Exploring the sublethal genotoxic effects of class II organophosphorus insecticide quinalphos on freshwater fish <italic style="font-style: italic">Cyprinus carpio</italic>

Devan HEMALATHA; Bojan NATARAJ; Basuvannan RANGASAMY; Kannan MAHARAJAN; Mathan RAMESH

doi:10.1007/s00343-019-9104-y

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Exploring the sublethal genotoxic effects of class II organophosphorus insecticide quinalphos on freshwater fish Cyprinus carpio

Biology | Updated：2023-06-06

- Exploring the sublethal genotoxic effects of class II organophosphorus insecticide quinalphos on freshwater fish Cyprinus carpio
- Exploring the sublethal genotoxic effects of class II organophosphorus insecticide quinalphos on freshwater fish Cyprinus carpio
- 海洋湖沼学报（英文） 2021年39卷第2期页码：661-670
- Affiliations：
  
  1.Unit of Toxicology, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore-641046, Tamil Nadu, India
  2.Department of Zoology, PSG College of Arts & Science, Coimbatore-641014, Tamil Nadu, India
- Author bio：
  
  Mathan RAMESH, E-mail: mathanramesh@yahoo.com
- Funds：
  
  © Chinese Society for Oceanology and Limnology, Science Press and Springer-Verlag GmbH Germany, part of Springer Nature 2021
- DOI：10.1007/s00343-019-9104-y
  中图分类号：
- 收稿：2019-07-05，
  
  录用：2019-9-6，
  
  网络首发：2019-11-21，
  
  纸质出版：2021-03
- Accepted：
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Exploring the sublethal genotoxic effects of class II organophosphorus insecticide quinalphos on freshwater fish Cyprinus carpio[J]. 海洋湖沼学报（英文）, 2021,39(2):661-670.

Devan HEMALATHA, Bojan NATARAJ, Basuvannan RANGASAMY, et al. Exploring the sublethal genotoxic effects of class II organophosphorus insecticide quinalphos on freshwater fish Cyprinus carpio[J]. Journal of Oceanology and Limnology, 2021, 39(2): 661-670.
Exploring the sublethal genotoxic effects of class II organophosphorus insecticide quinalphos on freshwater fish Cyprinus carpio[J]. 海洋湖沼学报（英文）, 2021,39(2):661-670. DOI： 10.1007/s00343-019-9104-y.

Devan HEMALATHA, Bojan NATARAJ, Basuvannan RANGASAMY, et al. Exploring the sublethal genotoxic effects of class II organophosphorus insecticide quinalphos on freshwater fish Cyprinus carpio[J]. Journal of Oceanology and Limnology, 2021, 39(2): 661-670. DOI： 10.1007/s00343-019-9104-y.

摘要

Abstract

The genotoxic effects of quinalphos (QP) were evaluated in the erythrocytes of

Cyprinus carpio

using the comet

micronucleus

and nuclear abnormality assays. The 96 h LC

value of quinalphos

estimated by static renewal system

was 10.9 μL/L. On the basis of the LC

value

two sublethal concentrations (1.09 and 2.18 μL/L) of the compound were used together with cyclophosphamide (5 mg/L) as the positive control. The fish were exposed for 35 d

and sampling was done at the end of 7

and 35 d. Our results reveal a significant dose-dependent increase in the frequencies of DNA strand breaks

micronucleus

and nuclear abnormalities. Similar responses were also observed in fish exposed to the positive genotoxin cyclophosphamide. The collective findings demonstrated that quinalphos exerts a genotoxic effect on

C. carpio

. The results further confirmed that the comet

micronucleus

and nuclear abnormality assays are useful tools in determining the potential genotoxicity of pesticides towards aquatic organisms.

关键词

Keywords

references

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Exploring the sublethal genotoxic effects of class II organophosphorus insecticide quinalphos on freshwater fish Cyprinus carpio

Exploring the sublethal genotoxic effects of class II organophosphorus insecticide quinalphos on freshwater fish Cyprinus carpio

DOI：10.1007/s00343-019-9104-y

摘要

Abstract

关键词

Keywords

references