to better understand the effect pathways of EDCs.

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references

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