Effect of cyanobacteria extract on some associated enzymes in mouse liver in vivo

Jianzhong Chen; Zhili Liu; Guoqing Zhou; Zhiping Han; Haiyang Zhang; Yixiang Zhang

doi:10.1007/s00343-010-9911-7

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Effect of cyanobacteria extract on some associated enzymes in mouse liver in vivo

Updated：2023-05-16

- Effect of cyanobacteria extract on some associated enzymes in mouse liver in vivo
- Journal of Oceanology and Limnology Vol. 28, Issue 6, Pages: 1180-1186(2010)
- Affiliations：
  
  1. School of Life Science Huzhou Teachers College
  2. School of Life Science Nanjing University
- Author bio：
- Funds：
- DOI：10.1007/s00343-010-9911-7
  CLC：
- Online First：10 November 2010，
  
  Published：2010
- Accepted：
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Chen, J., Liu, Z., Zhou, G. et al. Effect of cyanobacteria extract on some associated enzymes in mouse liver in vivo, ., Chin. J. Ocean. Limnol. 28, 1180–1186 (2010). https://doi.org/10.1007/s00343-010-9911-7
DOI：

Chen, J., Liu, Z., Zhou, G. et al. Effect of cyanobacteria extract on some associated enzymes in mouse liver in vivo, ., Chin. J. Ocean. Limnol. 28, 1180–1186 (2010). https://doi.org/10.1007/s00343-010-9911-7 DOI：

摘要

Abstract

Blooms of toxin-producing cyanobacteria have become increasingly common in the surface water of the world. In this study

we studied the dose- and time-dependent effects of a microcystin (MC) extract of cyanobacteria from Dianchi Lake in China on liver weight/body weight ratio and superoxide dismutase (SOD)

lactate dehydrogenase (LDH) and glutathione peroxidase (GSH-Px) activities in mouse liver. We found that exposure to the cyanobacterial extract (CE) resulted in increase in liver weight/body weight ratio in a dose-dependent manner

and the mouse liver reached the maximum size at 1 h post-exposure (pe). SOD activity in mouse liver decreased in a dose-dependent manner

and time course study indicated that it decreased significantly at 1 and 2 h pe

and resumed at 3 h pe as compared to control. CE caused LDH activity in the livers of mice to decrease in a dose- and time-dependent manner except a small increase in 30 min pe mice. GSH-Px activity increased in a dose-dependent manner

and was higher than that in the control over the 3 h observation period. The present findings suggest that oxidative damage may be involved in the toxicity of microcystins on mouse.

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references

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