Differential expression of miRNAs and mRNAs in the livers of largemouth bass <italic style="font-style: italic">Micropterus</italic> <italic style="font-style: italic">salmoides</italic> under heat stress

Xuqian ZHAO; Zijie LIN; Caijuan LI; Hao ZHU; Lingling LI; Wenjia MAO; Qufei LING

doi:10.1007/s00343-023-3003-y

Your Location：

Home >

Browse articles >

Differential expression of miRNAs and mRNAs in the livers of largemouth bass Micropterus salmoides under heat stress

Biology | Updated：2024-10-11

- Differential expression of miRNAs and mRNAs in the livers of largemouth bass Micropterus salmoides under heat stress
- Differential expression of miRNAs and mRNAs in the livers of largemouth bass Micropterus salmoides under heat stress
- 海洋湖沼学报(英文) 2024年42卷第2期页码：594-608
- Affiliations：
  
  School of Biology and Basic Medical Sciences, Suzhou Medical College of Soochow University, Suzhou 215000, China
- Author bio：
  
  lingqf@suda.edu.cn
- Funds：
  
  the Scientific Fund of Jiangsu Province(BY2015039-10);the Aquatic Three Project of Jiangsu Province(Y2017-37);the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), the Top-notch Academic Programs Project of Jiangsu Higher Education Institutions (TAPP), and the Jiangsu Funding Program for Excellent Postdoctoral Talent
- DOI：10.1007/s00343-023-3003-y
  中图分类号：
- 收稿：2023-01-02，
  
  网络首发：2023-05-05，
  
  纸质出版：2024-03-01
- Accepted：
Scan QR Code
Differential expression of miRNAs and mRNAs in the livers of largemouth bass Micropterus salmoides under heat stress[J]. 海洋湖沼学报(英文), 2024,42(2):594-608.

ZHAO Xuqian,LIN Zijie,LI Caijuan,et al.Differential expression of miRNAs and mRNAs in the livers of largemouth bass Micropterussalmoides under heat stress[J].Journal of Oceanology and Limnology,2024,42(02):594-608.
Differential expression of miRNAs and mRNAs in the livers of largemouth bass Micropterus salmoides under heat stress[J]. 海洋湖沼学报(英文), 2024,42(2):594-608. DOI： 10.1007/s00343-023-3003-y.

ZHAO Xuqian,LIN Zijie,LI Caijuan,et al.Differential expression of miRNAs and mRNAs in the livers of largemouth bass Micropterussalmoides under heat stress[J].Journal of Oceanology and Limnology,2024,42(02):594-608. DOI： 10.1007/s00343-023-3003-y.

摘要

Abstract

Global warming threatens freshwater ecosystems and compromises fish survival. To elucidate the role of miRNAs in the livers of heat stressed largemouth bass

juvenile fish was subject to heat stress under 37 °‍‍C. Both mRNA-seq and miRNA-seq were conducted on the liver tissues under control and heat stress conditions. Differential gene expression analysis and enrichment analysis were performed on mRNA and miRNA expression profiles. A total of 406 differentially expressed genes (DEGs) were discovered

of which 212 were up-regulated and 194 were down-regulated. Most of the DEGs were significantly implicated in the regulation of “protein processing in endoplasmic reticulum”

“proteasome”

“steroid biosynthesis”

and “ornithine decarboxylase inhibitor activity” pathways. In addition

47 differentially expressed miRNAs (DEMs) were identified in largemouth bass livers under heat stress

including 21 up-regulated and 25 down-regulated miRNAs. A negatively regulated miRNA-mRNA network including 12 miRNAs and 19 mRNAs was constructed with DEMs involved in “protein degradation”

“calcium ion regulation”

“cell apoptosis”

and “lipid metabolism”. Moreover

this study indicated novel-miR-144 activated the IRE1 signaling pathway by targeting txndc5 to induce liver apoptosis in largemouth bass under heat stress. This study revealed the involvement of miRNA regulation in largemouth bass in response to heat stress.

关键词

Keywords

references

Alfonso S , Gesto M , Sadoul B . 2021 . Temperature increase and its effects on fish stress physiology in the context of global warming . Journal of Fish Biology , 98 ( 6 ): 1496 - 1508 , https://doi.org/10.1111/jfb.14599 https://doi.org/10.1111/jfb.14599 .

Ashburner M , Ball C A , Blake J A et al . 2000 . Gene Ontology: tool for the unification of biology . Nature Genetics , 25 ( 1 ): 25 - 29 , https://doi.org/10.1038/75556 https://doi.org/10.1038/75556 .

