The toxic impacts of microplastics-borne benzo[a]pyrene and heavy metals on the health and behavior of seahorse <italic style="font-style: italic">Hippocampus</italic> <italic style="font-style: italic">erectus</italic>

Ying LIU; Nan LI; Dongwei SHANG; Yanjing YANG; Pei CUI; Jinhui SUN

doi:10.1007/s00343-024-3249-z

Your Location：

Home >

Browse articles >

The toxic impacts of microplastics-borne benzo[a]pyrene and heavy metals on the health and behavior of seahorse Hippocampus erectus

Ecotoxicological implications for micro- and nano-plastics | Updated：2025-03-21

- The toxic impacts of microplastics-borne benzo[a]pyrene and heavy metals on the health and behavior of seahorse Hippocampus erectus
- The toxic impacts of microplastics-borne benzo[a]pyrene and heavy metals on the health and behavior of seahorse Hippocampus erectus
- 海洋湖沼学报(英文) 2025年43卷第2期页码：559-571
- Affiliations：
  
  1.Tianjin Key Laboratory of Green Ecological Feed, Tianjin Agricultural University, Tianjin 300384, China
  2.Tianjin Fisheries Research Institute, Tianjin 300000, China
  3.Tianjin Nongken Bohai Agricultural Group Co., Ltd., Tianjin 301809, China
- Author bio：
  
  jhsun1008@163.com
- Funds：
  
  the Marine Economic Development Project(GDNRC[2022]36);the National Key Research and Development Program of China(2018YFD0900206);the Tianjin Science and Technology Program Project(21YDTPJC00340)
- DOI：10.1007/s00343-024-3249-z
  中图分类号：
- 收稿：2023-11-20，
  
  网络首发：2024-01-04，
  
  纸质出版：2025-03-01
- Accepted：
Scan QR Code
The toxic impacts of microplastics-borne benzo[a]pyrene and heavy metals on the health and behavior of seahorse Hippocampus erectus[J]. 海洋湖沼学报(英文), 2025,43(2):559-571.

LIU Ying,LI Nan,SHANG Dongwei,et al.The toxic impacts of microplastics-borne benzo[a]pyrene and heavy metals on the health and behavior of seahorse Hippocampus erectus[J].Journal of Oceanology and Limnology,2025,43(02):559-571.
The toxic impacts of microplastics-borne benzo[a]pyrene and heavy metals on the health and behavior of seahorse Hippocampus erectus[J]. 海洋湖沼学报(英文), 2025,43(2):559-571. DOI： 10.1007/s00343-024-3249-z.

LIU Ying,LI Nan,SHANG Dongwei,et al.The toxic impacts of microplastics-borne benzo[a]pyrene and heavy metals on the health and behavior of seahorse Hippocampus erectus[J].Journal of Oceanology and Limnology,2025,43(02):559-571. DOI： 10.1007/s00343-024-3249-z.

摘要

Abstract

Marine pollution poses a critical threat to biodiversity. The synergistic effects of microplastics

specifically high-density polyethylene (HDPE)

combined with benzo[a

]

pyrene (B[a

]

P) and heavy metals

on the physiology and feeding behavior of the seahorse

Hippocampus

erectus

were studied. The growth parameters

pollutant bioaccumulation

enzymatic response

and feeding dynamics were extensively analyzed. Seahorses exposed to microplastics-borne B[a

]

P and heavy metals exhibited notable reductions in body length and weight

as well as in survival rates

indicating severe stress from these contaminants. The accumulation of pollutant particularly B[a

]

P in seahorse exceeded China’s national regulatory limit of 5 μg/kg

and the B[a

]

P accumulation in seahorses was obviously aided by HDPE microplastics

posing a risk to marine organisms and human health via the food chain. The adaptive response of the seahorses was evident shown in the elevation of antioxidant enzyme activities

which is a biological mechanism to mitigate oxidative stress induced by the pollutants. However

this physiological adaptation comes at a cost

as ev

idenced by marked changes in the feeding behavior. Results show that the efficiency and frequency of feeding were greatly reduced

indicating a heavy impact on the ecological role and survival of this marine creature in polluted habitats. This research offers a crucial perspective on the compound threats of microplastics and associated pollutants in marine ecosystems. It highlights the urgent need develop comprehensive strategies to address these environmental issues. The findings are an important contribution to ecotoxicology

providing a deeper understanding of how microplastics act as vectors for other contaminants and their profound effects on marine life

especially species like seahorses. This study calls for action to strengthen environmental policies and practices aimed at mitigating the impact of marine pollution.

