Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118

Zhuo Shang; Xiaoming Li; Li Meng; Chunshun Li; Shushan Gao; Caiguo Huang; Bingui Wang

doi:10.1007/s00343-012-1075-1

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Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118

Updated：2023-05-16

- Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118
- Journal of Oceanology and Limnology Vol. 30, Issue 2, Pages: 305-314(2012)
- Affiliations：
  
  1. Key Laboratory of Experimental Marine Biology Institute of Oceanology Chinese Academy of Sciences
  2. Graduate University of Chinese Academy of Sciences
  3. Department of Biochemistry and Molecular Biology Second Military Medical University
- Author bio：
- Funds：
- DOI：10.1007/s00343-012-1075-1
  CLC：
- Online First：01 March 2012，
  
  Published：2012
- Accepted：
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Shang, Z., Li, X., Meng, L. et al. Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118., Chin. J. Ocean. Limnol. 30, 305–314 (2012). https://doi.org/10.1007/s00343-012-1075-1
DOI：

Shang, Z., Li, X., Meng, L. et al. Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118., Chin. J. Ocean. Limnol. 30, 305–314 (2012). https://doi.org/10.1007/s00343-012-1075-1 DOI：

摘要

Abstract

Bioassay-guided fractionation of the crude extract from Penicillium commune SD-118

a fungus obtained from a deep-sea sediment sample

resulted in the isolation of a known antibacterial compound

xanthocillin X (1)

and 14 other known compounds comprising three steroids (2–4)

two ceramides (5 and 6)

six aromatic compounds (7–12)

and three alkaloids (13–15). Xanthocillin X (1) was isolated for the first time from a marine fungus. In the bioassay

xanthocillin X (1) displayed remarkable antimicrobial activity against Staphylococcus aureus and Escherichia coli

and significant cytotoxicity against MCF-7

HepG2

H460

Hela

Du145

and MDA-MB-231 cell lines. Meleagrin (15) exhibited cytotoxicity against HepG2

Hela

Du145

and MDA-MB-231 cell lines. This is the first report of the cytotoxicity of xanthocillin X (1).

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references

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