<italic style="font-style: italic">Pyropia haitanensis</italic> polysaccharide extends lifespan by inhibiting protein aggregation in <italic style="font-style: italic">Caenorhabditis elegans</italic>

Zhongshan ZHANG; Xiaomei WANG; Yongliang PAN; Zhanqi WANG; Zhengshun WEN; Feng LIU; Genxiang MAO

doi:10.1007/s00343-020-0088-4

Your Location：

Home >

Browse articles >

Pyropia haitanensis polysaccharide extends lifespan by inhibiting protein aggregation in Caenorhabditis elegans

Biology | Updated：2023-06-06

- Pyropia haitanensis polysaccharide extends lifespan by inhibiting protein aggregation in Caenorhabditis elegans
- Pyropia haitanensis polysaccharide extends lifespan by inhibiting protein aggregation in Caenorhabditis elegans
- 海洋湖沼学报（英文） 2021年39卷第2期页码：705-713
- Affiliations：
  
  1.Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, Huzhou University, Huzhou Central Hospital, Huzhou 313000, China
  2.Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food Science and Pharmaceutics, Zhejiang Ocean University, Zhoushan 316022, China
  3.CAS Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
  4.Zhejiang Provincial Key Lab of Geriatrics, Department of Geriatrics, Zhejiang Hospital, Hangzhou 310013, China
- Author bio：
  
  Zhongshan ZHANG, E-mail: 01959@zjhu.edu.cn
- Funds：
  
  the National Natural Science Foundation of China(31700307);the National Natural Science Foundation of China(41876165);the Science and Technology Project of Huzhou(2017ZD2017);the Key Research Program of Frontier Sciences, Chinese Academy of Sciences(QYZDB-SSW-DQC023);© Chinese Society for Oceanology and Limnology, Science Press and Springer-Verlag GmbH Germany, part of Springer Nature 2021
- DOI：10.1007/s00343-020-0088-4
  中图分类号：
- 收稿：2020-02-14，
  
  录用：2020-4-13，
  
  网络首发：2020-05-03，
  
  纸质出版：2021-03
- Accepted：
Scan QR Code
Pyropia haitanensis polysaccharide extends lifespan by inhibiting protein aggregation in Caenorhabditis elegans[J]. 海洋湖沼学报（英文）, 2021,39(2):705-713.

Zhongshan ZHANG, Xiaomei WANG, Yongliang PAN, et al. Pyropia haitanensis polysaccharide extends lifespan by inhibiting protein aggregation in Caenorhabditis elegans[J]. Journal of Oceanology and Limnology, 2021, 39(2): 705-713.
Pyropia haitanensis polysaccharide extends lifespan by inhibiting protein aggregation in Caenorhabditis elegans[J]. 海洋湖沼学报（英文）, 2021,39(2):705-713. DOI： 10.1007/s00343-020-0088-4.

Zhongshan ZHANG, Xiaomei WANG, Yongliang PAN, et al. Pyropia haitanensis polysaccharide extends lifespan by inhibiting protein aggregation in Caenorhabditis elegans[J]. Journal of Oceanology and Limnology, 2021, 39(2): 705-713. DOI： 10.1007/s00343-020-0088-4.

摘要

Abstract

Pyropia haitanensis

polysaccharide (LP) have been found for having many excellent functions such as anti-aging. Using

Caenorhabditis elegans

models

we evaluated the anti-aging activity of LP by observing the lifespan

reproduction

pharyngeal pumping

stress response

quantitative fluorescence of polyglutamic acid

and nuclear localization of DAF-16 of worms. The results reveal that LP could extend the adult lifespan of wild-type and polyQ nematodes

indicating a connection of its anti-aging benefit with the toxicity-suppressing effect. The number of polyglutamic acid aggregates in high concentration groups decreased by 24.39% (

0.05) to the control. The high-dose group strongly induced DAF-16 nuclear translocation over intermediate and cytosolic localizations compared with the control (

0.001). Therefore

we believe that LP could extend the lifespan and reduce the protein aggregation in

C. elegans

through nuclear DAF-16:: GFP expression.

关键词

Keywords

references

AnandanR,GanesanB,ObulesuT,MathewS,AshaKK,LakshmananPT,ZynudheenAA.2013.Antiagingeffectofdietarychitosansupplementationonglutathione-dependentantioxidantsysteminyoungandagedrats. Cell Stress and Chaperones , 18 (1):121-125,https://doi.org/10.1007/s12192-012-0354-2..

BhatiaS,SharmaK,BeraT.2015.Structuralcharacterizationandpharmaceuticalpropertiesofporphyran. Asian Journal of Pharmaceutics , 9 (2):93-101,https://doi.org/10.4103/0973-8398.154698..