关键词

Keywords

references

Ali H , Khan E , Ilahi I . 2019 . Environmental chemistry and ecotoxicology of hazardous heavy metals: environmental persistence, toxicity, and bioaccumulation . Journal of Chemistry , 2019 : 6730305 , https://doi.org/10.1155/2019/6730305 https://doi.org/10.1155/2019/6730305 .

Amélineau F , Bonnet D , Heitz O et al . 2016 . Microplastic pollution in the Greenland Sea: background levels and selective contamination of planktivorous diving seabirds . Environmental Pollution , 219 : 1131 - 1139 , https://doi.org/10.1016/j.envpol.2016.09.017 https://doi.org/10.1016/j.envpol.2016.09.017 .

Arif I , Shang Y Y , Zhang C Q et al . 2022 . Combined effects of nanoplastics and heavy metal on antioxidant parameters of juvenile tri-spine horseshoe crabs . Frontiers in Marine Science , 9 : 1005820 , https://doi.‍org/10.3389/fmars.2022.1005820 https://doi.‍org/10.3389/fmars.2022.1005820 . https://do 10.3389/fmars.2022.1005820 http://dx.doi.org/10.3389/fmars.2022.1005820

Arthur C , Baker J , Bamford H . 2009 . Proceedings of the International Research Workshop on the Occurrence, Effects, and Fate of Microplastic Marine Debris . University of Washington Tacoma , https://repository.library.noaa.gov/view/noaa/2509/noaa_2509_DS1 https://repository.library.noaa.gov/view/noaa/2509/noaa_2509_DS1 .

Bendiksen E Å , Jobling M , Arnesen A M . 2002 . Feed intake of Atlantic salmon parr Salmo salar L. in relation to temperature and feed composition . Aquaculture Research , 33 ( 7 ): 525 - 532 , https://doi.org/10.1046/j.1365-2109.2002.00737.x https://doi.org/10.1046/j.1365-2109.2002.00737.x .

Brennecke D , Ferreira E C , Costa T M M et al . 2015 . Ingested microplastics ( > 100 μm) are translocated to organs of the tropical fiddler crab Uca rapax . Marine Pollution Bulletin , 96 ( 1-2 ): 491 - 495 , https://doi.org/10.1016/j.marpolbul.2015.05.001 https://doi.org/10.1016/j.marpolbul.2015.05.001 .

Chae Y , An Y J . 2017 . Effects of micro- and nanoplastics on aquatic ecosystems: current research trends and perspectives . Marine Pollution Bulletin , 124 ( 2 ): 624 - 632 , https://doi.org/10.1016/j.marpolbul.2017.01.070 https://doi.org/10.1016/j.marpolbul.2017.01.070 .

Chen T , Wong M K H , Chan B C B et al . 2019 . Mechanisms for temperature modulation of feeding in goldfish and implications on seasonal changes in feeding behavior and food intake . Frontiers in Endocrinology , 10 : 133 , https://doi.org/10.3389/fendo.2019.00133 https://doi.org/10.3389/fendo.2019.00133 .

Choi J S , Jung Y J , Hong N H et al . 2018 . Toxicological effects of irregularly shaped and spherical microplastics in a marine teleost, the sheepshead minnow ( Cyprinodon variegatus ) . Marine Pollution Bulletin , 129 ( 1 ): 231 - 240 , https://doi.org/10.1016/j.marpolbul.2018.02.039 https://doi.org/10.1016/j.marpolbul.2018.02.039 .

De Marco G , Conti G O , Giannetto A et al . 2022 . Embryotoxicity of polystyrene microplastics in zebrafish Danio rerio . Environmental Research , 208 : 112552 , https://doi.org/10.1016/j.envres.2021.112552 https://doi.org/10.1016/j.envres.2021.112552 .

Debbarma N , Gurjar U R , Ramteke K K et al . 2022 . Abundance and characteristics of microplastics in gastrointestinal tracts and gills of croaker fish ( Johnius dussumieri ) from off Mumbai coastal waters of India . Marine Pollution Bulletin , 176 : 113473 , https://doi.org/10.1016/j.marpolbul.2022.113473 https://doi.org/10.1016/j.marpolbul.2022.113473 .

