Bioactive chemical constituents from the marine-derived fungus <italic style="font-style: italic">Cladosporium </italic>sp. DLT-5

Luting DAI; Qingyi XIE; Jiaocen GUO; Qingyun MA; Li YANG; Jingzhe YUAN; Haofu DAI; Zhifang YU; Youxing ZHAO

doi:10.1007/s00343-023-3084-7

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Bioactive chemical constituents from the marine-derived fungus Cladosporium sp. DLT-5

Biology | Updated：2026-05-18

- Bioactive chemical constituents from the marine-derived fungus Cladosporium sp. DLT-5
- Bioactive chemical constituents from the marine-derived fungus Cladosporium sp. DLT-5
- 海洋湖沼学报(英文) 2024年42卷第3期页码：905-914
- Affiliations：
  
  1.College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
  2.Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences & Hainan Academy of Tropical Agricultural Resource, Haikou 571101, China
- Author bio：
  
  yuzhifang@njau.edu.cn
  zhaoyouxing@itbb.org.cn
- Funds：
  
  the China Agriculture Research System of MOF and MARA(CARS-21);the Financial Fund of the Ministry of Agriculture and Rural Affairs, China(NFZX2021);the National Natural Science Foundation of China(81973568)
- DOI：10.1007/s00343-023-3084-7
  中图分类号：
- 收稿：2023-05-16，
  
  录用：2023-06-24，
  
  网络首发：2023-07-17，
  
  纸质出版：2024-05-01
- Accepted：
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Luting DAI, Qingyi XIE, Jiaocen GUO, 等. Bioactive chemical constituents from the marine-derived fungus Cladosporium sp. DLT-5[J]. 海洋湖沼学报(英文), 2024,42(3):905-914. DOI: 10.1007/s00343-023-3084-7.

DAI Luting,XIE Qingyi,GUO Jiaocen,et al.Bioactive chemical constituents from the marine-derived fungus Cladosporium sp. DLT-5[J].Journal of Oceanology and Limnology,2024,42(03):905-914.
Luting DAI, Qingyi XIE, Jiaocen GUO, 等. Bioactive chemical constituents from the marine-derived fungus Cladosporium sp. DLT-5[J]. 海洋湖沼学报(英文), 2024,42(3):905-914. DOI: 10.1007/s00343-023-3084-7. DOI：

DAI Luting,XIE Qingyi,GUO Jiaocen,et al.Bioactive chemical constituents from the marine-derived fungus Cladosporium sp. DLT-5[J].Journal of Oceanology and Limnology,2024,42(03):905-914. DOI： 10.1007/s00343-023-3084-7.

摘要

Abstract

A new isochromanone

cladosporinisochromanone (

)

accompanied by 15 known compounds (

–

) were obtained from secondary metabolites produced by marine-derived fungus

Cladosporium

sp. DLT-5. NMR and HRESIMS spectra elucidation determined the planar structure of

. Subsequent electronic circular dichroism (ECD) experiment assigned the absolute configuration of

. Compounds

–

and

displayed different degrees of neuroprotective activities on human neuroblastoma cells SH-SY5Y. Five compounds (

–

and

) emerged resistance to protein tyrosine phosphatase 1B (PTP1B)

further kinetic analysis and molecular docking study indicated that the most potent compound

(IC

value of 10.74±0.61 μmol/L) was found as a noncompetitive inhibitor for PTP1B. Surface plasmon resonance (SPR) and molecular docking studies also demonstrated the interaction between compound

and Niemann-Pick C1 Like 1 (NPC1L1)

which has been identified as significant therapeutic target for hypercholesteremia. In addition

compounds

and

showed attractive inhibitory activity against the phytopathogenic fungi:

Colletotrichum capsici

. Therefore

library of

Cladosporium

metabolites is enriched and new active uses of known compounds are explored.

关键词

Keywords

references

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Bioactive chemical constituents from the marine-derived fungus Cladosporium sp. DLT-5

Bioactive chemical constituents from the marine-derived fungus Cladosporium sp. DLT-5

DOI：10.1007/s00343-023-3084-7

摘要

Abstract

关键词

Keywords

references