Magnetotactic bacteria from the human gut microbiome associated with orientation and navigation regions of the brain

Rozalyn A. SIMON; Purnika Damindi RANASINGHE; Nawroz BARAZANJI; Malin Bergman JUNGESTRÖM; Jie XU; Olga BEDNARSKA; Lena SERRANDER; Maria ENGSTRÖM; Dennis A. BAZYLINSKI; Åsa V. KEITA; Susanna WALTER

doi:10.1007/s00343-021-0495-1

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Magnetotactic bacteria from the human gut microbiome associated with orientation and navigation regions of the brain

Special Section: Magnetotactic Bacteria and Magnetoreception | Updated：2023-05-20

- Magnetotactic bacteria from the human gut microbiome associated with orientation and navigation regions of the brain
- Magnetotactic bacteria from the human gut microbiome associated with orientation and navigation regions of the brain
- 海洋湖沼学报（英文） 2021年39卷第6期页码：2044-2052
- Affiliations：
  
  1.Center for Medical Image Science and Visualization(CMIV), Linköping University, Linköping 58183, Sweden
  2.Department of Health, Medicine, and Caring Sciences, Linko?ping University, Linko?ping 58183, Sweden
  3.Division of Infection and Inflammation, Department of Biomedical and Clinical Sciences, Linköping University, Linköping 58183, Sweden
  4.Institute of Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast BT95 DL, United Kingdom
  5.School of Life Sciences, University of Nevada at Las Vegas, Las Vegas, Nevada 89154, USA
  6.Division of Surgery, Orthopedics and Oncology, Department of Clinical and Experimental Medicine, Linköping University, Linköping 58183, Sweden
- Author bio：
  
  Rozalyn A. SIMON, rozalyn.simon@liu.se
- Funds：
  
  the AFA Insurance Research Foundation;the County Council of Östergötland, a Bengt Ihre Research Fellowship;the Ruth and Richard Julin Foundation;the US National Science Foundation(EAR-1423939);© Chinese Society for Oceanology and Limnology, Science Press and Springer-Verlag GmbH Germany, part of Springer Nature 2021Electronic supplementary material Supplementary material (Supplementary Table S1) is available in the online version of this article at https://doi.org/10.1007/s00343-021-0495-1.
- DOI：10.1007/s00343-021-0495-1
  中图分类号：
- 收稿：2020-12-31，
  
  录用：2021-2-23，
  
  网络首发：2021-04-08，
  
  纸质出版：2021-11
- Accepted：
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Magnetotactic bacteria from the human gut microbiome associated with orientation and navigation regions of the brain[J]. 海洋湖沼学报（英文）, 2021,39(6):2044-2052.

Rozalyn A. SIMON, Purnika Damindi RANASINGHE, Nawroz BARAZANJI, et al. Magnetotactic bacteria from the human gut microbiome associated with orientation and navigation regions of the brain[J]. Journal of Oceanology and Limnology, 2021, 39(6): 2044-2052.
Magnetotactic bacteria from the human gut microbiome associated with orientation and navigation regions of the brain[J]. 海洋湖沼学报（英文）, 2021,39(6):2044-2052. DOI： 10.1007/s00343-021-0495-1.

Rozalyn A. SIMON, Purnika Damindi RANASINGHE, Nawroz BARAZANJI, et al. Magnetotactic bacteria from the human gut microbiome associated with orientation and navigation regions of the brain[J]. Journal of Oceanology and Limnology, 2021, 39(6): 2044-2052. DOI： 10.1007/s00343-021-0495-1.

摘要

Abstract

Magnetotactic bacteria (MTB)

ubiquitous in soil and fresh and saltwater sources have been identified in the microbiome of humans and many animals. MTB endogenously produce magnetic nanocrystals enabling them to orient and navigate along geomagnetic fields. Similar magnetite deposits have been found throughout the tissues of the human brain

including brain regions associated with orientation such as the cerebellum and hippocampus

the origins of which remain unknown. Speculation over the role and source of MTB in humans

as well as any association with the brain

remain unanswered. We performed a metagenomic analysis of the gut microbiome of 34 healthy females as well as grey matter volume analysis in magnetite-rich brain regions associated with orientation and navigation with the goal of identifying specific MTB that could be associated with brain structure in orientation and navigation regions. We identified seven MTB in the human gut microbiome:

Magnetococcus marinus

Magnetospira

sp. QH-2

Magnetospirillum

magneticum

Magnetospirillum

sp. ME-1

Magnetospirillum

sp. XM-1

Magnetospirillum gryphiswaldense

and

Desulfovibrio magneticus

. Our preliminary results show significant negative associations between multiple MTB with bilateral flocculonodular lobes of the cerebellum and hippocampus (adjusted for total intracranial volume

uncorrected

0.05). These findings indicate that MTB in the gut are associated with grey matter volume in magnetite-rich brain regions related to orientation and navigation. These preliminary findings support MTB as a potential biogenic source for brain magnetite in humans. Further studies will be necessary to validate and elucidate the relationship between these bacteria

magnetite concentrations

and brain function.

关键词

Keywords

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