Do V M , Dang T T , Le X T T et al . 2022 . Abundance of microplastics in cultured oysters ( Crassostrea gigas ) from Danang Bay of Vietnam . Marine Pollution Bulletin , 180 : 113800 , https://doi.org/10.1016/j.marpolbul.2022.113800 https://doi.org/10.1016/j.marpolbul.2022.113800 .

Domínguez-López M , Bellas J , Sánchez-Ruiloba L et al . 2022 . First evidence of ingestion and retention of microplastics in seahorses ( Hippocampus reidi ) using copepods ( Acartia tonsa ) as transfer vectors . Science of the Total Environment , 818 : 151688 , https://doi.org/10.1016/j.scitotenv.2021.151688 https://doi.org/10.1016/j.scitotenv.2021.151688 .

Folkedal O , Stien L H , Torgersen T et al . 2012 . Food anticipatory behaviour as an indicator of stress response and recovery in Atlantic salmon post-smolt after exposure to acute temperature fluctuation . Physiology & Behavior , 105 ( 2 ): 350 - 356 , https://doi.org/10.1016/j.physbeh.2011.08.008 https://doi.org/10.1016/j.physbeh.2011.08.008 .

Gao Y M , Huang W , Jiang N J et al . 2023 . Combined effects of microfibers and polychlorinated biphenyls on the immune function of hemocytes in the mussel Mytilus coruscus . Marine Environmental Research , 192 : 106214 , https://doi.org/10.1016/j.marenvres.2023.106214 https://doi.org/10.1016/j.marenvres.2023.106214 .

Geng X H , Wang J , Zhang Y et al . 2021 . How do microplastics affect the marine microbial loop? Predation of microplastics by microzooplankton . Science of the Total Environment , 758 : 144030 , https://doi.org/10.1016/j.scitotenv.2020.144030 https://doi.org/10.1016/j.scitotenv.2020.144030 .

Gholizadeh M , Patimar R . 2018 . Ecological risk assessment of heavy metals in surface sediments from the Gorgan Bay, Caspian Sea . Marine Pollution Bulletin , 137 : 662 - 667 , https://doi.org/10.1016/j.marpolbul.2018.11.009 https://doi.org/10.1016/j.marpolbul.2018.11.009 .

Goldberg E D . 1975 . The mussel watch—A first step in global marine monitoring . Marine Pollution Bulletin , 6 ( 7 ): 111 , https://doi.org/10.1016/0025-326X(75)90271-4 https://doi.org/10.1016/0025-326X(75)90271-4 .

Gray A D , Wertz H , Leads R R et al . 2018 . Microplastic in two South Carolina Estuaries: occurrence, distribution, and composition . Marine Pollution Bulletin , 128 : 223 - 233 , https://doi.org/10.1016/j.marpolbul.2018.01.030 https://doi.org/10.1016/j.marpolbul.2018.01.030 .

Groten J P , Feron V J , Sühnel J . 2001 . Toxicology of simple and complex mixtures . Trends in Pharmacological Sciences , 22 ( 6 ): 316 - 322 , https://doi.org/10.1016/S0165-6147(00)01720-X https://doi.org/10.1016/S0165-6147(00)01720-X .

Güven O , Gökdağ K , Jovanović B et al . 2017 . Microplastic litter composition of the Turkish territorial waters of the Mediterranean Sea, and its occurrence in the gastrointestinal tract of fish . Environmental Pollution , 223 : 286 - 294 , https://doi.org/10.1016/j.envpol.2017.01.025 https://doi.org/10.1016/j.envpol.2017.01.025 .

Jambeck J R , Geyer R , Wilcox C et al . 2015 . Plastic waste inputs from land into the ocean . Science , 347 ( 6223 ): 768 - 771 , https://doi.org/10.1126/science.1260352 https://doi.org/10.1126/science.1260352 .

Jiang W W , Fang J H , Du M R et al . 2022 . Microplastics influence physiological processes, growth and reproduction in the Manila clam, Ruditapes philippinarum . Environmental Pollution , 293 : 118502 , https://doi.org/10.1016/j.envpol.2021.118502 https://doi.org/10.1016/j.envpol.2021.118502 .

