Effects of alga polysaccharide capsule shells on in-vivo bioavailability and disintegration

Ting Li; Shuju Guo; Lin Ma; Yi Yuan; Lijun Han

doi:10.1007/s00343-012-1011-4

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Effects of alga polysaccharide capsule shells on in-vivo bioavailability and disintegration

Updated：2023-05-16

- Effects of alga polysaccharide capsule shells on in-vivo bioavailability and disintegration
- Journal of Oceanology and Limnology Vol. 30, Issue 1, Pages: 22-28(2012)
- Affiliations：
  
  1. Institute of Oceanology Chinese Academy of Sciences
  2. Graduate University of Chinese Academy of Sciences
  3. Pharmacology Lab of the Affiliated Hospital of Medical College Qingdao University
- Author bio：
- Funds：
- DOI：10.1007/s00343-012-1011-4
  CLC：
- Online First：15 November 2012，
  
  Published：2012
- Accepted：
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Li, T., Guo, S., Ma, L. et al. Effects of alga polysaccharide capsule shells on in-vivo bioavailability and disintegration., Chin. J. Ocean. Limnol. 30, 22–28 (2012). https://doi.org/10.1007/s00343-012-1011-4
DOI：

Li, T., Guo, S., Ma, L. et al. Effects of alga polysaccharide capsule shells on in-vivo bioavailability and disintegration., Chin. J. Ocean. Limnol. 30, 22–28 (2012). https://doi.org/10.1007/s00343-012-1011-4 DOI：

摘要

Abstract

Gelatin has been used in hard capsule shells for more than a century

and some shortcomings have appeared

such as high moisture content and risk of transmitting diseases of animal origin to people. Based on available studies regarding gelatin and vegetable shells

we developed a new type of algal polysaccharide capsule (APPC) shells. To test whether our products can replace commercial gelatin shells

we measured in-vivo plasma concentration of 12 selected volunteers with a model drug

ibuprofen

using high performance liquid chromatography (HPLC)

by calculating the relative bioavailability of APPC and Qualicaps® referenced to gelatin capsules and assessing bioequivalence of the three types of shells

and calculated pharmacokinetic parameters with the software DAS 2.0 (China). The results show that APPC shells possess bioequivalence with Qualicaps® and gelatin shells. Moreover

the disintegration behavior of four types of shells (APPC

Vegcaps®

Qualicaps® and gelatin shells) with the content of lactose and radioactive element (99mTc) was observed via gamma-scintigraphic images. The bioavailability and gamma-scintigraphic studies showed that APPC was not statistically different from other vegetable and gelatin capsule shells with respect to in-vivo behavior. Hence

it can be concluded that APPCs are exchangeable with other vegetable and gelatin shells.

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references

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