Protective effect of topically applied polypeptide fromChlamys farreri against ultraviolet radiation-induced chronic skin damage in guinea pig

Chi Mingliang; Cao Pengli; Yu Guoying; Zhu Li; Wang Yuejun; Wang Chunbo

doi:10.1007/BF02860426

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Protective effect of topically applied polypeptide fromChlamys farreri against ultraviolet radiation-induced chronic skin damage in guinea pig

Updated：2023-05-16

- Protective effect of topically applied polypeptide fromChlamys farreri against ultraviolet radiation-induced chronic skin damage in guinea pig
- Journal of Oceanology and Limnology Vol. 21, Issue 4, Pages: 319-323(2003)
- Affiliations：
  
  Medical College Qingdao University
- Author bio：
- Funds：
- DOI：10.1007/BF02860426
  CLC：
- Online First：31 January 2013，
  
  Published：2003
- Accepted：
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Mingliang, C., Pengli, C., Guoying, Y. et al. Protective effect of topically applied polypeptide fromChlamys farreri against ultraviolet radiation-induced chronic skin damage in guinea pig., Chin. J. Ocean. Limnol. 21, 319–323 (2003). https://doi.org/10.1007/BF02860426
DOI：

Mingliang, C., Pengli, C., Guoying, Y. et al. Protective effect of topically applied polypeptide fromChlamys farreri against ultraviolet radiation-induced chronic skin damage in guinea pig., Chin. J. Ocean. Limnol. 21, 319–323 (2003). https://doi.org/10.1007/BF02860426 DOI：

摘要

Abstract

Polypeptide fromChlamys farreri (PCF)

a topical polypeptide isolated fromChlamys farreri

was used in this experiment aimed to investigate the photoprotective effect of PCF against chronic skin damage induced by ultraviolet A (UVA) and ultraviolet B (UVB) radiation. The chronic ultraviolet-irradiated guinea pig model was established

and visible changes in the skin including wrinkling

sagging and erythema were observed. Malondialdehyde (MDA) and antioxidant enzymes including superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) in the dorsal skin were determined using biochemical methods. The results showed: (1) PCF (5 % and 20%) could greatly protect the dorsal skin of guinea pig against wrinkling

sagging and erythema induced by UV radiation in a concentration-dependent manner. (2) PCF could reduce MDA formation in the dorsal skin caused by UV irradiation

while increasing the activities of SOD and GSH-px. (3) The differences among the PCF groups and UV model group were significant (P<0.05

P<0.01). These results indicated that topical application

of PCF provided broad solar UV spectrum photoprotection; and that the antioxidant property of PCF might play a role in photoprotection.

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references

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Related Institution

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