Jovanović B , Gökdağ K , Güven O et al . 2018 . Virgin microplastics are not causing imminent harm to fish after dietary exposure . Marine Pollution Bulletin , 130 : 123 - 131 , https://doi.org/10.1016/j.marpolbul.2018.03.016 https://doi.org/10.1016/j.marpolbul.2018.03.016 .

Kasumyan A O . 2019 . The taste system in fishes and the effects of environmental variables . Journal of Fish Biology , 95 ( 1 ): 155 - 178 , https://doi.org/10.1111/jfb.13940 https://doi.org/10.1111/jfb.13940 .

Kasumyan A O , Døving K B . 2003 . Taste preferences in fishes . Fish and Fisheries , 4 ( 4 ): 289 - 347 , https://doi.org/10.1046/j.1467-2979.2003.00121.x https://doi.org/10.1046/j.1467-2979.2003.00121.x .

Kiris I G A , Eroldoğan O T , Kır M et al . 2004 . Influence of neuropeptide Y (NPY) on food intake and growth of penaeid shrimps Marsupenaeus japonicus and Penaeus semisulcatus (Decapoda: penaeidae) . Comparative Biochemistry and Physiology Part A : Molecular & Integrative Physiology , 139 ( 2 ): 239 - 244 , https://doi.org/10.1016/j.cbpb.2004.09.008 https://doi.org/10.1016/j.cbpb.2004.09.008 .

Liang W W H , Li B W , Jong M C et al . 2023 . Process-oriented impacts of microplastic fibers on behavior and histology of fish . Journal of Hazardous Materials , 448 : 130856 , https://doi.org/10.1016/j.jhazmat.2023.130856 https://doi.org/10.1016/j.jhazmat.2023.130856 .

Liu S T , Shi J F , Wang J et al . 2021 . Interactions between microplastics and heavy metals in aquatic environments: a review . Frontiers in Microbiology , 12 : 652520 , https://doi.org/10.3389/fmicb.2021.652520 https://doi.org/10.3389/fmicb.2021.652520 .

Lu Y F , Zhang Y , Deng Y F et al . 2016 . Uptake and accumulation of polystyrene microplastics in zebrafish ( Danio rerio ) and toxic effects in liver . Environmental Science & Technology , 50 ( 7 ): 4054 - 4060 , https://doi.‍org/10.1021/acs.est.6b00183 https://doi.‍org/10.1021/acs.est.6b00183 . https://do 10.1021/acs.est.6b00183 http://dx.doi.org/10.1021/acs.est.6b00183

Maria V L , Bebianno M J . 2011 . Antioxidant and lipid peroxidation responses in Mytilus galloprovincialis exposed to mixtures of benzo(a)pyrene and copper . Comparative Biochemistry and Physiology Part C : Toxicology & Pharmacology , 154 ( 1 ): 56 - 63 , https://doi.org/10.1016/j.cbpc.2011.02.004 https://doi.org/10.1016/j.cbpc.2011.02.004 .

Mato Y , Isobe T , Takada H et al . 2001 . Plastic resin pellets as a transport medium for toxic chemicals in the marine environment . Environmental Science & Technology , 35 ( 2 ): 318 - 324 , https://doi.org/10.1021/es0010498 https://doi.org/10.1021/es0010498 .

National Health Commission of the People's Republic of China . 2016 . GB 5009.27-2016 National Food Safety Standard-Determination of Benzo [a ] pyrene in Foods. Food Quality and Safety , 2095 - 0381 , http://www.nhc.gov.cn/ http://www.nhc.gov.cn/ .

Nasser F , Lynch I . 2016 . Secreted protein eco-corona mediates uptake and impacts of polystyrene nanoparticles on Daphnia magna . Journal of Proteomics , 137 : 45 - 51 , https://doi.org/10.1016/j.jprot.2015.09.005 https://doi.org/10.1016/j.jprot.2015.09.005 .

Oliveira M , Ribeiro A , Hylland K et al . 2013 . Single and combined effects of microplastics and pyrene on juveniles (0+ group) of the common goby Pomatoschistus microps (Teleostei, Gobiidae) . Ecological Indicators , 34 : 641 - 647 , https://doi.org/10.1016/j.ecolind.2013.06.019 https://doi.org/10.1016/j.ecolind.2013.06.019 .