Bae M J , Murphy C A , García-Berthou E . 2018 . Temperature and hydrologic alteration predict the spread of invasive Largemouth Bass ( Micropterus salmoides ) . Science of the Total Environment , 639 : 58 - 66 , https://doi.org/10.1016/j.scitotenv.2018.05.001 https://doi.org/10.1016/j.scitotenv.2018.05.001 .

Bairoch A , Apweiler R . 1997 . The SWISS-PROT protein sequence data bank and its supplement TrEMBL . Nucleic Acids Research , 25 ( 1 ): 31 - 36 , https://doi.org/10.1093/nar/25.1.31 https://doi.org/10.1093/nar/25.1.31 .

Bao W D , Kojima K K , Kohany O . 2015 . Repbase Update, a database of repetitive elements in eukaryotic genomes . Mobile DNA , 6 : 11 , https://doi.org/10.1186/s13100-015-0041-9 https://doi.org/10.1186/s13100-015-0041-9 .

Bindea G , Mlecnik B , Hackl H et al . 2009 . ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks . Bioinformatics , 25 ( 8 ): 1091 - 1093 , https://doi.org/10.1093/bioinformatics/btp101 https://doi.org/10.1093/bioinformatics/btp101 .

Bulanova D , Ianevski A , Bugai A et al . 2017 . Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins . Viruses , 9 ( 10 ): 271 , https://doi.org/10.3390/v9100271 https://doi.org/10.3390/v9100271 .

Cai L S , Wang L , Song K et al . 2020 . Evaluation of protein requirement of spotted seabass ( Lateolabrax maculatus ) under two temperatures, and the liver transcriptome response to thermal stress . Aquaculture , 516 : 734615 , https://doi.org/10.1016/j.aquaculture.2019.734615 https://doi.org/10.1016/j.aquaculture.2019.734615 .

Chan P P , Lowe T M . 2009 . GtRNAdb: A database of transfer RNA genes detected in genomic sequence . Nucleic Acids Research , 37 (Database issue): D93 - D97 , https://doi.org/10.1093/nar/gkn787 https://doi.org/10.1093/nar/gkn787 .

Chen J Q , Zhang S , Tong J Y et al . 2020 . Whole transcriptome-based miRNA-mRNA network analysis revealed the mechanism of inflammation-immunosuppressive damage caused by cadmium in common carp spleens . Science of the Total Environment , 717 : 137081 , https://doi.org/10.1016/j.scitotenv.2020.137081 https://doi.org/10.1016/j.scitotenv.2020.137081 .

Cheng C H , Guo Z X , Luo S W et al . 2018 . Effects of high temperature on biochemical pa rameters, oxidative stress, DNA damage and apoptosis of pufferfish ( Takifugu obscurus ) . Ecotoxicology and Environmental Safety , 150 : 190 - 198 , https://doi.org/10.1016/j.ecoenv.2017.12.045 https://doi.org/10.1016/j.ecoenv.2017.12.045 .

Cui J W , Zhou Q , Yu M J et al . 2022 . 4-tert-butylphenol triggers common carp hepatocytes ferroptosis via oxidative stress, iron overload, SLC 7 A11/GSH/GPX4 axis, and ATF4/HSPA5/GPX4 axis . Ecotoxicology and Environmental Safety , 242 : 113944 , https://doi.org/10.1016/j.ecoenv.2022.113944 https://doi.org/10.1016/j.ecoenv.2022.113944 .

Cui J W , Qiu M N , Liu Y H et al . 2023 . Nano-selenium protects grass carp hepatocytes against 4-tert-butylphenol-induced mitochondrial apoptosis and necroptosis via suppressing ROS-PARP1 axis . Fish & Shellfish Immunology , 135 : 108682 , https://doi.org/10.1016/j.fsi.2023.108682 https://doi.org/10.1016/j.fsi.2023.108682 .

Dalmadi Á , Gyula P , Bálint J et al . 2019 . AGO-unbound cytosolic pool of mature miRNAs in plant cells reveals a novel regulatory step at AGO1 loading . Nucleic Acids Research , 47 ( 18 ): 9803 - 9817 , https://doi.org/10.1093/nar/gkz690 https://doi.org/10.1093/nar/gkz690 .

