The genotoxic effects of benzo[a]pyrene and methamidophos on black porgy evaluated by comet assay

Liu Rixian; Hong Huasheng; Wang Xinhong; Wang Kejian; Wang Chunguang

doi:10.1007/BF02842691

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The genotoxic effects of benzo[a]pyrene and methamidophos on black porgy evaluated by comet assay

Updated：2023-05-16

- The genotoxic effects of benzo[a]pyrene and methamidophos on black porgy evaluated by comet assay
- Journal of Oceanology and Limnology Vol. 23, Issue 4, Pages: 455-460(2005)
- Affiliations：
  
  State Key Laboratory for Marine Environmental Science Environmental Science Research Center Xiamen University
- Author bio：
- Funds：
- DOI：10.1007/BF02842691
  CLC：
- Published：2005
- Accepted：
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Rixian, L., Huasheng, H., Xinhong, W. et al. The genotoxic effects of benzo[a]pyrene and methamidophos on black porgy evaluated by comet assay., Chin. J. Ocean. Limnol. 23, 455–460 (2005). https://doi.org/10.1007/BF02842691
DOI：

Rixian, L., Huasheng, H., Xinhong, W. et al. The genotoxic effects of benzo[a]pyrene and methamidophos on black porgy evaluated by comet assay., Chin. J. Ocean. Limnol. 23, 455–460 (2005). https://doi.org/10.1007/BF02842691 DOI：

摘要

Abstract

In this study

two common pollutants (benzo[a]pyrene and methamidophos) in marine environment were tested by comet assay for their inducement ofin vivo genotoxic effect to the blood cells of black porgy (Acanthopagrus schlegeli). The fish was exposed to 2 μg/L of benzo[a]pyrene (BaP) and methamidophos

and their mixture. The assay was performed on whole blood at 2 h

5 h

24 h and 96 h exposure intervals. A significant increase in DNA damage was observed in each treatment with the pollutants. Additive effect of BaP and methamidophos was also found in the experiment. However

the decrease ratios of DNA damage for 5 h and 96 h exposure interals compared with 2 h and 24 h exposure ones

respectively

were noticed. This phenomenon may be explained by the function of repairing process via enzyme cytochrome P450 in the animal. Evidence of the genotoxicity of organophosphorus pesticides (OPs) and polynuclear aromatic hydrocarbons (PAHs) on marine fish are discussed in this paper.

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references

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