Pan L Q , Liu N , Wang J . 2012 . Study of biomarkers selection of the scallop Chlamys farreri exposed to B [a ] P. Acta Hydrobiologica Sinica , 36 ( 2 ): 299 - 306 , https://doi.org/10.3724/SP.J.1035.2012.00299. https://doi.org/10.3724/SP.J.1035.2012.00299. (in Chinese with English abstract)

Pan L Q , Ren J Y , Liu J . 2005 . Effects of benzo(k)fluoranthene exposure on the biomarkers of scallop Chlamys farreri . Comparative Biochemistry and Physiology Part C : Toxicology & Pharmacology , 141 ( 3 ): 248 - 256 , https://doi.org/10.1016/j.cca.2005.07.005 https://doi.org/10.1016/j.cca.2005.07.005 .

Pan X , Sheng X Q , Zhang W X et al . 2022 . Effects of short-term temperature changes on the physiology, biochemistry and feeding behaviour of the juvenile yellow seahorse— Hippopotamus kuda Bleeker . Aquaculture Research , 53 ( 3 ): 1084 - 1097 , https://doi.org/10.1111/are.15649 https://doi.org/10.1111/are.15649 .

Pan Y T , Qian J , Ma X W et al . 2023 . Response of moulting genes and gut microbiome to nano-plastics and copper in juvenile horseshoe crab Tachypleus tridentatus . Marine Environmental Research , 191 : 106128 , https://doi.org/10.1016/j.marenvres.2023.106128 https://doi.org/10.1016/j.marenvres.2023.106128 .

Parker B W , Beckingham B A , Ingram B C et al . 2020 . Microplastic and tire wear particle occurrence in fishes from an urban estuary: influence of feeding characteristics on exposure risk . Marine Pollution Bulletin , 160 : 111539 , https://doi.org/10.1016/j.marpolbul.2020.111539 https://doi.org/10.1016/j.marpolbul.2020.111539 .

Peng L C , Fu D D , Qi H Y et al . 2020 . Micro- and nano-plastics in marine environment: source, distribution and threats‍‍‍——‍A review . Science of the Total Environment , 698 : 134254 , https://doi.org/10.1016/j.scitotenv.2019.134254 https://doi.org/10.1016/j.scitotenv.2019.134254 .

Pittura L , Avio C G , Giuliani M E et al . 2018 . Microplastics as vehicles of environmental PAHs to marine organisms: combined chemical and physical hazards to the Mediterranean mussels, Mytilus galloprovincialis . Frontiers in Marine Science , 5 : 103 , https://doi.org/10.3389/fmars.2018.00103 https://doi.org/10.3389/fmars.2018.00103 .

Prato E , Biandolino F . 2007 . Combined toxicity of mercury, copper and cadmium on embryogenesis and early larval stages of the Mytilus galloprovincialis . Environmental Technology , 28 ( 8 ): 915 - 920 , https://doi.org/10.1080/09593332808618851 https://doi.org/10.1080/09593332808618851 .

Rashid C P , Jyothibabu R , Arunpandi N et al . 2021 . Microplastics in zooplankton in the eastern Arabian Sea: the threats they pose to fish and corals favoured by coastal currents . Marine Pollution Bulletin , 173 : 113042 , https://doi.org/10.1016/j.marpolbul.2021.113042 https://doi.org/10.1016/j.marpolbul.2021.113042 .

Rochman C M , Kurobe T , Flores I et al . 2014 . Early warning signs of endocrine disruption in adult fish from the ingestion of polyethylene with and without sorbed chemical pollutants from the marine environment . Science of the Total Environment , 493 : 656 - 661 , https://doi.‍org/10.1016/j.scitotenv.2014.06.051 https://doi.‍org/10.1016/j.scitotenv.2014.06.051 . https://do 10.1016/j.scitotenv.2014.06.051 http://dx.doi.org/10.1016/j.scitotenv.2014.06.051

Rubio V C , Sánchez-Vázquez F J , Madrid J A . 2005 . Effects of salinity on food intake and macronutrient selection in European sea bass . Physiology & Behavior , 85 ( 3 ): 333 - 339 , https://doi.org/10.1016/j.physbeh.2005.04.022 https://doi.org/10.1016/j.physbeh.2005.04.022 .

Santacroce M P , Pastore A S , Tinelli A et al . 2015 . Implications for chronic toxicity of benzo [a ] pyrene in sea bream cultured hepatocytes: cytotoxicity, inflammation, and cancerogenesis. Environmental Toxicology , 30 ( 9 ): 1045 - 1062 , https://doi.org/10.1002/tox.21978 https://doi.org/10.1002/tox.21978 .

