Quinosumycin, a novel anti-MRSA thioether-linked quinolinone-quinazolinone heterodimer from a marine actinomycete <italic style="font-style: italic">Streptomyces diastaticus</italic> NBU2966

Shuangling TAN; Yang LIU; Haonan FU; Yutong XUE; Fangjian FENG; Jinling LI; Xiaojun YAN; Sitong WU; Shan HE; Lijian DING

doi:10.1007/s00343-024-3195-9

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Quinosumycin, a novel anti-MRSA thioether-linked quinolinone-quinazolinone heterodimer from a marine actinomycete Streptomyces diastaticus NBU2966

Biology | Updated：2024-12-24

- Quinosumycin, a novel anti-MRSA thioether-linked quinolinone-quinazolinone heterodimer from a marine actinomycete Streptomyces diastaticus NBU2966
- Quinosumycin, a novel anti-MRSA thioether-linked quinolinone-quinazolinone heterodimer from a marine actinomycete Streptomyces diastaticus NBU2966
- 海洋湖沼学报(英文) 2024年42卷第6期页码：1991-1997
- Affiliations：
  
  1.Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo315211, China
  2.Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou318053, China
  3.School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou310014, China
  4.Ningbo Institute of Marine Medicine, Peking University, Ningbo315800, China
- Author bio：
  
  heshan@nbu.edu.cn
  dinglijian@nbu.edu.cn
- Funds：
  
  the National Natural Science Foundation of China(42176101);the Ningbo Youth Science and Technology Innovation Leading Project(2024QL063);the National 111 Project of China(D16013);the Scientific Research Fund of Zhejiang Provincial Education Department(Y202250186);the Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Development Fund
- DOI：10.1007/s00343-024-3195-9
  中图分类号：
- 收稿：2023-10-17，
  
  纸质出版：2024-11-01
- Accepted：
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Quinosumycin, a novel anti-MRSA thioether-linked quinolinone-quinazolinone heterodimer from a marine actinomycete Streptomyces diastaticus NBU2966[J]. 海洋湖沼学报(英文), 2024,42(6):1991-1997.

TAN Shuangling,LIU Yang,FU Haonan,et al.Research Paper Quinosumycin, a novel anti-MRSA thioether-linked quinolinone-quinazolinone heterodimer from a marine actinomycete ,Streptomyces diastaticus NBU2966[J].Journal of Oceanology and Limnology,2024,42(06):1991-1997.
Quinosumycin, a novel anti-MRSA thioether-linked quinolinone-quinazolinone heterodimer from a marine actinomycete Streptomyces diastaticus NBU2966[J]. 海洋湖沼学报(英文), 2024,42(6):1991-1997. DOI： 10.1007/s00343-024-3195-9.

TAN Shuangling,LIU Yang,FU Haonan,et al.Research Paper Quinosumycin, a novel anti-MRSA thioether-linked quinolinone-quinazolinone heterodimer from a marine actinomycete ,Streptomyces diastaticus NBU2966[J].Journal of Oceanology and Limnology,2024,42(06):1991-1997. DOI： 10.1007/s00343-024-3195-9.

摘要

Abstract

Marine natural products offer a promising source in the development of new antibiotic drugs. Two previously undescribed compounds

including one sulfur-bearing alkaloid named quinosumycin (

) along with one chromone derivative namely chromycone (

)

were discovered from an ethyl acetate (EtOAc) extract of marine

Streptomyces diastaticus

NBU2966 through a bioactivity-guided isolation prioritized for antimicrobial potential. The analysis of nuclear magnetic resonance (NMR) spectroscopy

high resolution electrospray ionization mass spectroscopy (HRESIMS) data

and electronic circular dichroism (ECD) calculations enabled the elucidation of their structures and the determination of their absolute configurations. Quinosumycin (

) is the first heterodimer scaffold incorporating quinolinone and quinazolinone motifs coupled by a thioether bond. Interestingly

Compound

exhibited a relatively selective growth inhibition against methicillin-resistant

Staphylococcus aureus

(MRSA) with the minimal inhibitory concentration (MIC) value of 8 μg/mL.

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references

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Quinosumycin, a novel anti-MRSA thioether-linked quinolinone-quinazolinone heterodimer from a marine actinomycete Streptomyces diastaticus NBU2966

Quinosumycin, a novel anti-MRSA thioether-linked quinolinone-quinazolinone heterodimer from a marine actinomycete Streptomyces diastaticus NBU2966

DOI：10.1007/s00343-024-3195-9

摘要

Abstract

关键词

Keywords

references