Effects of pyraclostrobin on growth, oxidative stress, and gene expression in relation to stress and ATP-binding cassette transporters in <italic style="font-style: italic">Tetrahymena</italic> <italic style="font-style: italic">thermophila</italic>

Yang LIU; Jiale ZHANG; Peng XIAO; Xin LIU; Yisifu MA; Jing ZHANG; Bangjun ZHANG

doi:10.1007/s00343-023-2378-0

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Effects of pyraclostrobin on growth, oxidative stress, and gene expression in relation to stress and ATP-binding cassette transporters in Tetrahymena thermophila

Ecology | Updated：2024-10-15

- Effects of pyraclostrobin on growth, oxidative stress, and gene expression in relation to stress and ATP-binding cassette transporters in Tetrahymena thermophila
- Effects of pyraclostrobin on growth, oxidative stress, and gene expression in relation to stress and ATP-binding cassette transporters in Tetrahymena thermophila
- 海洋湖沼学报(英文) 2024年42卷第1期页码：150-162
- Affiliations：
  
  1.Henan International Joint Laboratory of Aquatic Ecotoxicology and Health Protection, Xinxiang 453007, China
  2.College of Life Sciences, Henan Normal University, Xinxiang 453007, China
  3.Journal of Henan Normal University, Xinxiang 453007, China
  4.College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China
  5.Department of Ecosystem Studies, School of Environmental Science, University of Shiga Prefecture, Shiga 522-8533, Japan
- Author bio：
  
  zjl@htu.cn
  zhangbangjun@htu.cn
- Funds：
  
  the Key Scientific Research Projects of Henan Province to College Youth Backbone Teacher(2021118);the National Key Research and Development Program of China(2021YFE0112000)
- DOI：10.1007/s00343-023-2378-0
  中图分类号：
- 收稿：2022-11-28，
  
  录用：2023-01-31，
  
  网络首发：2023-02-28，
  
  纸质出版：2024-01-03
- Accepted：
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Effects of pyraclostrobin on growth, oxidative stress, and gene expression in relation to stress and ATP-binding cassette transporters in Tetrahymena thermophila[J]. 海洋湖沼学报(英文), 2024,42(1):150-162.

LIU Yang,ZHANG Jiale,XIAO Peng,et al.Research PaperEffects of pyraclostrobin on growth, oxidative stress, and gene expression in relation to stress and ATP-binding cassette transporters in Tetrahymenathermophila[J].Journal of Oceanology and Limnology,2024,42(01):150-162.
Effects of pyraclostrobin on growth, oxidative stress, and gene expression in relation to stress and ATP-binding cassette transporters in Tetrahymena thermophila[J]. 海洋湖沼学报(英文), 2024,42(1):150-162. DOI： 10.1007/s00343-023-2378-0.

LIU Yang,ZHANG Jiale,XIAO Peng,et al.Research PaperEffects of pyraclostrobin on growth, oxidative stress, and gene expression in relation to stress and ATP-binding cassette transporters in Tetrahymenathermophila[J].Journal of Oceanology and Limnology,2024,42(01):150-162. DOI： 10.1007/s00343-023-2378-0.

摘要

Abstract

Pyraclostrobin (PYR)

a widely used fungicide

has negative effects on fish and algae

but its toxicity in protozoa remains unclear. In this study

the effects of PYR on the growth

oxidative stress

and gene expression related to stress and ATP-binding cassette (ABC) transporters in

Tetrahymena

thermophila

were investigated. The result showed that the 96-h IC

of PYR against

thermophila

was 17.2 mg/L. Moreover

PYR inhibited the growth of

thermophila

in concentration- or time-dependent manner. A morphological study revealed that the shape and size of

thermophila

changed

and damage of cell membrane surface was observed by scanning electron microscopy after 96 h of PYR exposure. The activities of superoxide dismutase (SOD) and catalase (CAT) increased throughout the experiment. In contrast

the glutathione (GSH) content was increased at 24 h and 48 h of exposure and decreased at 96 h. Moreover

a significant increase in malondialdehyde (MDA) level was observed in

thermophila

after 96 h of exposure. Furthermore

PYR upregulated the

HSP703

HSP705

GPx2

and

ABAC15

gene expression in the 0.1–5-mg/L groups and downregulated the

HSP704

HSP90

TGR

and

ABCC52

mRNA levels at 96 h of exposure. These results suggest that PYR may exert adverse effects on

thermophila

by inducing oxidative stress and changing the gene expression related to ABC transporters and stress

which may enrich the understanding of the toxicity mechanism of PYR in aquatic organisms and provide reference data for aquatic ecological risk assessments.

关键词

Keywords

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DOI：10.1007/s00343-023-2378-0

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