BrignullHR,MooreFE,TangSJ,MorimotoRI.2006.Polyglutamineproteinsatthepathogenicthresholddisplayneuron-specificaggregationinapan-neuronal Caenorhabditis elegans model. Journal of Neuroscience , 26 (29):7597-7606,https://doi.org/10.1523/JNEUROSCI.0990-06.2006..

BurkewitzK,ChoeK,StrangeK.2011.Hypertonicstressinducesrapidandwidespreadproteindamagein C. elegans . American Journal of Physiology-Cell Physiology , 301 (3):C566-C576,https://doi.org/10.1152/ajpcell.00030.2011..

CohenE,DillinA.2008.Theinsulinparadox:aging,proteotoxicityandneurodegeneration. Nature Reviews Neuroscience , 9 (10):759-767,https://doi.org/10.1038/nrn2474..

CypserJR,TedescoP,JohnsonTE.2006.Hormesisandagingin Caenorhabditis elegans . Experimental Gerontology , 41 (10):935-939,https://doi.org/10.1016/j.exger.2006.09.004..

FanHC,HoLI,ChiCS,ChenSJ,PengGS,ChanTM,LinSZ,HarnHJ.2014.Polyglutamine(PolyQ)diseases:geneticstotreatments. Cell Transplantation , 23 (4-5):441-458,https://doi.org/10.3727/096368914X678454..

GanL.2007.Therapeuticpotentialofsirtuin-activatingcompoundsinAlzheimer'sdisease. Drug News & Perspectives , 20 (4):233,https://doi.org/10.1358/dnp.2007.20.4.1101162..

GarciaSM,CasanuevaMO,SilvaMV,AmaralMD,MorimotoRI.2007.Neuronalsignalingmodulatesproteinhomeostasisin Caenorhabditis elegans post-synapticmusclecells. Genes & Development , 21 (22):3006-3016,https://doi.org/10.1101/gad.1575307..

GongGP,ZhaoJX,WangCJ,WeiM,DangTT,DengYN,SunJ,SongS,HuangLJ,WangZF.2018.Structuralcharacterizationandantioxidantactivitiesofthedegradationproductsfrom Porphyra haitanensis polysaccharides. Process Biochemistry , 74 :185-193,https://doi.org/10.1016/j.procbio.2018.05.022..

GusellaJF,MacDonaldME.2006.Huntington'sdisease:seeingthepathogenicprocessthroughageneticlens. Trends in Biochemical Sciences , 31 (9):533-540,https://doi.org/10.1016/j.tibs.2006.06.009..

HsuAL,MurphyCT,KenyonC.2003.Regulationofagingandage-relateddiseasebyDAF-16andheat-shockfactor. Science , 300 (5622):1142-1145,https://doi.org/10.1126/science.1083701..

HuangfuJF,LiuJ,SunZ,WangMF,JiangY,ChenZY,ChenF.2013.Antiagingeffectsofastaxanthin-richalga Haematococcus pluvialis onfruitfliesunderoxidativestress. Journal of Agricultural and Food Chemistry , 61 (32):7800-7804,https://doi.org/10.1021/jf402224w..

JeonH,ChaDS.2016.Anti-agingpropertiesof Ribes fasciculatum in Caenorhabditis elegans . Chinese Journal of Natural Medicines , 14 (5):335-342,https://doi.org/10.3724/SP.J.1009.2016.00335..

JinL,SongQR,ZhangWL,GengB,CaiJ.2019.RolesoflongnoncodingRNAsinagingandagingcomplications. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease , 1865 (7):1763-1771,https://doi.org/10.1016/j.bbadis.2018.09.021..

KandasamyS,KhanW,EvansFD,CritchleyAT,ZhangJZ,FittonJH,StringerDN,GardinerVA,PrithivirajB.2014.Afucosecontainingpolymer-richfractionfromthebrownalga Ascophyllum nodosum mediateslifespanincreaseandthermal-tolerancein Caenorhabditis elegans ,bydifferentialeffectsongeneandproteinexpression. Food & Function , 5 (2):275-284,https://doi.org/10.1039/C3FO60050E..

KimDK,ChoKW,AhnWJ,Perez-AcuñaD,JeongH,LeeHJ,LeeSJ.2017.Cell-to-celltransmissionofpolyglutamineaggregatesin C. elegans . Experimental Neurobiology , 26 (6):321-328,https://doi.org/10.5607/en.2017.26.6.321..

KimDK,JeonH,ChaDS.2014.4-Hydroxybenzoicacid-mediatedlifespanextensionin Caenorhabditis elegans . Journal of Functional Foods , 7 :630-640,https://doi.org/10.1016/j.jff.2013.12.022..

LargeEE,PadmanabhanR,WatkinsKL,CampbellRF,XuW,McGrathPT.2017.Modelingofanegativefeedbackmechanismexplainsantagonisticpleiotropyinreproductionindomesticated Caenorhabditis elegans strains. PLoS Genetics , 13 (5):e1006769,https://doi.org/10.1371/journal.pgen.1006769..

