Characterization of DYRK2 (dual-specificity tyrosine-phosphorylation-regulated kinase 2) from Zebrafish (Dario rerio)

Wei Sun; Xungang Tan; Peijun Zhang; Yuqing Zhang; Yongli Xu

doi:10.1007/s00343-010-9073-7

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Characterization of DYRK2 (dual-specificity tyrosine-phosphorylation-regulated kinase 2) from Zebrafish (Dario rerio)

Updated：2023-05-16

- Characterization of DYRK2 (dual-specificity tyrosine-phosphorylation-regulated kinase 2) from Zebrafish (Dario rerio)
- Journal of Oceanology and Limnology Vol. 28, Issue 4, Pages: 720-724(2010)
- Affiliations：
  
  1. Institute of Oceanology Chinese Academy of Sciences
  2. Graduate School Chinese Academy of Sciences
- Author bio：
- Funds：
- DOI：10.1007/s00343-010-9073-7
  CLC：
- Online First：29 June 2010，
  
  Published：2010
- Accepted：
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Sun, W., Tan, X., Zhang, P. et al. Characterization of DYRK2 (dual-specificity tyrosine-phosphorylation-regulated kinase 2) from Zebrafish (Dario rerio)., Chin. J. Ocean. Limnol. 28, 720–724 (2010). https://doi.org/10.1007/s00343-010-9073-7
DOI：

Sun, W., Tan, X., Zhang, P. et al. Characterization of DYRK2 (dual-specificity tyrosine-phosphorylation-regulated kinase 2) from Zebrafish (Dario rerio)., Chin. J. Ocean. Limnol. 28, 720–724 (2010). https://doi.org/10.1007/s00343-010-9073-7 DOI：

摘要

Abstract

Proteins of the DYRK (dual-specificity tyrosine-phosphorylation-regulated kinase) family are characterized by the presence of a conserved kinase domain and N-terminal DH box. DYRK2 is involved in regulating key developmental and cellular processes

such as neurogenesis

cell proliferation

cytokinesis

and cellular differentiation. Herein

we report that the ortholog of DYRK2 found in zebrafish shares about 70% identity with that of human

mouse

and chick. RT-PCR showed that DYRK2 is expressed maternally and zygotically. In-situ hybridization results show that DYRK2 is expressed in somite cells that will develop into muscles. Our results provide preliminary evidence for investigating the in-vivo function of DYRK2 in zebrafish muscle development.

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references

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