In vitro study on cytotoxic effects of the organopho-sphorous pesticide profenofos on the gill cell line, FG-9307, of the flounder (Paralichihys olivaceus)

Li Hong-yan; Zhang Shi-cui; Jiang Ming; Wang Min

doi:10.1007/BF02842790

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In vitro study on cytotoxic effects of the organopho-sphorous pesticide profenofos on the gill cell line, FG-9307, of the flounder (Paralichihys olivaceus)

Updated：2023-05-16

- In vitro study on cytotoxic effects of the organopho-sphorous pesticide profenofos on the gill cell line, FG-9307, of the flounder (Paralichihys olivaceus)
- Journal of Oceanology and Limnology Vol. 19, Issue 1, Pages: 57-62(2001)
- Affiliations：
  
  Department of Marine Biology Ocean University of Qingdao
- Author bio：
- Funds：
- DOI：10.1007/BF02842790
  CLC：
- Published：2001
- Accepted：
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Hong-yan, L., Shi-cui, Z., Ming, J. et al. , In vitro study on cytotoxic effects of the organopho-sphorous pesticide profenofos on the gill cell line, FG-9307, of the flounder (Paralichihys olivaceus)., Chin. J. Ocean. Limnol. 19, 57–62 (2001). https://doi.org/10.1007/BF02842790
DOI：

Hong-yan, L., Shi-cui, Z., Ming, J. et al. , In vitro study on cytotoxic effects of the organopho-sphorous pesticide profenofos on the gill cell line, FG-9307, of the flounder (Paralichihys olivaceus)., Chin. J. Ocean. Limnol. 19, 57–62 (2001). https://doi.org/10.1007/BF02842790 DOI：

摘要

Abstract

The FG-9007 cell line derived from the gill of flounderParalichthys olivaceus was used in the present study to determine the acute cytotoxic effects of the organophosphorous pesticide

profenofos. It was found that the cell growth rate was markedly reduced by profenofos at the concentrations of 2.5

5 and 7.5 mg/L tested; and that the fine structures of the cells were also altered by profenofos

as evidenced by dilation of nuclear membranes and mitochondria cristae

and presence of enlarged lysosomes with engulfed organelles and numerous vacuoles in the cytoplasm. Probably

mitochondria

the cell energy-generating sites

are the most prominent sites of profenofos cytotoxity in the cells. This seems to be the first report of the use of marine fish cell line for evaluation of the acute in vitro cytotoxicity of organophosphorus pesticide.

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references

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