A new acyclic peroxide from <italic style="font-style: italic">Aspergillus nidulans</italic> SD-531, a fungus obtained from deep-sea sediment of cold spring in the South China Sea

Fengyi LÜ; Xiaoming LI; Luping CHI; Linghong MENG; Bingui WANG

doi:10.1007/s00343-020-0052-3

Your Location：

Home >

Browse articles >

A new acyclic peroxide from Aspergillus nidulans SD-531, a fungus obtained from deep-sea sediment of cold spring in the South China Sea

Chemistry | Updated：2023-04-27

- A new acyclic peroxide from Aspergillus nidulans SD-531, a fungus obtained from deep-sea sediment of cold spring in the South China Sea
- A new acyclic peroxide from Aspergillus nidulans SD-531, a fungus obtained from deep-sea sediment of cold spring in the South China Sea
- 海洋湖沼学报（英文） 2020年38卷第4期页码：1225-1232
- Affiliations：
  
  1.Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, and Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China
  2.College of Earth Science, University of Chinese Academy of Sciences, Beijing 100049, China
  3.Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China
- Author bio：
  
  WANG Bingui, wangbg@qdio.ac.cn
- Funds：
  
  the National Key R & D Program of China(2018YFC0310800);© Chinese Society for Oceanology and Limnology, Science Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020
- DOI：10.1007/s00343-020-0052-3
  中图分类号：
- 收稿：2020-01-19，
  
  录用：2020-3-3，
  
  网络首发：2020-04-16，
  
  纸质出版：2020-07
- Accepted：
Scan QR Code
A new acyclic peroxide from Aspergillus nidulans SD-531, a fungus obtained from deep-sea sediment of cold spring in the South China Sea[J]. 海洋湖沼学报（英文）, 2020,38(4):1225-1232.

Fengyi LÜ, Xiaoming LI, Luping CHI, et al. A new acyclic peroxide from Aspergillus nidulans SD-531, a fungus obtained from deep-sea sediment of cold spring in the South China Sea[J]. Journal of Oceanology and Limnology, 2020, 38(4): 1225-1232.
A new acyclic peroxide from Aspergillus nidulans SD-531, a fungus obtained from deep-sea sediment of cold spring in the South China Sea[J]. 海洋湖沼学报（英文）, 2020,38(4):1225-1232. DOI： 10.1007/s00343-020-0052-3.

Fengyi LÜ, Xiaoming LI, Luping CHI, et al. A new acyclic peroxide from Aspergillus nidulans SD-531, a fungus obtained from deep-sea sediment of cold spring in the South China Sea[J]. Journal of Oceanology and Limnology, 2020, 38(4): 1225-1232. DOI： 10.1007/s00343-020-0052-3.

摘要

Abstract

A new acyclic peroxide derivative asperoxide A (

)

along with 13 known compounds

namely

microperfuranone (

)

9-hydroxymicroperfuranone (

)

gibellulin A (

)

lecanoric acid (

)

terrequinone A (

)

sterigmatocystin (

)

isosecosterigmatocystin (

)

arugosin C (

)

curvularin (

)

3'-diindolylmethane (

)

austinol (

)

austin (

)

and dehydroaustin (

)

were isolated and identified from the culture extract of

Aspergillus nidulans

SD-531

a fungus obtained from the deep-sea sediment of cold spring in the South China Sea. Their structures were determined based on detailed interpretation of nuclear magnetic resonance (NMR) spectroscopic and mass spectrometry data analysis. All the isolated compounds were evaluated for antimicrobial activities against human and aquatic bacteria as well as plant pathogenic fungi. Compounds

and

exhibited antimicrobial activities against some of the tested strains with minimum inhibitory concentration (MIC) values ranging from 2 to 64 ǌg/mL. Compounds

and

displayed strongest activities among the tested samples and might be used as promising molecules for the development of natural antimicrobial agents.

关键词

Keywords

references

N Bunbamrung , C Intaraudom , S Supothina , S Komwijit , P Pittayakhajonwut . Antibacterial and antiphytopathogenic substances from the insect pathogenic fungus Gibellula sp . BCC36964. Phytochemistry Letters , 2015 . 12 142 - 147 . DOI: 10.1016/j.phytol.2015.03.011 http://doi.org/10.1016/j.phytol.2015.03.011 .

V M Dembitsky , T A Gloriozova , V V Poroikov . Natural peroxy anticancer agents . Mini-Reviews in Medicinal Chemistry , 2007 . 7 ( 6 ): 571 - 589 . DOI: 10.2174/138955707780859396 http://doi.org/10.2174/138955707780859396 .

V M Dembitsky . Bioactive peroxides as potential therapeutic agents . European Journal of Medicinal Chemistry , 2008 . 43 ( 2 ): 223 - 251 . DOI: 10.1016/j.ejmech.2007.04.019 http://doi.org/10.1016/j.ejmech.2007.04.019 .

Z S Deng , A P Deng , D Luo , D C Gong , K Zou , Y Peng , Z Y Guo . Biotransformation of (-)-(10E, 15S)-10, 11-dehydrocurvularin . Natural Product Communications , 2015 . 10 ( 7 ): 1277 - 1278 . DOI: 10.1177/1934578X1501000735 http://doi.org/10.1177/1934578X1501000735 .