Santos D , Perez M , Perez E et al . 2022 . Toxicity of microplastics and copper, alone or combined, in blackspot seabream ( Pagellus bogaraveo ) larvae . Environmental Toxicology and Pharmacology , 91 : 103835 , https://doi.org/10.1016/j.etap.2022.103835 https://doi.org/10.1016/j.etap.2022.103835 .

Sharma J G , Singh S P , Chakrabarti R . 2017 . Effect of temperature on digestive physiology, immune-modulatory parameters , and expression level of Hsp and LDH genes in Catla catla (Hamilton , 1822 ). Aquaculture, 479 : 134 - 141 , https://doi.org/10.1016/j.aquaculture.2017.05.031 https://doi.org/10.1016/j.aquaculture.2017.05.031 .

Shi W , Sun S G , Han Y et al . 2021 . Microplastics impair olfactory-mediated behaviors of goldfish Carassius auratus . Journal of Hazardous Materials , 409 : 125016 , https://doi.org/10.1016/j.jhazmat.2020.125016 https://doi.org/10.1016/j.jhazmat.2020.125016 .

Shi W , Sun S G , Han Y et al . 2022 . Microplastics hamper the fertilization success of a broadcast spawning bivalve through reducing gamete collision and gamete fusion efficiency . Aquatic Toxicology , 242 : 106049 , https://doi.org/10.1016/j.aquatox.2021.106049 https://doi.org/10.1016/j.aquatox.2021.106049 .

Sun J H , Xia S D , Ning Y et al . 2019 . Effects of microplastics and attached heavy metals on growth, immunity, and heavy metal accumulation in the yellow seahorse, Hippocampus kuda Bleeker . Marine Pollution Bulletin , 149 : 110510 , https://doi.org/10.1016/j.marpolbul.2019.110510 https://doi.org/10.1016/j.marpolbul.2019.110510 .

Sun S G , Shi W , Tang Y et al . 2021 . The toxic impacts of microplastics (MPs) and polycyclic aromatic hydrocarbons (PAHs) on haematic parameters in a marine bivalve species and their potential mechanisms of action . Science of the Total Environment , 783 : 147003 , https://doi.org/10.1016/j.scitotenv.2021.147003 https://doi.org/10.1016/j.scitotenv.2021.147003 .

Sun X X , Liang J H , Zhu M L et al . 2018 . Microplastics in seawater and zooplankton from the Yellow Sea . Environmental Pollution , 242 : 585 - 595 , https://doi.‍org/10.1016/j.envpol.2018.07.014 https://doi.‍org/10.1016/j.envpol.2018.07.014 . https://do 10.1016/j.envpol.2018.07.014 http://dx.doi.org/10.1016/j.envpol.2018.07.014

Tang L , Liu Y L , Qin G et al . 2021 . Effects of tributyltin on gonad and brood pouch development of male pregnant lined seahorse ( Hippocampus erectus ) at environmentally relevant concentrations . Journal of Hazardous Materials , 408 : 124854 , https://doi.org/10.1016/j.jhazmat.2020.124854 https://doi.org/10.1016/j.jhazmat.2020.124854 .

Tang Y , Han Y , Zhang W X et al . 2022 . Bisphenol A and microplastics weaken the antimicrobial ability of blood clams by disrupting humoral immune responses and suppressing hemocyte chemotactic activity . Environmental Pollution , 307 : 119497 , https://doi.‍org/10.1016/j.envpol.2022.119497 https://doi.‍org/10.1016/j.envpol.2022.119497 . https://do 10.1016/j.envpol.2022.119497 http://dx.doi.org/10.1016/j.envpol.2022.119497

Tang Y , Rong J H , Guan X F et al . 2020 . Immunotoxicity of microplastics and two persistent organic pollutants alone or in combination to a bivalve species . Environmental Pollution , 258 : 113845 , https://doi.org/10.1016/j.envpol.2019.113845 https://doi.org/10.1016/j.envpol.2019.113845 .

Vallack H W , Bakker D J , Brandt I et al . 1998 . Controlling persistent organic pollutants‍‍‍——‍‍what next? Environmental Toxicology and Pharmacology , 6 ( 3 ): 143 - 175 , https://doi.org/10.1016/S1382-6689(98)00036-2 https://doi.org/10.1016/S1382-6689(98)00036-2 .

