Structural characterization of sulfated galactofucan from <italic style="font-style: italic">Undaria pinnatifida</italic> and its effect on type 2 diabetic mice

Songze KE; Bo ZHANG; Yanlei YU; Sijia WANG; Weihua JIN; Jian WU; Jianwei CHEN; Huawei ZHANG; Bin WEI; Hong WANG

doi:10.1007/s00343-021-1307-3

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Structural characterization of sulfated galactofucan from Undaria pinnatifida and its effect on type 2 diabetic mice

Biology | Updated：2023-04-27

- Structural characterization of sulfated galactofucan from Undaria pinnatifida and its effect on type 2 diabetic mice
- Structural characterization of sulfated galactofucan from Undaria pinnatifida and its effect on type 2 diabetic mice
- 海洋湖沼学报（英文） 2023年41卷第1期页码：300-313
- Affiliations：
  
  1.College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Moganshan Research Institute at Deqing County Zhejiang University of Technology, Zhejiang University of Technology, Hangzhou 310014, China
  2.Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles CA 90024, USA
  3.College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China
  4.Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province, Hangzhou 310014, China
  5.Zhejiang Provincial Key Laboratory of Traditional Chinese Medicine Pharmaceutical Technology, Hangzhou 310014, China
- Author bio：
  
  Bin WEI, E-mail: binwei@zjut.edu.cn
  Hong WANG, E-mail: hongw@zjut.edu.cn
- Funds：
  
  the National Key Research and Development Program(2018YFC0311003);the National Key Research and Development Program(2017YFE0103100);the National Natural Science Foundation of China(81903534);the National Natural Science Foundation of China(81773628);the National Natural Science Foundation of China(81741165);High Level Talent Special Support Plan of Zhejiang Province(2019R52009);© Chinese Society for Oceanology and Limnology, Science Press and Springer-Verlag GmbH Germany, part of Springer Nature 2023Electronic supplementary material Supplementary material (Supplementary Figs.S1–S2) is available in the online version of this article at https://doi.org/10.1007/s00343-021-1307-3.
- DOI：10.1007/s00343-021-1307-3
  中图分类号：
- 收稿：2021-09-19，
  
  录用：2021-11-1，
  
  网络首发：2021-12-27，
  
  纸质出版：2023-01
- Accepted：
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Structural characterization of sulfated galactofucan from Undaria pinnatifida and its effect on type 2 diabetic mice[J]. 海洋湖沼学报（英文）, 2023,41(1):300-313.

Songze KE, Bo ZHANG, Yanlei YU, et al. Structural characterization of sulfated galactofucan from Undaria pinnatifida and its effect on type 2 diabetic mice[J]. Journal of Oceanology and Limnology, 2023, 41(1): 300-313.
Structural characterization of sulfated galactofucan from Undaria pinnatifida and its effect on type 2 diabetic mice[J]. 海洋湖沼学报（英文）, 2023,41(1):300-313. DOI： 10.1007/s00343-021-1307-3.

Songze KE, Bo ZHANG, Yanlei YU, et al. Structural characterization of sulfated galactofucan from Undaria pinnatifida and its effect on type 2 diabetic mice[J]. Journal of Oceanology and Limnology, 2023, 41(1): 300-313. DOI： 10.1007/s00343-021-1307-3.

摘要

Abstract

A sulfated galactofucan designated as UpG was obtained from the brown algae

Undaria pinnatifida

by calcium chloride extraction. Chemical analyses showed that UpG is composed of galactose and fucose at a high sulfation level. Low-molecular weight UpGP-0.5 was prepared from UpG through acid hydrolysis for structure characterization. The backbones of UpG are determined to be α-(1

3)-Fuc

α-(1

4)-Gal

α-(1

3)-Gal

and α-(1

6)-Gal by GC-MS

FT-IR

NMR

and LC-MS analyses. Sulfate groups are modified at C2 and/or C4 of fucose and C3 and/or C4 of galactose. UpG could partially lower blood sugar and serum lipid levels in type 2 diabetic mice. Moreover

UpG treatment regulates the abundance of some specific gut microbiota

such as enriching the abundance of

Muribaculum

and Christensenellaceae

and reducing that of

Bilophila

Tannerellaceae

Candidatus Saccharimonas

and

Anaerotruncus

. The findings characterized the detailed structure of a sulfated galactofucan and investigated its potential for the treatment of type 2 diabetes mellitus.

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Keywords

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Structural characterization of sulfated galactofucan from Undaria pinnatifida and its effect on type 2 diabetic mice

Structural characterization of sulfated galactofucan from Undaria pinnatifida and its effect on type 2 diabetic mice

DOI：10.1007/s00343-021-1307-3

摘要

Abstract

关键词

Keywords

references