Díaz F , Re A D , González R A et al . 2007 . Temperature preference and oxygen consumption of the largemouth bass Micropterus salmoides (Lacépède) acclimated to different temperatures . Aquaculture Research , 38 ( 13 ): 1387 - 1394 , https://doi.org/10.1111/j.1365-2109.2007.01817.x https://doi.org/10.1111/j.1365-2109.2007.01817.x .

Enright A J , John B , Gaul U et al . 2003 . MicroRNA targets in Drosophila . Genome Biology , 5 ( 1 ): R1 , https://doi.org/10.1186/gb-2003-5-1-r1 https://doi.org/10.1186/gb-2003-5-1-r1 .

Fernandes L M , Al-Dwairi A , Simmen R C M et al . 2018 . Malic Enzyme 1 (ME1) is pro-oncogenic in Apc Min/+ mice . Scientific Reports , 8 ( 1 ): 14268 , https://doi.org/10.1038/s41598-018-32532-w https://doi.org/10.1038/s41598-018-32532-w .

Friedländer M R , MacKowiak S D , Li N et al . 2012 . MiRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades . Nucleic Acids Research , 40 ( 1 ): 37 - 52 , https://doi.org/10.1093/nar/gkr688 https://doi.org/10.1093/nar/gkr688 .

Grabherr M G , Haas B J , Yassour M et al . 2011 . Full-length transcriptome assembly from RNA-Seq data without a reference genome . Nature Biotechnology , 29 ( 7 ): 644 - 652 , https://doi.org/10.1038/nbt.1883 https://doi.org/10.1038/nbt.1883 .

Huang H Y , Chang K Y , Wu S J . 2018 . High irradiance sensitive phenotype of Arabidopsis hit2 / xpo1a mutant is caused in part by nuclear confinement of AtHsfA4a . Biologia Plantarum , 62 ( 1 ): 69 - 79 , https://doi.org/10.1007/s10535-017-0753-4 https://doi.org/10.1007/s10535-017-0753-4 .

Huang X L , Liu S , Chen X et al . 2021 . Comparative pathological description of nocardiosis in largemouth bass ( Micropterus salmoides ) and other Per ciformes . Aquaculture , 534 : 736193 , https://doi.‍org/10.1016/j.aquaculture.2020.736193 https://doi.‍org/10.1016/j.aquaculture.2020.736193 . https://do 10.1016/j.aquaculture.2020.736193 http://dx.doi.org/10.1016/j.aquaculture.2020.736193

Johnson N C , Xie S P , Kosaka Y et al . 2018 . Increasing occurrence of cold and warm extremes during the recent global warming slowdown . Nature Communications , 9 : 1724 , https://doi.org/10.1038/s41467-018-04040-y https://doi.org/10.1038/s41467-018-04040-y .

Kalvari I , Nawrocki E P , Ontiveros-Palacios N et al . 2021 . Rfam 14: Expanded coverage of metagenomic, viral and microRNA families . Nucleic Acids Research , 49 ( D1 ): D192 - D200 , https://doi.org/10.1093/nar/gkaa1047 https://doi.org/10.1093/nar/gkaa1047 .

Kanehisa M , Goto S , Furumichi M et al . 2010 . KEGG for representation and analysis of molecular networks involving diseases and drugs . Nucleic Acids Research , 38 (Database issue): D355 - D360 , https://doi.org/10.1093/nar/gkp896 https://doi.org/10.1093/nar/gkp896 .

Kao Y C , Rogers M W , Bunnell D B et al . 2020 . Effects of climate and land-use changes on fish catches across lakes at a global scale . Nature Communications , 11 : 2526 , https://doi.org/10.1038/s41467-020-14624-2 https://doi.org/10.1038/s41467-020-14624-2 .

Karmon O , Aroya S B . 2020 . Spatial organization of proteasome aggregates in the regulation of proteasome homeostasis . Frontiers in Molecular Biosciences , 6 : 150 , https://doi.org/10.3389/fmolb.2019.00150 https://doi.org/10.3389/fmolb.2019.00150 .

Kassahn K S , Crozier R H , Ward A C et al . 2007 . From transcriptome to biological function: environmental stress in an ectothermic vertebrate, the coral reef fish Pomacentrus moluccensis . BMC Genomics , 8 : 358 , https://doi.org/10.1186/1471-2164-8-358 https://doi.org/10.1186/1471-2164-8-358 .

Kelly C E , Thymiakou E , Dixon J E et al . 2013 . Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension . PLoS Biology , 11 ( 4 ): e1001538 , https://doi.org/10.1371/journal.pbio.1001538 https://doi.org/10.1371/journal.pbio.1001538 .