Volkoff H , Hoskins L J , Tuziak S M . 2010 . Influence of intrinsic signals and environmental cues on the endocrine control of feeding in fish: potential application in aquaculture . General and Comparative Endocrinology , 167 ( 3 ): 352 - 359 , https://doi.‍org/10.1016/j.‍ygcen.‍2009.09.001 https://doi.‍org/10.1016/j.‍ygcen.‍2009.09.001 . https://do 10.1016/j.ygcen.2009.09.001 http://dx.doi.org/10.1016/j.ygcen.2009.09.001

Wang F Y , Yang W W , Cheng P et al . 2019 . Adsorption characteristics of cadmium onto microplastics from aqueous solutions . Chemosphere , 235 : 1073 - 1080 , https://doi.org/10.1016/j.chemosphere.2019.06.196 https://doi.org/10.1016/j.chemosphere.2019.06.196 .

Wang L , Pan L Q , Miao J J . 2010 . Single and joint toxicity of mercury, cadmium and benzo [a ] pyrene, biphenyispolychlorinated 1254 for juvenile Chlamys farreri. Marine Environmental Science , 29 ( 4 ): 535 - 540 , https://doi.‍org/10.3969/j.‍issn.‍1007-6336.2010.04.019. https://doi.‍org/10.3969/j.‍issn.‍1007-6336.2010.04.019. (in Chinese with English abstract)

Xiao G Q , Zhang J M , Shao Y Q et al . 2013 . Effect of Benzo [a ] pyrene on two enzymes activity and lipid peroxidation MAD in Tegillarca granosa. Marine Sciences , 37 ( 8 ): 28 - 34 , https://kns.cnki.net/kcms2/article/abstract?v=8c_-cgyg31eoz2qve_zjk2q7w8lmwnwm7hg70y8qjfqm8h2oekzlqu5zvempdtphtjmckq9ytwyva-dturdp0nuwddoc3qtncqo4m-urgzoms94q3b9dvp4j7pg8x_zjkxtlkon9dza=&uniplatform=nzkpt&language=chs https://kns.cnki.net/kcms2/article/abstract?v=8c_-cgyg31eoz2qve_zjk2q7w8lmwnwm7hg70y8qjfqm8h2oekzlqu5zvempdtphtjmckq9ytwyva-dturdp0nuwddoc3qtncqo4m-urgzoms94q3b9dvp4j7pg8x_zjkxtlkon9dza=&uniplatform=nzkpt&language=chs .

Xu R , Li L A , Zheng J H et al . 2023 . Combined toxic effects of nanoplastics and norfloxacin on mussel: leveraging biochemical parameters and gut microbiota . Science of the Total Environment , 880 : 163304 , https://doi.org/10.1016/j.scitotenv.2023.163304 https://doi.org/10.1016/j.scitotenv.2023.163304 .

Yang Z G , Zhu L L , Liu J N et al . 2022 . Polystyrene microplastics increase Pb bioaccumulation and health damage in the Chinese mitten crab Eriocheir sinensis . Science of the Total Environment , 829 : 154586 , https://doi.org/10.1016/j.scitotenv.2022.154586 https://doi.org/10.1016/j.scitotenv.2022.154586 .

Yu P , Liu Z Q , Wu D L et al . 2018 . Accumulation of polystyrene microplastics in juvenile Eriocheir sinensis and oxidative stress effects in the liver . Aquatic Toxicology , 200 : 28 - 36 , https://doi.org/10.1016/j.aquatox.2018.04.015 https://doi.org/10.1016/j.aquatox.2018.04.015 .

Yu Y H , Hu L H , Tian D D et al . 2023 . Toxicities of polystyrene microplastics (MPs) and hexabromocyclododecane (HBCD), alone or in combination, to the hepatopancreas of the whiteleg shrimp, Litopenaeus vannamei . Environmental Pollution , 329 : 121646 , https://doi.org/10.1016/j.envpol.2023.121646 https://doi.org/10.1016/j.envpol.2023.121646 .

Zhang Q , He Y , Cheng R J et al . 2022a . Recent advances in toxicological research and potential health impact of microplastics and nanoplastics in vivo . Environmental Science and Pollution Research , 29 ( 27 ): 40415 - 40448 , https://doi.org/10.1007/s11356-022-19745-3 https://doi.org/10.1007/s11356-022-19745-3 .