LevyM,PoratY,BacharachE,ShalevDE,GazitE.2008.Phenolsulfonphthalein,butnotphenolphthalein,inhibitsamyloidfibrilformation:implicationsforthemodulationofamyloidself-assembly. Biochemistry , 47 (22):5896-5904,https://doi.org/10.1021/bi800043d..

LiangZH,YinDZ.2010.PreventivetreatmentoftraditionalChinesemedicineasantistressandantiagingstrategy. Rejuvenation Research , 13 (2-3):248-252,https://doi.org/10.1089/rej.2009.0867..

LinK,HsinH,LibinaN,KenyonC.2001.Regulationofthe Caenorhabditis elegans longevityproteinDAF-16byinsulin/IGF-1andgermlinesignaling. Nature Genetics , 28 (2):139-145,https://doi.org/10.1038/88850..

LiuQM,XuSS,LiL,PanTM,ShiCL,LiuH,CaoMJ,SuWJ,LiuGM.2017. In vitro and in vivo immunomodulatoryactivityofsulfatedpolysaccharidefrom Porphyra haitanensis . Carbohydrate Polymers , 165 :189-196,https://doi.org/10.1016/jxarbpol.2017.02.032..

LiuYJ,GengLH,ZhangJJ,WangJ,ZhangQ,DuanDL,ZhangQB.2018.Oligo-porphyranamelioratesneurobehavioraldeficitsinParkinsonianmicebyregulatingthePI3K/Akt/Bcl-2pathway. Marine Drugs , 16 (3):82,https://doi.org/10.3390/md16030082..

MasoroEJ.2005.Overviewofcaloricrestrictionandageing. Mechanisms of Ageing and Development , 126 (9):913-922,https://doi.org/10.1016/j.mad.2005.03.012..

MazzeoLEM,DershD,BoccittoM,KalbRG,LamitinaT.2012.StressandaginginducedistinctpolyQproteinaggregationstates. Proceedings of the National Academy of Sciences of the United States of America , 109 (26):10587-10592,https://doi.org/10.1073/pnas.1108766109..

MonickarajF,AravindS,NandhiniP,PrabuP,SathishkumarC,MohanV,BalasubramanyamM.2013.Acceleratedfatcellaginglinksoxidativestressandinsulinresistanceinadipocytes. Journal of Biosciences , 38 (1):113-122,https://doi.org/10.1007/s12038-012-9289-0..

MorleyJF,BrignullHR,WeyersJJ,MorimotoRI.2002.Thethresholdforpolyglutamine-expansionproteinaggregationandcellulartoxicityisdynamicandinfluencedbyagingin Caenorhabditis elegans . Proceedings of the National Academy of Sciences of the United States of America , 99 (16):10417-10422,https://doi.org/10.1073/pnas.152161099..

PandeyS,TiwariS,KumarA,NiranjanA,ChandJ,LehriA,ChauhanPS.2018.Antioxidantandanti-agingpotentialofJuniperberry( Juniperus communis L.)essentialoilin Caenorhabditis elegans modelsystem. Industrial Crops and Products , 120 :113-122,https://doi.org/10.1016/j.indcrop.2018.04.066..

PetrascheckM,YeXL,BuckLB.2007.Anantidepressantthatextendslifespaninadult Caenorhabditis elegans . Nature , 450 (7169):553-556,https://doi.org/10.1038/nature05991..

PowersET,MorimotoRI,DillinA,KellyJW,BalchWE.2009.Biologicalandchemicalapproachestodiseasesofproteostasisdeficiency. Annual Review of Biochemistry , 78 :959-991,https://doi.org/10.1146/annurev.biochem.052308.114844..

PowolnyAA,SinghSV,MelovS,HubbardA,FisherAL.2011.Thegarlicconstituentdiallyltrisulfideincreasesthelifespanof C. elegans viaskn-1activation. Experimental Gerontology , 46 (6):441-452,https://doi.org/10.1016/j.exger.2011.01.005..

SunCJ,WuF,ChenDD,GeJB.2018.Therapeuticeffectsofpolysaccharidesextractedfrom Porphyra yezoensis inratswithcerebralischemia/reperfusioninjury. Archives of Biological Sciences , 70 (2):233-239,https://doi.org/10.2298/ABS170621039S..

SutherlandJE,LindstromSC,NelsonWA,BrodieJ,LynchMDJ,HwangMS,ChoiHG,MiyataM,KikuchiN,OliveiraMC,FarrT,NeefusC,Mols-MortensenA,MilsteinD,MüllerKM.2011.Anewlookatanancientorder:genericrevisionofthebangiales(Rhodophyta). Journal of Phycology , 47 (5):1131-1151,https://doi.org/10.1111/j.1529-8817.2011.01052.x..