Kimura J , Nguyen S T , Liu H S et al . 2008 . A functional genome-wide RNAi screen identifies TAF1 as a regulator for apoptosis in response to genotoxic stress . Nucleic Acids Research , 36 ( 16 ): 5250 - 5259 , https://doi.org/10.1093/nar/gkn506 https://doi.org/10.1093/nar/gkn506 .

Kraus M , Greither T , Wenzel C et al . 2015 . Inhibition of adipogenic differentiation of human SGBS preadipocytes by androgen-regulated microRNA miR-375 . Molecular and Cellular Endocrinology , 414 : 177 - 185 , https://doi.org/10.1016/j.mce.2015.07.026 https://doi.org/10.1016/j.mce.2015.07.026 .

Langmead B , Trapnell C , Pop M et al . 2009 . Ultrafast and memory-efficient alignment of short DNA sequences to the human genome . Genome Biology , 10 ( 3 ): R25 , https://doi.org/10.1186/gb-2009-10-3-r25 https://doi.org/10.1186/gb-2009-10-3-r25 .

Lee T H , Yeh C F , Lee Y T et al . 2020 . Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization . Nature Communications , 11 ( 1 ): 4254 , https://doi.org/10.1038/s41467-020-18047-x https://doi.org/10.1038/s41467-020-18047-x .

Li B , Dewey C N . 2011 . RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome . BMC Bioinformatics , 12 : 323 , https://doi.org/10.1186/1471-2105-12-323 https://doi.org/10.1186/1471-2105-12-323 .

Link N , Chung H , Jolly A et al . 2019 . Mutations in ANKLE2 , a ZIKA virus target, disrupt an asymmetric cell division pathway in Drosophila neuroblasts to cause microcephaly . Developmental Cell , 51 ( 6 ): 713 - 729.e6 , https://doi.org/10.1016/j.devcel.2019.10.009 https://doi.org/10.1016/j.devcel.2019.10.009 .

Love M I , Huber W , Anders S . 2014 . Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 . Genome Biology , 15 ( 12 ): 550 , https://doi.org/10.1186/s13059-014-0550-8 https://doi.org/10.1186/s13059-014-0550-8 .

McGeary S E , Lin K S , Shi C Y et al . 2019 . The biochemical basis of microRNA targeting efficacy . Science , 366 ( 6472 ): eaav 1741 , https://doi.org/10.1126/science.aav1741 https://doi.org/10.1126/science.aav1741 .

Miao Z Y , Miao Z R , Teng X H et al . 2022 . Melatonin alleviates lead-induced intestinal epithelial cell pyroptosis in the common carps ( Cyprinus carpio ) via miR-17-5p/TXNIP axis . Fish and Shellfish Immunology , 131 : 127 - 136 , https://doi.org/10.1126/j.fsi.2022.09.071 https://doi.org/10.1126/j.fsi.2022.09.071 .

Mistry J , Chuguransky S , Williams L et al . 2021 . Pfam: the protein family's database in 2021 . Nucleic Acids Research , 49 ( D1 ): D412 - D419 , https://doi.org/10.1093/nar/gkaa913 https://doi.org/10.1093/nar/gkaa913 .

Mori M A , Ludwig R G , Garcia-Martin R et al . 2019 . Extracellular miRNAs: from biomarkers to mediators of physiology and disease . Cell Metabolism , 30 ( 4 ): 656 - 673 , https://doi.org/10.1016/j.cmet.2019.07.011 https://doi.org/10.1016/j.cmet.2019.07.011 .

Narum S R , Campbell N R . 2015 . Transcriptomic response to heat stress among ecologically divergent populations of redband trout . BMC Genomics , 16 : 103 , https://doi.org/10.1186/s12864-015-1246-5 https://doi.org/10.1186/s12864-015-1246-5 .

NCBI Resource Coordinators . 2018 . Database resources of the national center for biotechnology information . Nucleic Acids Research , 46 ( D1 ): D8 - D13 , https://doi.org/10.1093/nar/gkx1095 https://doi.org/10.1093/nar/gkx1095 .

Newton J R , Zenger K R , Jerry D R . 2013 . Next-generation transcriptome profiling reveals insights into genetic factors contributing to growth differences and temperature adaptation in Australian populations of barramundi ( Lates calcarifer ) . Marine Genomics , 11 : 45 - 52 , https://doi.org/10.1016/j.margen.2013.07.002 https://doi.org/10.1016/j.margen.2013.07.002 .