Zhang S , Wang N , Gong S M et al . 2022b . The patterns of trophic transfer of microplastic ingestion by fish in the artificial reef area and adjacent waters of Haizhou Bay . Marine Pollution Bulletin , 177 : 113565 , https://doi.org/10.1016/j.marpolbul.2022.113565 https://doi.org/10.1016/j.marpolbul.2022.113565 .

Zhang Y F , Chen S Y , Qu M J et al . 2017 . Utilization of isolated marine mussel cells as an in vitro model to assess xenobiotics induced genotoxicity . Toxicology in Vitro , 44 : 219 - 229 , https://doi.org/10.1016/j.tiv.2017.05.018 https://doi.org/10.1016/j.tiv.2017.05.018 .

Zhao P S , Wen Z N , Zhou S L . 2003 . Growth of larval Hippocampus kuda under industrial culture condition . Marine Fisheries Research , 24 ( 3 ): 15 - 19 , https://doi.‍org/10.3969/j.‍issn.‍1000-7075.2003.03.003. https://doi.‍org/10.3969/j.‍issn.‍1000-7075.2003.03.003. (in Chinese with English abstract)

Zhao S S , Yuan H G . 2018 . Effects of benzo [a ] pyrene on SOD and CAT in kidneys from carps. Agricultural Biotechnology , 7 : 124 - 126 , https://www.‍proquest.com/scholarly-journals/effects-benzo-pyrene-on-sod-cat-kidneys-carps/docview/2136836743/se-2 https://www.‍proquest.com/scholarly-journals/effects-benzo-pyrene-on-sod-cat-kidneys-carps/docview/2136836743/se-2 .

Zhao Y , Wu X Y , Xu S X et al . 2019 . Dietary tryptophan affects growth performance, digestive and absorptive enzyme activities, intestinal antioxidant capacity, and appetite and GH-IGF axis-related gene expression of hybrid catfish ( Pelteobagrus vachelli♀ × Leiocassis longirostris♂ ) . Fish Physiology and Biochemistry , 45 ( 5 ): 1627 - 1647 , https://doi.org/10.1007/s10695-019-00651-4 https://doi.org/10.1007/s10695-019-00651-4 .

Zhou C Y , Bi R , Su C H et al . 2022 . The emerging issue of microplastics in marine environment: a bibliometric analysis from 2004 to 2020 . Marine Pollution Bulletin , 179 : 113712 , https://doi.org/10.1016/j.marpolbul.2022.113712 https://doi.org/10.1016/j.marpolbul.2022.113712 .

Zhou W S , Shi W , Du X Y et al . 2023a . Assessment of nonalcoholic fatty liver disease symptoms and gut‍‍‍–‍liver axis status in zebrafish after exposure to polystyrene microplastics and oxytetracycline, alone and in combination . Environmental Health Perspectives , 131 ( 4 ): 047006 , https://doi.org/10.1289/EHP11600 https://doi.org/10.1289/EHP11600 .

Zhou W S , Tong D F , Tian D D et al . 2023b . Exposure to polystyrene nanoplastics led to learning and memory deficits in zebrafish by inducing oxidative damage and aggravating brain aging . Advanced Healthcare Materials , 12 ( 29 ): 2301799 , https://doi.org/10.1002/adhm.202301799 https://doi.org/10.1002/adhm.202301799 .

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Temporal dynamics of bacterial biofilms and their relationship with heavy metals on expanded polystyrene microplastics

Microplastics in sediment of the Three Gorges Reservoir: abundance and characteristics under different environmental conditions

Assessment of heavy metal pollution in Laizhou Bay (China) using the ecological risk index and the integrated biomarker response of the goby Acanthogobius ommaturus

Heavy metals in sediments of Yellow Sea and East China Sea: Chemical speciation, distribution, influence factor, and contamination

一种涡轮基组合动力的整机低速风洞试验研究

The toxic impacts of microplastics-borne benzo[a]pyrene and heavy metals on the health and behavior of seahorse Hippocampus erectus

The toxic impacts of microplastics-borne benzo[a]pyrene and heavy metals on the health and behavior of seahorse Hippocampus erectus

DOI：10.1007/s00343-024-3249-z

摘要

Abstract

关键词

Keywords

references