Chemical constituents of marine mangrove-derived endophytic fungus Alternaria tenuissima EN-192

Hong Sun; Shushan Gao; Xiaoming Li; Chunshun Li; Bingui Wang

doi:10.1007/s00343-013-2106-2

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Chemical constituents of marine mangrove-derived endophytic fungus Alternaria tenuissima EN-192

Updated：2023-05-16

- Chemical constituents of marine mangrove-derived endophytic fungus Alternaria tenuissima EN-192
- Journal of Oceanology and Limnology Vol. 31, Issue 2, Pages: 464-470(2013)
- Affiliations：
  
  1. Key Laboratory of Experimental Marine Biology Institute of Oceanology Chinese Academy of Sciences
  2. Graduate University of Chinese Academy of Sciences
- Author bio：
- Funds：
- DOI：10.1007/s00343-013-2106-2
  CLC：
- Online First：07 March 2013，
  
  Published：2013
- Accepted：
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Sun, H., Gao, S., Li, X. et al. Chemical constituents of marine mangrove-derived endophytic fungus Alternaria tenuissima EN-192., Chin. J. Ocean. Limnol. 31, 464–470 (2013). https://doi.org/10.1007/s00343-013-2106-2
DOI：

Sun, H., Gao, S., Li, X. et al. Chemical constituents of marine mangrove-derived endophytic fungus Alternaria tenuissima EN-192., Chin. J. Ocean. Limnol. 31, 464–470 (2013). https://doi.org/10.1007/s00343-013-2106-2 DOI：

摘要

Abstract

A chemical investigation of the ethyl acetate extract of the fermentation broth of Alternaria tenuissima EN-192

an endophytic fungus obtained from the stems of the marine mangrove plant Rhizophora stylosa

resulted in the isolation of nine known secondary metabolites

including four indole-diterpenoids: penijanthine A (1)

paspaline (2)

paspalinine (3)

and penitrem A (4); three tricycloalternarene derivatives: tricycloalternarene 3a (5)

tricycloalternarene 1b (6)

and tricycloalternarene 2b (7); and two alternariol congeners: djalonensone (8) and alternariol (9). The chemical structures of these metabolites were characterized through a combination of detailed spectroscopic analyses and their comparison with reports from the literature. The inhibitory activities of each isolated compound against four bacteria were evaluated and compounds 5 and 8 displayed moderate activity against the aquaculture pathogenic bacterium Vibrio anguillarum

with inhibition zone diameters of 8 and 9 mm

respectively

at 100 μg/disk. To the best of our knowledge

this is the first report on the secondary metabolites of mangrove-derived A lternaria tenuissima and also the first report of the isolation of indole-diterpenoids from fungal genus A lternaria.

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references

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