Nguinkal J A , Brunner R M , Verleih M et al . 2019 . The first highly contiguous genome assembly of pikeperch ( Sander lucioperca ), an emerging aquaculture species in Europe . Genes , 10 ( 9 ): 708 , https://doi.org/10.3390/genes10090708 https://doi.org/10.3390/genes10090708 .

Olusanya H O , van Zyll de Jong M . 2018 . Assessing the vulnerability of freshwater fishes to climate change in Newfoundland and Labrador . PLoS One , 13 ( 12 ): e0208182 , https://doi.org/10.1371/journal.pone.0208182 https://doi.org/10.1371/journal.pone.0208182 .

Peng F S , Zhang H L , Du Y H et al . 2018 . Cetuximab enhances cisplatin-induced endoplasmic reticulum stress-associated apoptosis in laryngeal squamous cell carcinoma cells by inhibiting expression of TXNDC5 . Molecular Medicine Reports , 17 ( 3 ): 4767 - 4776 , https://doi.org/10.3892/mmr.2018.8376 https://doi.org/10.3892/mmr.2018.8376 .

Quast C , Pruesse E , Yilmaz P et al . 2013 . The SILVA ribosomal RNA gene database project: improved data processing and web-based tools . Nucleic Acids Research , 41 (Database issue): D590 - D596 , https://doi.org/10.1093/nar/gks1219 https://doi.org/10.1093/nar/gks1219 .

Raza S H A , Abdelnour S A , Alotaibi M A et al . 2022 . MicroRNAs mediated environmental stress responses and toxicity signs in teleost fish species . Aquaculture , 546 : 737310 , https://doi.org/10.1016/j.aquaculture.2021.737310 https://doi.org/10.1016/j.aquaculture.2021.737310 .

Shannon P , Markiel A , Ozier O et al . 2003 . Cytoscape: A software Environment for integrated models of biomolecular interaction networks . Genome Research , 13 ( 11 ): 2498 - 2504 , https://doi.org/10.1101/gr.1239303 https://doi.org/10.1101/gr.1239303 .

Shi K P , Dong S L , Zhou Y G et al . 2019 . RNA-seq reveals temporal differences in the transcriptome response to acute heat stress in the Atlantic salmon ( Salmo salar ) . Comparative Biochemistry and Physiology Part D: Genomics and Proteomics , 30 : 169 - 178 , https://doi.org/10.1016/j.cbd.2018.12.011 https://doi.org/10.1016/j.cbd.2018.12.011 .

Sita K , Sehgal A , Hanumantharao B et al . 2017 . Food legumes and rising temperatures: effects, adaptive functional mechanisms specific to reproductive growth stage and strategies to improve heat tolerance . Frontiers in Plant Science , 8 : 1658 , https://doi.org/10.3389/fpls.2017.01658 https://doi.org/10.3389/fpls.2017.01658 .

Sun J L , Zhao L L , Wu H et al . 2019 . Analysis of miRNA-seq in the liver of common carp ( Cyprinus carpio L.) in response to different environmental temperatures . Functional and Integrative Genomics , 19 ( 2 ): 265 - 280 , https://doi.org/10.1007/s10142-018-0643-7 https://doi.org/10.1007/s10142-018-0643-7 .

Sun J L , Zhao L L , He K et al . 2020 . MiRNA-mRNA integration analysis reveals the regulatory roles of miRNAs in the metabolism of largemouth bass ( Micropterus salmoides ) livers during acute hypoxic stress . Aquaculture , 526 : 735362 , https://doi.org/10.1016/J.AQUACULTURE.2020.735362 https://doi.org/10.1016/J.AQUACULTURE.2020.735362 .

Wang C , Zhou Y L , Zhu Q H et al . 2018 . Effects of heat stress on the liver of the Chinese giant salamander Andrias davidianus : histopathological changes and expression characterization of Nrf2-mediated antioxidant pathway genes . Journal of Thermal Biology , 76 : 115 - 125 , https://doi.org/10.1016/j.jtherbio.2018.07.016 https://doi.org/10.1016/j.jtherbio.2018.07.016 .

Wang H Y , Yuan J , Dang X Q et al . 2021 . Mettl14-mediated m6A modification modulates neuron apoptosis during the repair of spinal cord injury by regulating the transformation from pri-mir-375 to miR-375 . Cell and Bioscience , 11 ( 1 ): 52 , https://doi.org/10.1186/s13578-020-00526-9 https://doi.org/10.1186/s13578-020-00526-9 .

