Studies on the antitumor activity and isolation of the glycoprotein from the gonad ofChlamys (Azumapecten) farreri

Gu Qian-qun; Fang Yu-chun; Wang Chang-yun; Xiao Hang; Qin Yu-qing

doi:10.1007/BF02844933

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Studies on the antitumor activity and isolation of the glycoprotein from the gonad ofChlamys (Azumapecten) farreri

Updated：2023-05-16

- Studies on the antitumor activity and isolation of the glycoprotein from the gonad ofChlamys (Azumapecten) farreri
- Journal of Oceanology and Limnology Vol. 16, Issue 4, Pages: 359-363(1998)
- Affiliations：
  
  Institute of Marine Drugs and Foods
- Author bio：
- Funds：
- DOI：10.1007/BF02844933
  CLC：
- Published：1998
- Accepted：
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Qian-qun, G., Yu-chun, F., Chang-yun, W. et al. Studies on the antitumor activity and isolation of the glycoprotein from the gonad ofChlamys (Azumapecten) farreri, ., Chin. J. Ocean. Limnol. 16, 359–363 (1998). https://doi.org/10.1007/BF02844933
DOI：

Qian-qun, G., Yu-chun, F., Chang-yun, W. et al. Studies on the antitumor activity and isolation of the glycoprotein from the gonad ofChlamys (Azumapecten) farreri, ., Chin. J. Ocean. Limnol. 16, 359–363 (1998). https://doi.org/10.1007/BF02844933 DOI：

摘要

Abstract

After being degreased with acetone

the female gonad ofChlamys (Azumapecten) farreri was extracted with water

and then subjected to DEAE—cellulose column chromatography and purified by Sephadex G-100 chromatography to obtain a pure female gonad glycoprotein (FGGP). The IR spectra

electrophoresis and chemical analysis of FGGP indicated that it was a kind of acid glycoprotein and that the content of total protein and sugar were 54.8% and 40%

respectively. Pharmacological tests showed that FGGP could inhibit (inhibition rate of 40.87%) the growth of Sarcoma 180 of mice.

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references

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Gu Qianqun, 1996. Preliminary studies on the antitumor activity of glycoprotein fromChlamys (Azumapecten) farreri. 1st National Symposium on Marine Bioactive Substances and Natural Medicines. p. 502–504. (in Chinese, with English abstract)

Huang Weikun, 1991. Analysis and Inspection of Food. Shanghai Science Press, Shanghai, p. 66–68.

Kamiya H., Muramoto K., 1988. Studies on bioactive marine metabolites-VII characterization of the antibacterial and antineoplastic glycoprotein in a sea hareAplysia juliana.Nippon Susan Gakkaishi 54(5):737–777.

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Related Institution

Key Lab of Sustainable Development of Marine Fisheries, Ministry of Agriculture; Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences

Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology

Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences

University of Chinese Academy of Sciences

Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology

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