H Fujimoto , T Asai , Y P Kim , M Ishibashi . Nine constituents including six xanthone-related compounds isolated from two ascomycetes, Gelasinospora santi-florii and Emericella quadrilineata, found in a screening study focused on immunomodulatory activity . Chemical & Pharmaceutical Bulletin , 2006 . 54 ( 4 ): 550 - 553 . DOI: 10.1248/cpb.54.550 http://doi.org/10.1248/cpb.54.550 .

H Gandhi , K OoReilly , M K Gupta , C Horgan , E M OoLeary , T P O'Sullivan . Advances in the synthesis of acyclic peroxides . RSC Advances , 2017 . 7 ( 32 ): 19506 - 19556 . DOI: 10.1039/C6RA28489B http://doi.org/10.1039/C6RA28489B .

U W Hawas , A A El-Beih , A M El-Halawany . Bioactive anthraquinones from endophytic fungus Aspergillus versicolor isolated from red sea algae . Archives of Pharmacal Research , 2012 . 35 ( 10 ): 1749 - 1756 . DOI: 10.1007/s12272-012-1006-x http://doi.org/10.1007/s12272-012-1006-x .

H Hayashi , M Mukaihara , S Murao , M Arai , A Y Lee , J Clardy . Acetoxydehydroaustin, a new bioactive compound, and related compound neoaustin from Penicillium sp . MG-11. Bioscience, Biotechnology, and Biochemistry , 1994 . 58 ( 2 ): 334 - 338 . DOI: 10.1271/bbb.58.334 http://doi.org/10.1271/bbb.58.334 .

J He , E M K Wijeratne , B P Bashyal , J X Zhan , C J Seliga , M X Liu , E E Pierson , L S Pierson , H D Vanetten , A A L Gunatilaka . Cytotoxic and other metabolites of Aspergillus inhabiting the rhizosphere of sonoran desert plants . Journal of Natural Products , 2004 . 67 ( 12 ): 1985 - 1991 . DOI: 10.1021/np040139d http://doi.org/10.1021/np040139d .

M D Higgs , D J Faulkner . Plakortin, an antibiotic from Plakortis halichondrioides . The Journal of Organic Chemistry , 1978 . 43 ( 18 ): 3454 - 3457 . DOI: 10.1021/jo00412a006 http://doi.org/10.1021/jo00412a006 .

S R M Ibrahim , R Ebel , V Wray , W E G Müller , R Edrada-Ebel , P Proksch . Diacarperoxides, norterpene cyclic peroxides from the spongeDiacarnusmegaspinorhabdosa . Journal of Natural Products , 2008 . 71 ( 8 ): 1358 - 1364 . DOI: 10.1021/np800102u http://doi.org/10.1021/np800102u .

T Narui , K Sawada , S Takatsuki , T Okuyama , C F Culberson , W L Culberson , S Shibata . NMR assignments of depsides and tridepsides of the lichen family Umbilicariaceae . Phytochemistry , 1998 . 48 ( 5 ): 815 - 822 . DOI: 10.1016/s0031-9422(97)00958-8 http://doi.org/10.1016/s0031-9422(97)00958-8 .

S Roy , R Gajbhiye , M Mandal , C Pal , A Meyyapan , J Mukherjee , P Jaisankar . Synthesis and antibacterial evaluation of 3, 3'-diindolylmethane derivatives . Medicinal Chemistry Research , 2013 . 23 ( 2 ): 1371 - 1377 . DOI: 10.1007/s00044-013-0737-7 http://doi.org/10.1007/s00044-013-0737-7 .

C J Wu , C W Li , C B Cui . Seven new and two known lipopeptides as well as five known polyketides: the activated production of silent metabolites in a marinederived fungus by chemical mutagenesis strategy using diethyl sulphate . Marine Drugs , 2014 . 12 ( 4 ): 1815 - 1838 . DOI: 10.3390/md12041815 http://doi.org/10.3390/md12041815 .

S Q Yang , X M Li , G M Xu , X Li , C Y An , B G Wang . Antibacterial anthraquinone derivatives isolated from a mangrove-derived endophytic fungus Aspergillus nidulans by ethanol stress strategy . The Journal of Antibiotics , 2018 . 71 ( 9 ): 778 - 784 . DOI: 10.1038/s41429-018-0063-x http://doi.org/10.1038/s41429-018-0063-x .

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Discovery of prenylated indole alkaloid and natural xanthone from cold-seep sediment derived fungus Talaromyces funiculosus SD-523

Isolation and identification of antimicrobial metabolites from sea anemone-derived fungus Emericella sp. SMA01

Antimicrobial activities of novel cultivable bacteria isolated from marine sponge Tedania anhelans

高压涡轮封严流与主流相互作用的机理研究

增广预测模型的航空发动机多变量约束预测控制

A new acyclic peroxide from Aspergillus nidulans SD-531, a fungus obtained from deep-sea sediment of cold spring in the South China Sea

A new acyclic peroxide from Aspergillus nidulans SD-531, a fungus obtained from deep-sea sediment of cold spring in the South China Sea

DOI：10.1007/s00343-020-0052-3

摘要

Abstract

关键词

Keywords

references