Immunosuppressive activities of fucoidan fromLaminaria japonica

Zhang Quanbin; Li Zhien; Zhou Gefei; Niu Xizhen; Zhang Hong

doi:10.1007/BF02860427

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Immunosuppressive activities of fucoidan fromLaminaria japonica

Updated：2023-05-16

- Immunosuppressive activities of fucoidan fromLaminaria japonica
- Journal of Oceanology and Limnology Vol. 21, Issue 4, Pages: 324-328(2003)
- Affiliations：
  
  1. Institute of Oceanology Chinese Academy of Sciences
  2. The Graduate School of Chinese Academy of Sciences
- Author bio：
- Funds：
- DOI：10.1007/BF02860427
  CLC：
- Online First：31 January 2013，
  
  Published：2003
- Accepted：
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Quanbin, Z., Zhien, L., Gefei, Z. et al. Immunosuppressive activities of fucoidan fromLaminaria japonica, ., Chin. J. Ocean. Limnol. 21, 324–328 (2003). https://doi.org/10.1007/BF02860427
DOI：

Quanbin, Z., Zhien, L., Gefei, Z. et al. Immunosuppressive activities of fucoidan fromLaminaria japonica, ., Chin. J. Ocean. Limnol. 21, 324–328 (2003). https://doi.org/10.1007/BF02860427 DOI：

摘要

Abstract

Effects of fucoidan fromLaminaria japonica on 2

4-dinitrochlorobenzene induced delayed-type hypersensitivity (DTH) reaction and the serum levels of IgG

IgM

complement C3 and C4 were investigated in the present study. Results showed that oral administration of fucoidan at dose of 150 and 300 mg/(kg· d) for 9 days before the hapten challenge significantly inhibited 2

4-dinitrochlorobenzene induced delayed-type hypersensitivity reaction; and also inhibited the humoral immunity. Serum C3 and C4 levels were markedly reduced by fucoidan at dose of 150 and 300 mg/kg; and serum IgG and IgM levels were reduced by fucoidan at dose of 300mg/kg. The inhibitory effects of fucoidan on delayed-type hypersensitivity suggested that it may be potential medication for chronic inflammatory diseases in the future.

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Keywords

references

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CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences

College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology

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