Wang X Q , Gao Y Z , Li Y et al . 2020 . Roseotoxin B alleviates cholestatic liver fibrosis through inhibiting PDGF-B/PDGFR-β pathway in hepatic stellate cells . Cell Death and Disease , 11 ( 6 ): 458 , https://doi.org/10.1038/s41419-020-2575-0 https://doi.org/10.1038/s41419-020-2575-0 .

Wang Y F , Li C J , Pan C L et al . 2019 . Alterations to transcriptomic profile, histopathology, and oxidative stress in liver of pikeperch ( Sander lucioperca ) under heat stress . Fish and Shellfish Immunology , 95 : 659 - 669 , https://doi.org/10.1016/j.fsi.2019.11.014 https://doi.org/10.1016/j.fsi.2019.11.014 .

White D P , Wahl D H . 2020 . Growth and physiological responses in largemouth bass populations to environmental warming: effects of inhabiting chronically heated environments . Journal of Thermal Biology , 88 : 102467 , https://doi.org/10.1016/j.jtherbio.2019.102467 https://doi.org/10.1016/j.jtherbio.2019.102467 .

Woolway R I , Merchant C J . 2019 . Worldwide alteration of lake mixing regimes in response to climate change . Nature Geoscience , 12 ( 4 ): 271 - 276 , https://doi.‍org/10.1038/s41561-019-0322-x https://doi.‍org/10.1038/s41561-019-0322-x . https://do 10.1038/s41561-019-0322-x http://dx.doi.org/10.1038/s41561-019-0322-x

Xiang X J , Han S Z , Xu D et al . 2021 . Effects of DGAT1 inhibition on hepatic lipid deposition, antioxidant capacity and inflammatory response in Larimichthys crocea . Aquaculture , 543 : 736967 , https://doi.org/10.1016/j.aquaculture.2021.736967 https://doi.org/10.1016/j.aquaculture.2021.736967 .

Yu D , Zhang Z , Shen Z Y et al . 2018 . Regional differences in thermal adaptation of a cold-water fish Rhynchocypris oxycephalus revealed by thermal tolerance and transcriptomic responses . Scientific Reports , 8 ( 1 ): 11703 , https://doi.org/10.1038/s41598-018-30074-9 https://doi.org/10.1038/s41598-018-30074-9 .

Zhang J Y , Tao B H , Chong Y R et al . 2020 . Ornithine and breast cancer: a matched case‍‍‍-‍control study . Scientific Reports , 10 ( 1 ): 15502 , https://doi.org/10.1038/s41598-020-72699-9 https://doi.org/10.1038/s41598-020-72699-9 .

Zhao X Q , Li L L , Li C J et al . 2022 . Heat stress-induced endoplasmic reticulum stress promotes liver apoptosis in largemouth bass ( Micropterus salmoides ) . Aquaculture , 546 : 737401 , https://doi.org/10.1016/j.aquaculture.2021.737401 https://doi.org/10.1016/j.aquaculture.2021.737401 .

Zhou C Q , Zhou P , Ren Y L et al . 2019 . Physiological response and miRNA-mRNA interaction analysis in the head kidney of rainbow trout exposed to acute heat stress . Journal of Thermal Biology , 83 : 134 - 141 , https://doi.org/10.1016/J.JTHERBIO.2019.05.014 https://doi.org/10.1016/J.JTHERBIO.2019.05.014 .

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Heat stress induced hepatocyte apoptosis in largemouth bass Micropterus salmoides via IRE1α/TRAF2/ASK1/JNK pathway

Physiological and histological responses of Phascolosoma esculenta (Sipuncula: Phascolosomatidea) to acute heat stress

PSI-driven cyclic electron flow partially alleviates the peroxidation of red alga Gelidium amansii (Gelidiaceae) caused by temporary high temperature

The scleractinian coral Pocillopora damicornis Linnaeus, 1758 released polyps with different physiological characteristics under heat stress

高压涡轮封严流与主流相互作用的机理研究

Differential expression of miRNAs and mRNAs in the livers of largemouth bass Micropterus salmoides under heat stress

Differential expression of miRNAs and mRNAs in the livers of largemouth bass Micropterus salmoides under heat stress

DOI：10.1007/s00343-023-3003-y

摘要

Abstract

关键词

Keywords

references