Genes of the adaptive immune system are expressed early in zebrafish larval development following lipopolysaccharide stimulation

Fengling Li; Shicui Zhang; Zhiping Wang; Hongyan Li

doi:10.1007/s00343-011-0077-8

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Genes of the adaptive immune system are expressed early in zebrafish larval development following lipopolysaccharide stimulation

Updated：2023-05-16

- Genes of the adaptive immune system are expressed early in zebrafish larval development following lipopolysaccharide stimulation
- Journal of Oceanology and Limnology Vol. 29, Issue 2, Pages: 326-333(2011)
- Affiliations：
  
  Department of Marine Biology and Laboratory for Evolution and Development Ocean University of China
- Author bio：
- Funds：
- DOI：10.1007/s00343-011-0077-8
  CLC：
- Online First：02 March 2011，
  
  Published：2011
- Accepted：
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Li, F., Zhang, S., Wang, Z. et al. Genes of the adaptive immune system are expressed early in zebrafish larval development following lipopolysaccharide stimulation., Chin. J. Ocean. Limnol. 29, 326–333 (2011). https://doi.org/10.1007/s00343-011-0077-8
DOI：

Li, F., Zhang, S., Wang, Z. et al. Genes of the adaptive immune system are expressed early in zebrafish larval development following lipopolysaccharide stimulation., Chin. J. Ocean. Limnol. 29, 326–333 (2011). https://doi.org/10.1007/s00343-011-0077-8 DOI：

摘要

Abstract

Information regarding immunocompetence of the adaptive immune system (AIS) in zebrafish Danio rerio remains limited. Here

we stimulated an immune response in fish embryos

larvae and adults using lipopolysaccharide (LPS) and measured the upregulation of a number of AIS-related genes (Rag2

AID

TCRAC

IgLC-1

mIg

sIg

IgZ and DAB) 3 and 18 h later. We found that all of the genes evaluated were strongly induced following LPS stimulation

with most of them responding at 8 d post fertilization. This confirms that a functional adaptive immune response is present in D. rerio larvae

and provides a window for further functional analyses.

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references

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