The influence of salinity on toxicological effects of arsenic in digestive gland of clam Ruditapes philippinarum using metabolomics

Chenglong Ji; Huifeng Wu; Xiaoli Liu; Jianmin Zhao; Junbao Yu; Xiuli Yin

doi:10.1007/s00343-013-2124-0

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The influence of salinity on toxicological effects of arsenic in digestive gland of clam Ruditapes philippinarum using metabolomics

Updated：2023-05-16

- The influence of salinity on toxicological effects of arsenic in digestive gland of clam Ruditapes philippinarum using metabolomics
- Journal of Oceanology and Limnology Vol. 31, Issue 2, Pages: 345-352(2013)
- Affiliations：
  
  1. Key Laboratory of Coastal Zone Environmental Processes Yantai Institute of Coastal Zone Research (YIC) Chinese Academy of Sciences (CAS)
  2. Shandong Provincial Key Laboratory of Coastal Zone Environmental Processes YICCAS
  3. Graduate University of Chinese Academy of Sciences
- Author bio：
- Funds：
- DOI：10.1007/s00343-013-2124-0
  CLC：
- Online First：07 March 2013，
  
  Published：2013
- Accepted：
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Ji, C., Wu, H., Liu, X. et al. The influence of salinity on toxicological effects of arsenic in digestive gland of clam Ruditapes philippinarum using metabolomics., Chin. J. Ocean. Limnol. 31, 345–352 (2013). https://doi.org/10.1007/s00343-013-2124-0
DOI：

Ji, C., Wu, H., Liu, X. et al. The influence of salinity on toxicological effects of arsenic in digestive gland of clam Ruditapes philippinarum using metabolomics., Chin. J. Ocean. Limnol. 31, 345–352 (2013). https://doi.org/10.1007/s00343-013-2124-0 DOI：

摘要

Abstract

Ruditapes philippinarum

a clam that thrives in intertidal zones of various salinities

is a useful biomonitor to marine contaminants. We investigated the influence of dilution to 75% and 50% of normal seawater salinity (31.1) on the responses of the digestive gland of R. philippinarum to arsenic exposure (20 μg/L)

using nuclear magnetic resonance (NMR)-based metabolomics. After acute arsenic exposure for 48 h

salinity-dependent differential metabolic responses were detected. In normal seawater

arsenic exposure increased the concentrations of branched-chain amino acids

and of threonine

proline

phosphocholine and adenosine

and it decreased the levels of alanine

hypotaurine

glucose

glycogen and ATP in the digestive glands. Differential changes in metabolic biomarkers observed at lower salinity (∼23.3) included elevation of succinate

taurine and ATP

and depletion of branched-chain amino acids

threonine and glutamine. Unique effects of arsenic at the lowest salinity (∼15.6) included down-regulation of glutamate

succinate and ADP

and up-regulation of phosphocholine. We conclude that salinity influences the metabolic responses of this clam to arsenic.

关键词

Keywords

references

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