Effect of fossil diatoms on the growth of two syngeneic murine leukemias

Oscar D. Bustuoabad; Alejandro M. S. Mayer

doi:10.1007/BF02851487

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Effect of fossil diatoms on the growth of two syngeneic murine leukemias

Updated：2023-05-16

- Effect of fossil diatoms on the growth of two syngeneic murine leukemias
- Journal of Oceanology and Limnology Vol. 2, Issue 2, Pages: 161-167(1984)
- Affiliations：
  
  Plex-Conicet Instituto de Investigaciones Hematológicas Academia Nacional de Medicina
- Author bio：
- Funds：
- DOI：10.1007/BF02851487
  CLC：
- Published：1984
- Accepted：
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Bustuoabad, O.D., Mayer, A.M.S. Effect of fossil diatoms on the growth of two syngeneic murine leukemias., Chin. J. Ocean. Limnol. 2, 161–167 (1984). https://doi.org/10.1007/BF02851487
DOI：

Bustuoabad, O.D., Mayer, A.M.S. Effect of fossil diatoms on the growth of two syngeneic murine leukemias., Chin. J. Ocean. Limnol. 2, 161–167 (1984). https://doi.org/10.1007/BF02851487 DOI：

摘要

Abstract

The effect of micronized frustules of fossil diatoms (DS) on tumor growth and survival of mice receiving an ip inoculations of either a spontaneous lymphoblastic leukemia (LB) or P-388 lymphocytic leukemia (P-388) was investigated. A multi-dose study was designed

mice receiving 1000

100

10 and 1 μg of a suspension of DS

either ip or sc on day 1

4 and 9 after tumor inoculation. With LB the best results were observed when DS were inoculated by the ip route

no effect being observed with the sc route. The best therapeutic effect resulted with 1 μg DS: 33% of the mice were alive 24 days after tumor inoculation

when all the controls had died. With P-388

only a temporary effect with the 10 μg DS dose was observed. In no case was it possible to prolong survival. It is concluded that at low doses of DS therapeutic effect is greatest

while toxicity due to SiO2 is greatly reduced.

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references

Bustuoabad, O. D., J. A. Genovese and C. D. Pasqualini, 1981. Efecto de partículas de diatomeas sobre el desarrollo de una leucemia singeneica en el ratón.Medicina (Bs Aires)41: 215–220.

Geran, R. I., N. H. Greenberg, M. M. Macdonald, A. M. Schumacher and B. J. Abbott, 1972. Protocols for screening chemical agents and natural products against animal tumors and other biological system (Third Edition). Cancer Chemotherapy Report3: 1–103.

Keller, R., 1973. Cytostatic elimination of syngeneic rat tumor cells in vitro by non specifically activated macrophages.J. Exp. Med. 138: 625–644.

Keller, R., 1976. Promotion of tumor growth in vivo by antimacrophage agents.J. Natl. Cancer Institute 57: 1355–1361.

McGuire, R. L. and R. A. Fox, 1979. Suppression of delayed hypersensitivity by the depletion of circulating monocytes.Immunol. 38: 157–161.

Phillips, H. J., 1972.In: Dye exclusion tests for cell viability. Academic Press, Beijing, pp. 406.

Tsuruo, T., H. Iida, S. Tsukagoshi and Y. Sakurai, 1981. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.Cancer Res. 41: 1967–1972.

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