Antiaging activity of low molecular weight peptide from Paphia undulate

Xin Chen; Bingna Cai; Hua Chen; Jianyu Pan; Deke Chen; Huili Sun

doi:10.1007/s00343-013-2222-z

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Antiaging activity of low molecular weight peptide from Paphia undulate

Updated：2023-05-16

- Antiaging activity of low molecular weight peptide from Paphia undulate
- Journal of Oceanology and Limnology Vol. 31, Issue 3, Pages: 570-580(2013)
- Affiliations：
  
  1. Science School of Foshan University
  2. Key Laboratory of Marine Bio-resources Sustainable Utilization South China Sea Institute of Oceanology Chinese Academy of Sciences
  3. Graduate University of Chinese Academy of Sciences
- Author bio：
- Funds：
- DOI：10.1007/s00343-013-2222-z
  CLC：
- Online First：08 May 2013，
  
  Published：2013
- Accepted：
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Chen, X., Cai, B., Chen, H. et al. Antiaging activity of low molecular weight peptide from Paphia undulate, ., Chin. J. Ocean. Limnol. 31, 570–580 (2013). https://doi.org/10.1007/s00343-013-2222-z
DOI：

Chen, X., Cai, B., Chen, H. et al. Antiaging activity of low molecular weight peptide from Paphia undulate, ., Chin. J. Ocean. Limnol. 31, 570–580 (2013). https://doi.org/10.1007/s00343-013-2222-z DOI：

摘要

Abstract

Low molecular weight peptide (LMWP) was prepared from clam Paphia undulate and its antiaging effect on D-galactose-induced acute aging in rats

aged Kunming mice

ultraviolet-exposed rats

and thermally injured rats was investigated. P. undulate flesh was homogenized and digested using papain under optimal conditions

then subjected to Sephadex G-25 chromatography to isolate the LMWP. Administration of LMWP significantly reversed D-galactose-induced oxidative stress by increasing the activities of glutathione peroxidase (GPx) and catalase (CAT)

and by decreasing the level of malondialdehyde (MDA). This process was accompanied by increased collagen synthesis. The LMWP prevented photoaging and promoted dermis recovery and remission of elastic fiber hyperplasia. Furthermore

treatment with the LMWP helped to regenerate elastic fibers and the collagen network

increased superoxide dismutase (SOD) in the serum and significantly decreased MDA. Thermal scald-induced inflammation and edema were also relieved by the LWMP

while wound healing in skin was promoted. These results suggest that the LMWP from P. undulate could serve as a new antiaging substance in cosmetics.

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