Antitumor and immune regulation activities of the extracts of some Chinese marine invertebrates

Zhang Lixin; Fan Xiao; Han Lijun

doi:10.1007/BF02845151

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Antitumor and immune regulation activities of the extracts of some Chinese marine invertebrates

Updated：2023-05-16

- Antitumor and immune regulation activities of the extracts of some Chinese marine invertebrates
- Journal of Oceanology and Limnology Vol. 23, Issue 1, Pages: 110-117(2005)
- Affiliations：
  
  1. Institute of Oceanology Chinese Academy of Sciences
  2. College of Chemistry Engineering Qingdao University
  3. Graduated School of the Chinese Academy of Sciences
- Author bio：
- Funds：
- DOI：10.1007/BF02845151
  CLC：
- Published：2005
- Accepted：
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Lixin, Z., Xiao, F. & Lijun, H. Antitumor and immune regulation activities of the extracts of some Chinese marine invertebrates., Chin. J. Ocean. Limnol. 23, 110–117 (2005). https://doi.org/10.1007/BF02845151
DOI：

Lixin, Z., Xiao, F. & Lijun, H. Antitumor and immune regulation activities of the extracts of some Chinese marine invertebrates., Chin. J. Ocean. Limnol. 23, 110–117 (2005). https://doi.org/10.1007/BF02845151 DOI：

摘要

Abstract

Extracts of 21 marine invertebrates belonging to Coelenterata

Mollusca

Annelida

Bryozoa

Echiura

Arthropoda

Echinodermata and Urochordata were screened for the studies on their antitumor and immune regulation activities. Antitumor activity was determined by MTT method and immune regulation activity was studied using T- and B-lymphocytes in mice spleenin vitro. It was found that the n-butanol part ofAsterina pectinifera

the acetic ether part ofTubuaria marina

95% ethanol extract ofAcanthochiton rubrolineatus have a high inhibition rate of 96.7%

63.9% and 50.5% respectively on tumor cell line HL-60 at the concentration of 0.063 mg/ml. The inhibition rate of the acetic ether part ofTubuaria marina on the tumor cell line A-549 is 65.4% at concentration of 0.063 mg/mL. The 95% ethanol extract ofMeretrix meretrix has so outstanding promoting effect on T-lymphocytes that their multiplication increases 25% when the sample concentration is only 1 μg/ml. On B-lymphocytes

the 95% extract ofRapana venosa

at concentration of 100 μg/ml

has a promotion percentage of 60%. On the other hand

under the condition of no cytotoxic effect

the 95% ethanol extracts ofAcanthochiton rubrolineatus andCellana toreum can reach 92% inhibition rate on T lymphocyte at concentration of 100 μg/ml

while the inhibition rate on B lymphocyte of the 95% extract ofAcanthochiton rubrolineatus reaches 92% at the same concentration.

关键词

Keywords

references

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