Transcriptional changes in epigenetic modifiers associated with gene silencing in the intestine of the sea cucumber, Apostichopus japonicus (Selenka), during aestivation

Tianming Wang; Hongsheng Yang; Huan Zhao; Muyan Chen; Bing Wang

doi:10.1007/s00343-011-0143-2

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Transcriptional changes in epigenetic modifiers associated with gene silencing in the intestine of the sea cucumber, Apostichopus japonicus (Selenka), during aestivation

Updated：2023-05-16

- Transcriptional changes in epigenetic modifiers associated with gene silencing in the intestine of the sea cucumber, Apostichopus japonicus (Selenka), during aestivation
- Journal of Oceanology and Limnology Vol. 29, Issue 6, Pages: 1267-1274(2011)
- Affiliations：
  
  1. Institute of Oceanology Chinese Academy of Sciences
  2. Graduate University of Chinese Academy of Sciences
- Author bio：
- Funds：
- DOI：10.1007/s00343-011-0143-2
  CLC：
- Online First：25 October 2011，
  
  Published：2011
- Accepted：
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Wang, T., Yang, H., Zhao, H. et al. Transcriptional changes in epigenetic modifiers associated with gene silencing in the intestine of the sea cucumber, Apostichopus japonicus (Selenka), during aestivation., Chin. J. Ocean. Limnol. 29, 1267–1274 (2011). https://doi.org/10.1007/s00343-011-0143-2
DOI：

Wang, T., Yang, H., Zhao, H. et al. Transcriptional changes in epigenetic modifiers associated with gene silencing in the intestine of the sea cucumber, Apostichopus japonicus (Selenka), during aestivation., Chin. J. Ocean. Limnol. 29, 1267–1274 (2011). https://doi.org/10.1007/s00343-011-0143-2 DOI：

摘要

Abstract

The sea cucumber

Apostichopus japonicus

undergoes aestivation to improve survival during periods of high-temperature. During aestivation

the metabolic rate is depressed to reduce the consumption of reserved energy. We evaluated the role of epigenetic modification on global gene silencing during metabolic rate depression in the sea cucumber. We compared the expression of epigenetic modifiers in active and aestivating sea cucumbers. The expression of three genes involved in DNA methylation and chromatin remodeling (DNA (cytosine-5)-methyltransferase 1

Methyl-CpG-binding domain protein 2)

and Chromodomain-helicase-DNA-binding protein 5) was significantly higher during aestivation (Days 20 and 40). Similarly

we observed an increase in the expression of genes involved in histone acetylation (Histone deacetylase 3) and Histone-binding protein RBBP4) during the early (Days 5 and 10) and late phases (Days 20 and 40) of aestivation. There was no change in the expression of KAT2B

a histone acetyltransferase. However

the expression of histone methylation associated modifiers (Histone-arginine methyltransferase CARMER and Histone-lysine N-methyltransferase MLL5) was significantly higher after 5 d in the aestivating group. The results suggest that the expression of epigenetic modifiers involved in DNA methylation

chromatin remodeling

histone acetylation

and histone methylation is upregulated during aestivation. We hypothesize that these changes regulate global gene silencing during aestivation in A. japonicus.

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references

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