WangH,DuennwaldML,RobertsBE,RozeboomLM,ZhangYL,SteeleAD,KrishnanR,SuLJ,GriffinD,MukhopadhyayS,HennessyEJ,WeigeleP,BlanchardBJ,KingJ,DenizAA,BuchwaldSL,IngramVM,LindquistS,ShorterJ.2008.Directandselectiveeliminationofspecificprionsandamyloidsby4,5-dianilinophthalimideandanalogs. Proceedings of the National Academy of Sciences of the United States of America , 105 (20):7159-7164,https://doi.org/10.1073/pnas.0801934105..

WaterstonRH,BrennerS.1978.Asuppressormutationinthenematodeactingonspecificallelesofmanygenes. Nature , 275 (5682):715-719,https://doi.org/10.1038/275715a0..

WuMY,KangX,WangQ,ZhouCY,MohanC,PengA.2017.RegulatorofGproteinsignaling-1modulatesparaquat-inducedoxidativestressandlongevityviatheinsulinlikesignalingpathwayin Caenorhabditis elegans . Toxicology Letters , 273 :97-105,https://doi.org/10.1016/j.toxlet.2017.03.027..

XuJ,JiangYJ,WanL,WangQ,HuangZB,LiuYM,WuYL,ChenZY,LiuX.2017.Feedingrecombinant E. coli withGST-mBmKTXfusionproteinincreasesthefecundityandlifespanof Caenorhabditis elegans . Peptides , 89 :1-8,https://doi.org/10.1016/j.peptides.2017.01.003..

ZhangHR,PanN,XiongSQ,ZouSL,LiHF,XiaoLY,CaoZJ,TunnacliffeA,HuangZB.2012.Inhibitionofpolyglutamine-mediatedproteotoxicityby Astragalus membranaceus polysaccharidethroughtheDAF-16/FOXOtranscriptionfactorin Caenorhabditis elegans . Biochemical Journal , 441 (1):417-424,https://doi.org/10.1042/BJ20110621..

ZhangZS,WangXM,LvF,XieXC,ZhangSY,CaiCE,JiaR,PanYL,LiuF.2020.Anti-complementaryactivityofadegradedsulfatedheterogalactanfromredalga Pyropia haitanensis . International Journal of Biological Macromolecules , 147 :527-533,https://doi.org/10.1016/j.ijbiomac.2020.01.045..

ZhaoP,NiuJF,HuanL,GuWH,WuMJ,WangGC.2019.Agarextractionfrom Pyropia haitanensis residueaftertheremovalandpurificationofphycobiliproteins. Journal of Applied Phycology , 31 (4):2497-2505,https://doi.org/10.1007/s10811-019-1735-z..

ZhaoSX,ChengQ,PengQ,YuXS,YinXQ,LiangM,MaCW,HuangZB,JiaWZ.2018.Antioxidantpeptidesderivedfromthehydrolyzateofpurpleseaurchin( Strongylocentrotus nudus )gonadalleviateoxidativestressin Caenorhabditis elegans . Journal of Functional Foods , 48 :594-604,https://doi.org/10.1016/jjff.2018.07.060..

ZhaoTT,ZhangQB,QiHM,ZhangH,NiuXZ,XuZH,LiZE.2006.Degradationofporphyranfrom Porphyra haitanensis andtheantioxidantactivitiesofthedegradedporphyranswithdifferentmolecularweight. International Journal of Biological Macromolecules , 38 (1):45-50,https://doi.org/10.1016/j.ijbiomac.2005.12.018..

ZhouL,WangL,BaiSJ,XingS,LiWN,MaJF,FuXQ.2018.KnockdownofLMW-PTPenhancesstressresistancein Caenorhabditis elegans . International Journal of Biological Macromolecules , 113 :1015-1023,https://doi.org/10.1016/j.ijbiomac.2018.03.014..

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Effects of Poria cocos polysaccharide on growth performance, physiological parameters, and lipid metabolism of spotted sea bass Lateolabrax maculatus

Isolation of a novel strain of Cyanobacterium sp. with good adaptation to extreme alkalinity and high polysaccharide yield

Vertical variations of dissolved carbohydrates in the North Yap Trench

Roles of polysaccharide from Branchiostoma belcheri in anti-DNA oxidation and anti-tumor activity in S180 mice

基于LMI极点配置的高空台飞行环境模拟系统PI增益调度控制研究

Pyropia haitanensis polysaccharide extends lifespan by inhibiting protein aggregation in Caenorhabditis elegans

Pyropia haitanensis polysaccharide extends lifespan by inhibiting protein aggregation in Caenorhabditis elegans

DOI：10.1007/s00343-020-0088-4

摘要

Abstract

关键词

Keywords

references